Patents by Inventor Robert J. Steffan

Robert J. Steffan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10514124
    Abstract: A plug for sealing an interior of a tube and including a cylindrical body having a first end that is open and includes an annular surface, and a second end that is closed by a conical end wall. The cylindrical body having a plurality of ribs that are configured to engage the interior of the tube and provide a seal between the plug and the interior of the tube. The plug also includes a handle unitary with the cylindrical body that extends from the annular surface. The handle has a cylindrical inner surface that is coextensive with an interior surface of the cylindrical body and an outer surface that is coextensive with an exterior surface of the cylindrical body.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: December 24, 2019
    Assignee: Mueller Industries, Inc.
    Inventors: John Webb, Michael Baum, Christie Shumpert, Robert Merrill Sutton, Christopher Charles Saylor, Kenneth Mark Shane, Daniel J. Steffan
  • Patent number: 7592363
    Abstract: This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: September 22, 2009
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Edward M. Matelan, Stephen M. Bowen, John W. Ullrich, Jay E. Wrobel, Edouard Zamaratski, Lars Kruger, Annabel L. Olsen Hedemyr, Aiping Cheng, Tomas Hansson, Rayomand J. Unwalla, Christopher P. Miller, Patrik P. Rhönnstad
  • Patent number: 7241791
    Abstract: This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: July 10, 2007
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Edward M. Matelan, Mark A. Ashwell, William R. Solvibile
  • Patent number: 7169591
    Abstract: A method for converting alkenes into epoxides and, particularly, to convert alkenes into enantio-specific epoxides by the use of enzymes which may be in their naturally-occuring (native) form or in mutated form, such as a native or mutated non-haem diiron-containing monooxygenase, and novel compounds produced thereby.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: January 30, 2007
    Assignee: Shaw Environmental & Infrastructure, Inc.
    Inventors: Robert J. Steffan, Kevin R. McClay
  • Patent number: 6936630
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is wherein R9, R10, R11, R12, R13, and R14 are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R6, and R7 are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH2COOR8, where R8 is a lower alkyl of 1-6 carbon atoms; and X is O or S; R1 is hydrogen or a lower alkyl of 1-6 carbon atoms; R2, R3, and R4 are each, independently, hydrogen or halogen; and R5 is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 30, 2005
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Publication number: 20040167127
    Abstract: This invention provides compound of formulae I or II having the structure 1
    Type: Application
    Filed: September 24, 2003
    Publication date: August 26, 2004
    Applicant: Wyeth
    Inventors: Robert J. Steffan, Edward M. Matelan, Mark A. Ashwell, William R. Solvibile
  • Publication number: 20040127526
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 1, 2004
    Applicant: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 6686476
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is wherein R9, R10, R11, R12, R13, and R14 are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R6, and R7 are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH2COOR8, where R8 is a lower alkyl of 1-6 carbon atoms; and X is O or S; R1 is hydrogen or a lower alkyl of 1-6 carbon atoms; R2, R3, and R4 are each, independently, hydrogen or halogen; and R5 is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: February 3, 2004
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 6620807
    Abstract: The present invention provides benzoheterocyclic carboxyamides, particularly pyridobenzodiazepine and pyridobenzoxazepine carboxyamides, of the general formula: wherein: W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for providing a temporary delay of urination or for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding or coagulation disorders.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: September 16, 2003
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 6524842
    Abstract: A method for degrading an undesirable ether-based environmental contaminant by contacting the ether with a hydrogen-oxidizing microorganism to convert the ether to innocuous compounds which are environmentally acceptable, including treating the ether-based contaminants in situ or removing them from the contaminated site for treatment in a bioreactor, examples of the ether-based contaminants being tertiary butyl ethers of the type utilized as gasoline oxygenates, for example, methyl tert-butyl ether, ethyl tert-butyl ether, and methyl tert-amyl ether, and also ether solvents, for example, tetrahydrofuran.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: February 25, 2003
    Assignee: Envirogen, Inc.
