Patents by Inventor Robert J. Sims

Robert J. Sims has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSION PROTEINS AND METHODS FOR IDENTIFYING BROMODOMAIN INHIBITING COMPOUNDS
    Publication number: 20190048048
    Abstract: The present invention relates methods for identifying bromodomain inhibiting compounds.
    Type: Application
    Filed: June 27, 2018
    Publication date: February 14, 2019
    Applicant: CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Hon-Ren Huang, Robert J. Sims, III, Steven Frank Bellon
  • USE OF CBP/EP300 AND BET INHIBITORS FOR TREATMENT OF CANCER
    Publication number: 20170196878
    Abstract: The present invention relates to the use of CBP/EP300 inhibitors and BET inhibitors for the treatment of cancer. In some embodiments, the use is to treat cancer that is resistant to BET inhibitors.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 13, 2017
    Applicants: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Richard C. Centore, Andrew R. Conery, Karen Gascoigne, Robert J. Sims, III
  • TREATING TH2-MEDIATED DISEASES BY INHIBITION OF BROMODOMAINS
    Publication number: 20160024504
    Abstract: The invention provides methods for treating Th2 cytokine-mediated diseases by inhibiting bromodomain function.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicants: CONSTELLATION PHARMACEUTICALS, INC., GENENTECH, INC.
    Inventors: Brian K. Albrecht, Alexandre Cote, Terry Crawford, Benjamin Fauber, Hon-Ren Huang, Jose M. Lora, Steven Magnuson, Christopher G. Nasveschuk, Andres Salmeron, Robert J. Sims, III, Alexander M. Taylor
  • FUSION PROTEINS AND METHODS FOR IDENTIFYING BROMODOMAIN INHIBITING COMPOUNDS
    Publication number: 20160002306
    Abstract: The present invention relates to fusion proteins comprising at least one chromatin binding module and at least one reporter module, wherein a plurality of fusion proteins are capable of forming foci, and associated methods for identifying bromodomain inhibiting compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 7, 2016
    Applicant: CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Hon-Ren Huang, Robert J. Sims, III, Steven Frank Bellon
  • Methods and apparatus for mitigating rain fading over SATCOM links via information throughput adaptation
    Patent number: 7174179
    Abstract: A remote communications terminal accesses a terrestrial network or information source via a SATCOM link with an earth station hub linked to the network or information source. Information throughput adaptation (ITA) is employed on the SATCOM link to maximize information throughput over the SATCOM link while ensuring acceptable signal quality under varying rain fading conditions. Sufficient power margin is built into the SATCOM link such that, under severe rain fading conditions, the lowest system throughput rate still provides acceptable signal quality. Under lesser rain fading conditions, the data throughput rate is increased via more bandwidth efficient modulation and coding schemes permitted by the higher signal quality which results from greater power margin. The earth station hub and remote terminals monitor the signal quality and communicate to adaptively adjust the modulation and coding used on the forward and return links to maximize information throughput under varying rain fading conditions.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: February 6, 2007
    Assignee: ITT Manufacturing Enterprises, Inc.
    Inventors: Lawrence W. Krebs, Robert J. Sims, Ronald C. Bruno, Christopher Jason Berger, Ronald H. Pawlikowski, Jr.
  • Methods and apparatus for mitigating rain fading over satcom links via information throughput adaptation
    Publication number: 20030054816
    Abstract: A remote communications terminal accesses a terrestrial network or information source via a SATCOM link with an earth station hub linked to the network or information source. Information throughput adaptation (ITA) is employed on the SATCOM link to maximize information throughput over the SATCOM link while ensuring acceptable signal quality under varying rain fading conditions. Sufficient power margin is built into the SATCOM link such that, under severe rain fading conditions, the lowest system throughput rate still provides acceptable signal quality. Under lesser rain fading conditions, the data throughput rate is increased via more bandwidth efficient modulation and coding schemes permitted by the higher signal quality which results from greater power margin. The earth station hub and remote terminals monitor the signal quality and communicate to adaptively adjust the modulation and coding used on the forward and return links to maximize information throughput under varying rain fading conditions.
    Type: Application
    Filed: August 8, 2002
    Publication date: March 20, 2003
    Inventors: Lawrence W. Krebs, Robert J. Sims, Ronald C. Bruno, Christopher Jason Berger