Abstract: Compounds of the formula ##STR1## wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R.sub.1 is primary or secondary alkyl of 1 to 5 carbon atoms, andR.sub.2 is hydrogen, chloro or bromo,And the pharmaceutically acceptable acid addition salts thereof, are useful as anti-obesity and anti-diabetic agents. The compounds wherein R and R' are tertiary alkyl of 4 to 7 carbon atoms and R.sub.2 is hydrogen are synthesized from ketenimines and amidines, all of the compounds wherein R.sub.2 is hydrogen are synthesized by reduction of the corresponding 3-cyanopyridines, and the compounds wherein R.sub.2 is chloro or bromo are synthesized from the corresponding compounds wherein R.sub.2 is hydrogen and an N-halosuccinimide.

Abstract: Compounds of the formula ##STR1## wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R.sub.1 is alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, chloro or bromo, andR.sub.3 is hydrogen, --CO--R.sub.4 or cyano,Wherein R.sub.4 is alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, ##STR2## OR AMINO, WHEREIN EACH X is independently alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halo or two X's on adjacent carbon atoms together are methylenedioxy, with the proviso that the ortho positions of the phenyl ring are free of halo substituents, andn is 0, 1, 2 or 3,And the pharmaceutically acceptable acid addition salts thereof,Are useful as anti-obesity and anti-diabetic agents. The compounds wherein R.sub.2 is hydrogen and R.sub.3 is alkylcarbonyl, benzoyl or substituted benzoyl are synthesized from ketoketenimines and amidines while those wherein R.sub.