Patents by Inventor Robert J. Ono

Robert J. Ono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10138322
    Abstract: Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R? is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: November 27, 2018
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Robert J. Ono, Rudy J. Wojtecki
  • Patent number: 10023697
    Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: July 17, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang
  • Patent number: 9987369
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: June 5, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Victor W. L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
  • Publication number: 20180117162
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).
    Type: Application
    Filed: November 1, 2016
    Publication date: May 3, 2018
    Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Victor W.L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
  • Patent number: 9951179
    Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: April 24, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
  • Patent number: 9854806
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: January 2, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • Patent number: 9809680
    Abstract: Thioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to make the polymers. An amine scavenger is used to remove amine byproducts from the reaction, thus promoting polymer growth to high molecular weight. The polymers have the general structure wherein each R1 is independently an organic or hetero-organic group, a plurality of R2 groups are substituents having molecular weight greater than about 120 Daltons, and n is an integer greater than or equal to 1. The polymers may be functionalized by adding a thiol-reactive group to either end or both ends.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: November 7, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Robert J. Ono, Rudy J. Wojtecki
  • Publication number: 20170303541
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: July 10, 2017
    Publication date: October 26, 2017
    Inventors: Willy Chin, James L. Hedrick, Ashlynn L. Z. Lee, Robert J. Ono, Yi Yan Yang
  • Publication number: 20170158811
    Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
    Type: Application
    Filed: February 20, 2017
    Publication date: June 8, 2017
    Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. NG, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
  • Publication number: 20170137572
    Abstract: Thioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to make the polymers. An amine scavenger is used to remove amine byproducts from the reaction, thus promoting polymer growth to high molecular weight. The polymers have the general structure wherein each R1 is independently an organic or hetero-organic group, a plurality of R2 groups are substituents having molecular weight greater than about 120 Daltons, and n is an integer greater than or equal to 1. The polymers may be functionalized by adding a thiol-reactive group to either end or both ends.
    Type: Application
    Filed: May 17, 2016
    Publication date: May 18, 2017
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Robert J. ONO, Rudy J. WOJTECKI
  • Patent number: 9642360
    Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 9, 2017
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
  • Publication number: 20170121445
    Abstract: Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R? is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 4, 2017
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Robert J. ONO, Rudy J. WOJTECKI
  • Patent number: 9624191
    Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: April 18, 2017
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
  • Publication number: 20170094964
    Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 6, 2017
    Inventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
  • Publication number: 20170073471
    Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: November 25, 2016
    Publication date: March 16, 2017
    Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang
  • Patent number: 9580537
    Abstract: Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R? is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: February 28, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Robert J. Ono, Rudy J. Wojtecki
  • Patent number: 9580554
    Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: February 28, 2017
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
  • Publication number: 20160374335
    Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 29, 2016
    Inventors: Julian M.W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
  • Publication number: 20160338356
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: May 19, 2015
    Publication date: November 24, 2016
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • Publication number: 20160326319
    Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: May 6, 2015
    Publication date: November 10, 2016
    Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang