Patents by Inventor Robert J. Siegel
Robert J. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9763658Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.Type: GrantFiled: April 6, 2012Date of Patent: September 19, 2017Assignee: CEDARS-SINAI MEDICAL CENTERInventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
-
Publication number: 20170113068Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.Type: ApplicationFiled: September 28, 2016Publication date: April 27, 2017Applicants: Cedars-Sinai Medical Center, Board of Regents of the University of Texas SystemInventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
-
Publication number: 20150231416Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Applicants: Board of Regents of the University of Texas System, Cedars-Sinai Medical CenterInventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
-
Patent number: 9050448Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath adapted to hold media and to permit the immersion of an extremity and comprising one or more ultrasonic transducers to generate and transmit ultrasonic energy to the extremity or the inventive method.Type: GrantFiled: December 19, 2007Date of Patent: June 9, 2015Assignees: Cedars-Sinai Medical Center, Board of Regents of the University of Texas SystemInventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
-
Publication number: 20120310331Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.Type: ApplicationFiled: April 6, 2012Publication date: December 6, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
-
Publication number: 20120197244Abstract: The invention relates to methods for treating, inhibiting, reducing the size of or preventing enlargement of, aneurysms in a subject by delivering thermal or cryo energy to the vasculature of the subject at or near the site of an existing or potential aneurysm.Type: ApplicationFiled: January 30, 2012Publication date: August 2, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Robert J. Siegel, Michael Shehata
-
Patent number: 8172856Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.Type: GrantFiled: July 28, 2003Date of Patent: May 8, 2012Assignee: Cedars-Sinai Medical CenterInventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
-
Publication number: 20100063423Abstract: The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof.Type: ApplicationFiled: December 19, 2007Publication date: March 11, 2010Applicants: CEDARS-SINAI MEDICAL CENTER, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Robert J. Siegel, Yochai Birnbaum, Huai Luo
-
Publication number: 20040059351Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.Type: ApplicationFiled: July 28, 2003Publication date: March 25, 2004Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
-
Patent number: 6478765Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.Type: GrantFiled: November 9, 1998Date of Patent: November 12, 2002Assignee: Transon, LLCInventors: Robert J. Siegel, Robert E. Carter
-
Patent number: 6450975Abstract: The ultrasonic angioplasty transmission guide wire has regions of reduced cross-sectional diameter to improve flexibility and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the guide wire. The guide wire has a core of ultrasonic transmission material and an outer jacket surrounding a usable portion of the elongated shaft. The outer jacket is formed of a shrink tubing. At the proximal end are disposed threads configured to connect to a connecting device for an ultrasound transducer. The distal end comprises a smooth ball tip for atraumatic application of ultrasound energy to biological tissue. In one embodiment, the guide wire is formed of stainless steel. In another, the guide wire is formed at least partially of a superelastic metal alloy and in one case is formed at least partially of a shape memory alloy that exhibits superelastic properties when in its martensitic state. In one preferred embodiment, the guide wire is formed of a nickel-titanium alloy.Type: GrantFiled: December 30, 1999Date of Patent: September 17, 2002Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lawrence Brennan, Douglas Gesswein, Wayne Cornish, Robert J. Siegel
-
Publication number: 20020007141Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.Type: ApplicationFiled: November 9, 1998Publication date: January 17, 2002Inventors: ROBERT J. SIEGEL, ROBERT E. CARTER
-
Publication number: 20010039952Abstract: Apparatus and method is provided for enhancing the action of anti-cancer agents, which includes the introduction of anti-cancer agent into or proximate a tumor within a body and thereafter introducing ultrasonic energy at the solid tumor with the introduced anti-cancer agent. The ultrasonic energy is sufficient to increase the anti-cancer activity on the solid tumor without significant heating of the solid tumor or surrounding tissue.Type: ApplicationFiled: November 10, 1998Publication date: November 15, 2001Applicant: Walter A. Hacker, Ph. DInventors: THOMAS M. PETERSON, ROBERT J. SIEGEL