    Inventors: Simon Vainberg, Robert J. Steffan
  • Publication number: 20030013747
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: 1
    Type: Application
    Filed: August 6, 2002
    Publication date: January 16, 2003
    Applicant: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 6455566
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is  wherein R9, R10, R11, R12, R13, and R14 are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R6, and R7 are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH2COOR8, where R8 is a lower alkyl of 1-6 carbon atoms; and X is O or S; R1 is hydrogen or a lower alkyl of 1-6 carbon atoms; R2, R3, and R4 are each, independently, hydrogen or halogen; and R5 is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: September 24, 2002
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Publication number: 20020037907
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: March 28, 2002
    Applicant: American Home Products Corporation
    Inventors: Robert J. Steffan, Mark A. Ashwell, Jeffrey C. Pelletier, William R. Solvibile, Edward M. Matelan
  • Patent number: 6344451
    Abstract: The present invention provides compounds of the formula: wherein: X, Y and Z are independently selected from O, S, CH, CH2, N, or NR4; W is moiety selected from (CH2)n; n=1-2; R1, R2 are independently, hydrogen, straight chain alkyl (C1-C6), branched chain alkyl (C3-C7), cycloalkyl (C3-C7), alkoxyalkyl (C2-C7), halogen, straight or branched chain alkoxy (C1-C6), hydroxy, CF3, or perfluoroalkyl (C2-C6); R3 is hydrogen or a straight chain alkyl group (C1-C6), branched chain alkyl (C3-C7), cycloalkyl (C3-C7), alkoxyalkyl (C2-C7), or hydroxyalkyl (C1-C6); R4 is selected from hydrogen, or (lower alkyl (C1-C6); and R5 is selected from halogen or hydrogen; or a pharmaceutically acceptable salt thereof: as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation dis
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: February 5, 2002
    Assignee: American Home Products
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 6268364
    Abstract: This invention provides compounds of formula 1 having the structure wherein R1, R2, R3, R4, and R5 are each independently, hydrogen, halogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenylalkyl, alkoxy, aryloxy, fluoroalkoxy, trifluoromethyl, alkylthio, alkylsulfony, —SCF3, nitro, alkylamino, or dialkylamino; R6 is hydrogen, alkyl, cycloalkyl, or arylalkyl; and R7 is alkyl, cycloalkyl, or arylalkyl or a pharmaceutically acceptable salt thereof which are useful as antiatherosclerotic agents.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: July 31, 2001
    Assignee: American Home Products Corporation
    Inventors: Kevin A. Memoli, Donald P. Strike, Amedeo A. Failli, Robert J. Steffan
  • Patent number: 6194407
    Abstract: The present invention provides compounds of the general formula: wherein W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: February 27, 2001
    Assignee: American Home Products Corporation
    Inventors: Amedeo A. Failli, Jay S. Shumsky, Robert J. Steffan
  • Patent number: 6160114
    Abstract: This invention provides compounds of formula 1 having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are each independently, hydrogen, halogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenylalkyl, alkoxy, aryloxy, fluoroalkoxy, trifluoromethyl, alkylthio, alkylsulfony, --SCF.sub.3, nitro, alkylamino, or dialkylamino;R.sup.6 is hydrogen, alkyl, cycloalkyl, or arylalkyl; andR.sup.7 is alkyl, cycloalkyl, or arylalkylor a pharmaceutically acceptable salt thereof which are useful as antiatherosclerotic agents.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 12, 2000
    Assignee: American Home Products Corporation
    Inventors: Kevin A. Memoli, Donald P. Strike, Amedeo A. Failli, Robert J. Steffan
  • Patent number: 6090803
    Abstract: The present invention provides compounds of the general formula: ##STR1## wherein W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: July 18, 2000
    Assignee: American Home Products Corporation
    Inventors: Amedeo A. Failli, Jay S. Shumsky, Robert J. Steffan
  • Patent number: 6011053
    Abstract: Antiatherosclerotic agents are provided having the structure: ##STR1## wherein R is a lower alkyl of 1-6 carbon atoms, ##STR2## wherein R.sub.5, R.sub.6, and R.sub.7 are lower alkyl of 1-6 carbon atoms; and R.sub.8, R.sub.9 and R.sub.10 are each, independently, hydrogen or halogen;R.sub.1 and R.sub.2 are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; andR.sub.3 and R.sub.4 are each, independently, hydrogen, a lower alkyl of 1-6 carbon atoms or halogen;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: January 4, 2000
    Assignee: American Home Products Corporation
    Inventors: Robert J. Steffan, Amedeo A. Failli
  • Patent number: 5830911
    Abstract: This invention provides compounds of formula I having the structure ##STR1## wherein R is (CH.sub.2).sub.n COOR.sup.4 ;R.sup.1 is hydrogen, alkyl, alkenyl, alkynyl, alkylcycloalkyl, and alkoxyalkyl;R.sup.4 is hydrogen or alkyl;R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, arylalkoxy, fluoroalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, nitro, --SCF.sub.3, --COR.sup.3, alkanoyloxy, hydroxy, trifluoromethyl, amino, alkylamino, dialkylamino, alkylamido, or alkylsulfonamido; wherein at least one of R.sup.5, R.sup.6, R.sup.7, or R.sup.8 is cyano;R.sup.3 is alkyl, hydroxy, alkoxy, amino, alkylamino;X is --O-- or --C--; andn=1-4or a pharmaceutically acceptable salt thereof, which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: November 3, 1998
    Assignee: American Home Products Corporation
    Inventors: Amedeo A. Failli, Robert J. Steffan, Anthony F. Kreft, Thomas J. Caggiano, Craig E. Caufield