Patents by Inventor Robert J. Ono
Robert J. Ono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11690380Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: GrantFiled: November 16, 2019Date of Patent: July 4, 2023Assignees: Coral Bay II, LLC, Agency For Science, Technology And ResearchInventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
-
Patent number: 10980234Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: GrantFiled: November 16, 2019Date of Patent: April 20, 2021Assignees: Coral Bay II, LLC, Agency For Science, Technology And ResearchInventors: Willy Chin, James L. Hedrick, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
-
Patent number: 10779539Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: GrantFiled: July 10, 2017Date of Patent: September 22, 2020Assignees: Coral Bay II, LLC., Agency For Science, Technology And ResearchInventors: Willy Chin, James L. Hedrick, Ashlynn L. Z. Lee, Robert J. Ono, Yi Yan Yang, Qingxing Xu
-
Publication number: 20200085059Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: November 16, 2019Publication date: March 19, 2020Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
-
Publication number: 20200077660Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: November 16, 2019Publication date: March 12, 2020Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
-
Patent number: 10138322Abstract: Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R? is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.Type: GrantFiled: November 16, 2016Date of Patent: November 27, 2018Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Robert J. Ono, Rudy J. Wojtecki
-
Patent number: 10023697Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: GrantFiled: November 25, 2016Date of Patent: July 17, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang
-
Patent number: 9987369Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).Type: GrantFiled: November 1, 2016Date of Patent: June 5, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Victor W. L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
-
Publication number: 20180117162Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).Type: ApplicationFiled: November 1, 2016Publication date: May 3, 2018Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Victor W.L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
-
Patent number: 9951179Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: February 20, 2017Date of Patent: April 24, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
-
Patent number: 9854806Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: GrantFiled: May 19, 2015Date of Patent: January 2, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
-
Patent number: 9809680Abstract: Thioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to make the polymers. An amine scavenger is used to remove amine byproducts from the reaction, thus promoting polymer growth to high molecular weight. The polymers have the general structure wherein each R1 is independently an organic or hetero-organic group, a plurality of R2 groups are substituents having molecular weight greater than about 120 Daltons, and n is an integer greater than or equal to 1. The polymers may be functionalized by adding a thiol-reactive group to either end or both ends.Type: GrantFiled: May 17, 2016Date of Patent: November 7, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Robert J. Ono, Rudy J. Wojtecki
-
Publication number: 20170303541Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: July 10, 2017Publication date: October 26, 2017Inventors: Willy Chin, James L. Hedrick, Ashlynn L. Z. Lee, Robert J. Ono, Yi Yan Yang
-
Publication number: 20170158811Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: ApplicationFiled: February 20, 2017Publication date: June 8, 2017Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. NG, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
-
Publication number: 20170137572Abstract: Thioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to make the polymers. An amine scavenger is used to remove amine byproducts from the reaction, thus promoting polymer growth to high molecular weight. The polymers have the general structure wherein each R1 is independently an organic or hetero-organic group, a plurality of R2 groups are substituents having molecular weight greater than about 120 Daltons, and n is an integer greater than or equal to 1. The polymers may be functionalized by adding a thiol-reactive group to either end or both ends.Type: ApplicationFiled: May 17, 2016Publication date: May 18, 2017Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Robert J. ONO, Rudy J. WOJTECKI
-
Patent number: 9642360Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: GrantFiled: June 25, 2015Date of Patent: May 9, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
-
Publication number: 20170121445Abstract: Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R? is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.Type: ApplicationFiled: November 16, 2016Publication date: May 4, 2017Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Robert J. ONO, Rudy J. WOJTECKI
-
Patent number: 9624191Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: September 23, 2015Date of Patent: April 18, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
-
Publication number: 20170094964Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Inventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
-
Publication number: 20170073471Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: November 25, 2016Publication date: March 16, 2017Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Alshakim Nelson, Robert J. Ono, Yi Yan Yang, Mu San Zhang