Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A catcher tank assembly is provided for a waterjet cutting machine. The catcher tank assembly includes a catcher tank having a plurality of tank sections detachably coupleable together in a side-by-side manner to collectively define a catcher tank having a desired configuration. The catcher tank assembly further includes a workpiece support system detachably coupleable to an interior cavity of the catcher tank. The workpiece support system may include a plurality of workpiece support modules arrangeable in an array to support a workpiece platform of the waterjet cutting machine. The workpiece platform may be formed, for example, by a series of slats supported transversely to parallel rows of the workpiece support modules. Methods and systems which relate to or include the aforementioned catcher tank assembly are also provided.

Abstract: A catcher tank assembly is provided for a waterjet cutting machine. The catcher tank assembly includes a catcher tank having a plurality of tank sections detachably coupleable together in a side-by-side manner to collectively define a catcher tank having a desired configuration. The catcher tank assembly further includes a workpiece support system detachably coupleable to an interior cavity of the catcher tank. The workpiece support system may include a plurality of workpiece support modules arrangeable in an array to support a workpiece platform of the waterjet cutting machine. The workpiece platform may be formed, for example, by a series of slats supported transversely to parallel rows of the workpiece support modules. Methods and systems which relate to or include the aforementioned catcher tank assembly are also provided.

Abstract: An apparatus for generating and manipulating a high-pressure fluid jet includes an assembly coupled to a motion assembly that imparts motion to the assembly along one or more axes. The motion assembly includes two motors coupled together to form a gimbal wrist, each motor having an axis of rotation. The two axes of rotation of the two motors can be perpendicular to each other, but are not necessarily aligned with the manipulator's axes of motion. The high-pressure fluid assembly incorporates a swivel that can rotate about two axes which may be parallel to the two motors' axes of rotation, allowing the high-pressure tubing contained therein to follow the motion imparted by the gimbal wrist of the motion assembly.

Abstract: A collision detection sensor for a waterjet system provides a signal in the event the device approaches to within a selected distance of an obstruction in the plane of the working surface. An annular pressure switch lying in a first plane provides the signal when radial pressure is applied to a perimeter of the pressure switch via an annular trigger skirt, the trigger skirt applying the radial pressure in response to a collision of the device with an obstacle.

Abstract: A contour follower includes a plurality of sensors spaced around a waterjet nozzle, each of the sensors being configured to measure a distance between a working surface and a first plane, perpendicular to a longitudinal axis of the nozzle. The sensors may include hall-effect sensors lying in the first plane and magnets lying in a second plane, parallel to the working surface. A detecting circuit processes signals from the sensors to determine an angle of the working surface, relative to the first plane, and a distance between an aperture of the nozzle and the working surface. A collision detection sensor provides a signal in the event the device approaches to within a selected distance of an obstruction in the plane of the working surface. A shield plate blocks and dampens secondary spray-back of cutting fluid occurring at low angles above the working surface.

Abstract: An apparatus for generating and manipulating a high-pressure fluid jet includes an end effector assembly coupled to a manipulator that imparts motion to the end effector. The end effector assembly includes a cutting head coupled to a source of high-pressure fluid and to a source of abrasive. A motion assembly is coupled to the cutting head via a clamp positioned around the cutting head. A nozzle body assembly is removably coupled to the cutting head assembly, which may be separated from the cutting head assembly to allow access to the orifice, without removing the cutting head assembly from the clamp. The clamp has a quick release mechanism and an alignment member. The motion assembly includes two motors coupled together to form a gimbal wrist, each motor having a horizontal axis of rotation. The two axes of rotation are perpendicular to each other, but are not necessarily aligned with the manipulator's axes of motion.

Abstract: A contour follower includes a plurality of sensors spaced around a waterjet nozzle, each of the sensors being configured to measure a distance between a working surface and a first plane, perpendicular to a longitudinal axis of the nozzle. The sensors may include hall-effect sensors lying in the first plane and magnets lying in a second plane, parallel to the working surface. A detecting circuit processes signals from the sensors to determine an angle of the working surface, relative to the first plane, and a distance between an aperture of the nozzle and the working surface. A collision detection sensor provides a signal in the event the device approaches to within a selected distance of an obstruction in the plane of the working surface. A shield plate blocks and dampens secondary spray-back of cutting fluid occurring at low angles above the working surface.

