Patents by Inventor Robert J. Skene

Robert J. Skene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted isoindoles as glucokinase activators
    Patent number: 8394843
    Abstract: Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: March 12, 2013
    Assignee: Takeda California, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Robert J. Skene, Mingnam Tang, Sheldon X. Cao, David J. Hossfield, Jeffrey A. Stafford
  • GLUCOKINASE ACTIVATORS
    Publication number: 20110275665
    Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 10, 2011
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, David J. Hosfield, Robert J. Skene, Jeffrey A. Stafford, Mingnam Tang
  • Substituted indazoles as glucokinase activators
    Patent number: 8008332
    Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 30, 2011
    Assignee: Takeda San Diego, Inc.
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, David J. Hosfield, Robert J. Skene, Jeffrey A. Stafford, Mingnam Tang
  • Histone deacetylase inhibitors
    Patent number: 7642275
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: January 5, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jerome C. Bressi, Jason W. Brown, Robert J. Skene, Jeffrey A. Stafford, Phong H. Vu, Anthony R. Gangloff, Andrew J. Jennings, Stephen W. Kaldor
  • Crystallization of histone deacetylase 2
    Patent number: 7507552
    Abstract: Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: March 24, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Mark T. Hilgers, Mark W. Knuth, Marc E. Navre, Bi Ching Sang, Robert J. Skene, Leslie W. Tari, Keith P. Wilson, Darbi Witmer, Hua Zou
  • Crystallization of dipeptidyl peptidase IV (DPPIV)
    Patent number: 7344852
    Abstract: Provided are crystals relating to DPPIV and its various uses.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: March 18, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Kathleen Aertgeerts, Ciaran N. Cronin, David J. Hosfield, Mark W. Knuth, Duncan E. McRee, Sridhar Prasad, Bi Ching Sang, Robert J. Skene, Robert A. Wijnands, Sheng Ye
  • Crystallization of cathepsin S
    Patent number: 7319016
    Abstract: Provided are crystals relating to Cathepsin S and its various uses.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 15, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Douglas R. Dougan, Mark W. Knuth, Duncan E. McRee, Bi Ching Sang, Robert J. Skene, Ronald V. Swanson, Leslie W. Tari, Robert A. Wijnands
  • Crystallization of MvaS (HMG-CoA Synthase)
    Patent number: 7252930
    Abstract: Provided are crystals relating to MvaS (HMG-CoA Synthase) and its various uses.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: August 7, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, David J. Hosfield, Robert J. Skene, Leslie W. Tari, Sheng Ye
  • Crystallization of 11-Beta-Hydroxysteroid Dehydrogenase type 1
    Patent number: 7241604
    Abstract: Provided are crystals relating to 11-Beta-Hydroxysteroid Dehydrogenase type 1 and its various uses.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: July 10, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Kathleen Aertgeerts, Oleg Brodsky, Ellen Chi, Mark T. Hilgers, David J. Hosfield, Robert J. Skene
  • Crystal structure of MvaS
    Patent number: 7076372
    Abstract: Provided are structure coordinates relating to MvaS and its various uses.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: July 11, 2006
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, David J. Hosfield, Robert J. Skene, Leslie W. Tari, Sheng Ye