Patents by Inventor Robert J. Siegel

Robert J. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11944538
    Abstract: A method of reducing regurgitation between native leaflets of an atrioventricular heart valve includes advancing a delivery catheter through a sheath, wherein the delivery catheter has a valve leaflet coaptation element mounted over a distal end portion. The coaptation element is positioned within the heart valve and is permitted to radially expand from a compressed configuration to an enlarged configuration for filling a gap between the native leaflets of the heart valve. After deployment, the position of the coaptation element is fixed relative to the heart valve, thereby reducing regurgitation between the native leaflets of the heart valve and improving heart function.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: April 2, 2024
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Stanton J. Rowe, Robert S. Schwartz, Robert A. Van Tassel, Vivian Khalil, Erin M. Spinner, Neil S. Zimmerman, Alexander J. Siegel
  • Patent number: 9763658
    Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: September 19, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
  • Publication number: 20170113068
    Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.
    Type: Application
    Filed: September 28, 2016
    Publication date: April 27, 2017
    Applicants: Cedars-Sinai Medical Center, Board of Regents of the University of Texas System
    Inventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
  • Publication number: 20150231416
    Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Applicants: Board of Regents of the University of Texas System, Cedars-Sinai Medical Center
    Inventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
  • Patent number: 9050448
    Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath adapted to hold media and to permit the immersion of an extremity and comprising one or more ultrasonic transducers to generate and transmit ultrasonic energy to the extremity or the inventive method.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: June 9, 2015
    Assignees: Cedars-Sinai Medical Center, Board of Regents of the University of Texas System
    Inventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
  • Publication number: 20120310331
    Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
    Type: Application
    Filed: April 6, 2012
    Publication date: December 6, 2012
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
  • Publication number: 20120197244
    Abstract: The invention relates to methods for treating, inhibiting, reducing the size of or preventing enlargement of, aneurysms in a subject by delivering thermal or cryo energy to the vasculature of the subject at or near the site of an existing or potential aneurysm.
    Type: Application
    Filed: January 30, 2012
    Publication date: August 2, 2012
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Robert J. Siegel, Michael Shehata
  • Patent number: 8172856
    Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 8, 2012
    Assignee: Cedars-Sinai Medical Center
    Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
  • Publication number: 20100063423
    Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof.
    Type: Application
    Filed: December 19, 2007
    Publication date: March 11, 2010
    Applicants: CEDARS-SINAI MEDICAL CENTER, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
  • Publication number: 20040059351
    Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
    Type: Application
    Filed: July 28, 2003
    Publication date: March 25, 2004
    Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
  • Patent number: 6478765
    Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: November 12, 2002
    Assignee: Transon, LLC
    Inventors: Robert J. Siegel, Robert E. Carter
  • Patent number: 6450975
    Abstract: The ultrasonic angioplasty transmission guide wire has regions of reduced cross-sectional diameter to improve flexibility and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the guide wire. The guide wire has a core of ultrasonic transmission material and an outer jacket surrounding a usable portion of the elongated shaft. The outer jacket is formed of a shrink tubing. At the proximal end are disposed threads configured to connect to a connecting device for an ultrasound transducer. The distal end comprises a smooth ball tip for atraumatic application of ultrasound energy to biological tissue. In one embodiment, the guide wire is formed of stainless steel. In another, the guide wire is formed at least partially of a superelastic metal alloy and in one case is formed at least partially of a shape memory alloy that exhibits superelastic properties when in its martensitic state. In one preferred embodiment, the guide wire is formed of a nickel-titanium alloy.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: September 17, 2002
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lawrence Brennan, Douglas Gesswein, Wayne Cornish, Robert J. Siegel
  • Publication number: 20020007141
    Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.
    Type: Application
    Filed: November 9, 1998
    Publication date: January 17, 2002
    Inventors: ROBERT J. SIEGEL, ROBERT E. CARTER
  • Publication number: 20010039952
    Abstract: Apparatus and method is provided for enhancing the action of anti-cancer agents, which includes the introduction of anti-cancer agent into or proximate a tumor within a body and thereafter introducing ultrasonic energy at the solid tumor with the introduced anti-cancer agent. The ultrasonic energy is sufficient to increase the anti-cancer activity on the solid tumor without significant heating of the solid tumor or surrounding tissue.
    Type: Application
    Filed: November 10, 1998
    Publication date: November 15, 2001
    Applicant: Walter A. Hacker, Ph. D
    Inventors: THOMAS M. PETERSON, ROBERT J. SIEGEL
  • Patent number: 6308714
    Abstract: Apparatus and method is provided for enhancing the action of anti-cancer agents, which includes the introduction of anti-cancer agent into or proximate a tumor within a body and thereafter introducing ultrasonic energy at the solid tumor with the introduced anti-cancer agent. The ultrasonic energy is sufficient to increase the anti-cancer activity on the solid tumor without significant heating of the solid tumor or surrounding tissue.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: October 30, 2001
    Assignee: Coraje, Inc.
    Inventors: Thomas M. Peterson, Robert J. Siegel
  • Patent number: 6113570
    Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: September 5, 2000
    Assignee: Coraje, Inc.
    Inventors: Robert J. Siegel, Robert E. Carter
  • Patent number: 6086573
    Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: July 11, 2000
    Assignee: Transon, LLC
    Inventors: Robert J. Siegel, Robert E. Carter
  • Patent number: 5695460
    Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other vascular obstructions. One embodiment of the present invention utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a vascular system in less time than the time required by activity of the selected dose of thrombolytic agent without the ultrasonic radiation of the thrombosis.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: December 9, 1997
    Assignee: Coraje, Inc.
    Inventors: Robert J. Siegel, Robert E. Carter
  • Patent number: 5660180
    Abstract: An ultrasonic imaging guidewire apparatus for ultrasonic diagnostic imaging of blood vessels, comprising: an elongated, flexible, catheter guide (10) having a plurality of electrical conductors, a transducer seat (11), attached to transducer seat (11) an ultrasonic transducer (14), a flexible distal guidewire (12). Distal guidewire (12) may be ended at its distal end with a protective ball (23). A rotary drive unit (28) for rotation of imaging guidewire together with transducer (14), and an electronic computer (30) for processing signals, obtained by reflecting ultrasonic pulses from tissue of the vessel surrounding transducer (14), into cross-sectional images of vessels.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: August 26, 1997
    Assignee: Coraje, Inc.
    Inventors: Igor Malinowski, Robert J. Siegel
  • Patent number: 5474530
    Abstract: A catheter device incorporating combined ultrasound ablation and balloon dilation components. The catheter device generally comprises an elongate catheter body having proximal and distal ends and an outer surface. Disposed on the outer surface of the catheter body is a dilation balloon. At least one balloon inflation lumen fluidly connects the proximal end of the catheter body to the dilation balloon to permit injection of inflation fluid into the dilation balloon. Extending longitudinally through the catheter body is an ultrasound transmission member having a proximal end and a distal end, with the proximal end being connectable to an ultrasound transducer such that ultrasonic energy will pass through the ultrasound transmission member to the distal end thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: December 12, 1995
    Assignee: Baxter International Inc.
    Inventors: James D. Passafaro, Henry Nita, Robert J. Siegel, Douglas H. Gesswein