Abstract: A system used for the prevention of positional plagiocephaly in which an infant receiving member includes an infant supporting surface, a first portion, and a second portion. An inclined member is positioned at least partially under the first portion of the infant receiving surface such that the first portion of the infant receiving surface is inclined.

Abstract: In accordance with certain aspects of the invention, an exemplary claim can define the steps of providing a rotating mount for the initially cast prosthesis in association with a numerically or computer controlled grinding machine. The grinding wheel is rotatably supported so that the wheel can translate vertically and axially relative to the axis of the workpiece, and can pivot in a plane generally parallel to the axis of the workpiece. In one step, the stem of the workpiece is rotated as the grinding wheel is held in position substantially perpendicular to the axis of the stem. The grinding wheel is then retracted and repositioned along the length of the stem through a series of successive positions. At each position, the grinding wheel is rotated in contact with the rotating workpiece. Once the grinding wheel is positioned at the transition region, the workpiece is preferably rotated through 180° on both sides of the transition region.

Abstract: 9 In accordance with certain aspects of the invention, an exemplary claim can define the steps of providing a rotating mount for the initially cast prosthesis in association with a numerically or computer controlled grinding machine. The grinding wheel is rotatably supported so that the wheel can translate vertically and axially relative to the axis of the workpiece, and can pivot in a plane generally parallel to the axis of the workpiece. In one step, the stem of the workpiece is rotated as the grinding wheel is held in position substantially perpendicular to the axis of the stem. The grinding wheel is then retracted and repositioned along the length of the stem through a series of successive positions. At each position, the grinding wheel is rotated in contact with the rotating workpiece. Once the grinding wheel is positioned at the transition region, the workpiece is preferably rotated through 180° on both sides of the transition region.

Abstract: An apparatus for generating and manipulating a high-pressure fluid jet includes an end effector assembly coupled to a manipulator that imparts motion to the end effector along one or more axes. The end effector assembly includes a cutting head coupled to a source of high-pressure fluid and to a source of abrasive, to generate a high-pressure abrasive fluid jet. A motion assembly is coupled to the cutting head via a clamp positioned around the cutting head. A nozzle body assembly is removably coupled to the cutting head assembly upstream of the orifice. The nozzle body assembly may be separated from the cutting head assembly to allow access to the orifice, without removing the cutting head assembly from the clamp. The clamp has a quick release mechanism, allowing an operator to open the clamp by hand to allow access to the cutting head, and an alignment member is provided on an inner surface of the clamp to accurately locate the cutting head in the clamp.

Abstract: A method for treating/preventing positional plagiocephaly in an infant by providing a support surface, positioning the infant on the support surface, positioning the support surface such that the infant's head tilts to a first side when the infant is on the support surface, repositioning the support surface such that the infant's head tilts to a second side opposite the first side when the infant is on the support surface, and repeating these steps such that the infant's head is not longer susceptible to positional plagiocephaly. The invention also relates to an infant garment with an upper portion having an infant torso covering portion and an inclined member engaged with the infant torso covering portion of the infant garment.

Abstract: An infant bed of the present invention includes a frame, a mattress having a first portion and a second portion, and a mattress support that is supported on the frame for supporting the mattress. The mattress support has a first portion that supports the first portion of the mattress. The mattress support also has a second portion that is mechanically tilted about a central longitudinal axis so as to laterally tilt the second portion of the mattress to either side relative to the first portion of the mattress. The infant bed of the present invention is particularly useful for preventing positional plagiocephaly.

Abstract: A method is disclosed for treating/preventing positional plagiocephaly.

Abstract: A method is disclosed for treating/preventing positional plagiocephaly.

Abstract: A gun sight enhancement applied to the sights of a gun to aid in the visual alignment of the sights on a target. Contrasting color dots are applied to the front and rear sights of the gun. The contrasting colors between the front and rear sights enhances the visual aligning of the sights on target. A kit is provided with at least three paint colors; yellow, orange and green. The paint is a tough durable coating that remains resilient to expand and contract with the expansion and contraction of the sights.