Abstract: Pulse generating circuitry for an electroporation system is provided. The pulse generating circuitry includes a first voltage source, a second voltage source, and a plurality of electrode addressing circuits. Each electrode addressing circuit is configured to be coupled to an associated electrode and includes a first switch couplable between the electrode and the first voltage source, a second switch couplable between the electrode and the second voltage source, and a third switch couplable between the electrode and a return voltage.