-
Patent number: 6308714Abstract: Apparatus and method is provided for enhancing the action of anti-cancer agents, which includes the introduction of anti-cancer agent into or proximate a tumor within a body and thereafter introducing ultrasonic energy at the solid tumor with the introduced anti-cancer agent. The ultrasonic energy is sufficient to increase the anti-cancer activity on the solid tumor without significant heating of the solid tumor or surrounding tissue.Type: GrantFiled: November 10, 1998Date of Patent: October 30, 2001Assignee: Coraje, Inc.Inventors: Thomas M. Peterson, Robert J. Siegel
-
Patent number: 6113570Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.Type: GrantFiled: May 13, 1997Date of Patent: September 5, 2000Assignee: Coraje, Inc.Inventors: Robert J. Siegel, Robert E. Carter
-
Patent number: 6086573Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other fistula obstructions. One embodiment of the present invention alternatively utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a fistula.Type: GrantFiled: October 8, 1998Date of Patent: July 11, 2000Assignee: Transon, LLCInventors: Robert J. Siegel, Robert E. Carter
-
Patent number: 5695460Abstract: Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other vascular obstructions. One embodiment of the present invention utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a vascular system in less time than the time required by activity of the selected dose of thrombolytic agent without the ultrasonic radiation of the thrombosis.Type: GrantFiled: May 15, 1995Date of Patent: December 9, 1997Assignee: Coraje, Inc.Inventors: Robert J. Siegel, Robert E. Carter
-
Patent number: 5660180Abstract: An ultrasonic imaging guidewire apparatus for ultrasonic diagnostic imaging of blood vessels, comprising: an elongated, flexible, catheter guide (10) having a plurality of electrical conductors, a transducer seat (11), attached to transducer seat (11) an ultrasonic transducer (14), a flexible distal guidewire (12). Distal guidewire (12) may be ended at its distal end with a protective ball (23). A rotary drive unit (28) for rotation of imaging guidewire together with transducer (14), and an electronic computer (30) for processing signals, obtained by reflecting ultrasonic pulses from tissue of the vessel surrounding transducer (14), into cross-sectional images of vessels.Type: GrantFiled: May 28, 1996Date of Patent: August 26, 1997Assignee: Coraje, Inc.Inventors: Igor Malinowski, Robert J. Siegel
-
Patent number: 5474530Abstract: A catheter device incorporating combined ultrasound ablation and balloon dilation components. The catheter device generally comprises an elongate catheter body having proximal and distal ends and an outer surface. Disposed on the outer surface of the catheter body is a dilation balloon. At least one balloon inflation lumen fluidly connects the proximal end of the catheter body to the dilation balloon to permit injection of inflation fluid into the dilation balloon. Extending longitudinally through the catheter body is an ultrasound transmission member having a proximal end and a distal end, with the proximal end being connectable to an ultrasound transducer such that ultrasonic energy will pass through the ultrasound transmission member to the distal end thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.Type: GrantFiled: June 8, 1994Date of Patent: December 12, 1995Assignee: Baxter International Inc.Inventors: James D. Passafaro, Henry Nita, Robert J. Siegel, Douglas H. Gesswein
-
Patent number: 5324255Abstract: A catheter device incorporating combined ultrasound ablation and balloon dilation components. The catheter device generally comprises an elongate catheter body having proximal and distal ends and an outer surface. Disposed on the outer surface of the catheter body is a dilation balloon. At least one balloon inflation lumen fluidly connects the proximal end of the catheter body to the dilation balloon to permit injection of inflation fluid into the dilation balloon. Extending longitudinally through the catheter body is an ultrasound transmission member having a proximal end and a distal end, with the proximal end being connectable to an ultrasound transducer such that ultrasonic energy will pass through the ultrasound transmission member to the distal end thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.Type: GrantFiled: July 10, 1992Date of Patent: June 28, 1994Assignee: Baxter International Inc.Inventors: James D. Passafaro, Henry Nita, Robert J. Siegel, Douglas H. Gesswein