Abstract: A device for joining two layers of tissue, comprises a substantially flat and flexible scaffold having an upper surface, a lower surface and sidewalls; a plurality of first passages penetrating said scaffold from said upper surface to said lower surface; a plurality of second passages penetrating said scaffold from said upper surface to said lower surface; a substantially flat and flexible top cover releasably attached to said upper surface and covering all of said upper surface; said top cover having a plurality of top cover passages aligned with said first plurality of passages.

Abstract: Novel recessed surgical fastening devices are disclosed. The fastening devices have a compressible member and a fastening element disposed at least partially within the compressible member. The fastening element has at least one tissue engagement member that is extensible through the compressible member to engage tissue when a force is applied to the fastening device.

Abstract: An implantable medical device and method of making it, including a collection of filaments, including a plurality of first variety filaments made of a first polymeric material and at least one second variety filament, and optionally at least one third variety of filament, wherein the second variety filament is coated or impregnated with a first biomedically useful agent and, if present, the third variety of filament is coated or impregnated with a second biomedically useful agent different from the first biomedically useful agent.

Abstract: The present invention is directed to linear surgical staplers for joining tissue layers comprising a disposable cartridge installed in a first jaw connected to an opposing second jaw, said cartridge containing a plurality of deployable staples in arrays separated by a tissue resection slot and a plurality of resorbable medicant-releasing microneedles, said microneedles comprising elongated rods having a sharp tissue-penetrating distal end and a proximal end; said microneedles are releasably disposed on or within a tissue-facing surface of the cartridge, wherein the proximal end of the microneedles is supported on the cartridge. The present invention is also directed to methods of use of such stapler assembly devices.

Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an isolated enclosure around the stapled and resected tissues at the anastomotic joint.

Abstract: A scaffold for joining two layers of tissue, comprises a substantially flat and flexible body having a top surface, a bottom surface and sidewalls; at least one channel within the body starting at an injection port; a plurality of first passages on the top surface and a plurality of second passages on the bottom surface, said passages in fluid communication with the channel; a plurality of third passages penetrating the body from the top surface to the bottom surface, said plurality of third passages not in fluid communication with the channel.

Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves having compressible/expandable rings, deployed from such stapling instruments and establishing an isolated enclosure around the stapled and resected tissues at the anastomotic joint.

Abstract: The present invention relates to surgical instruments and a method for applying an adhesive or sealant to an anastomosis site immediately prior and/or during anastomotic surgical stapling. The present invention further relates to surgical instruments, devices, and methods for applying sealant to a target tissue of a surgical site being anastomotically joined so as to prevent leakage.

Abstract: A novel single plane tissue repair patch is disclosed. The patch has a base member with an opening therethrough, and a closure member associated with the opening. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.

Abstract: A novel single plane tissue repair patch is disclosed. The patch has a base member with an opening therethrough, and a closure member associated with the opening. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.

Abstract: Novel deployment devices for use as adjuncts with tissue repair implants. The devices are removeably mounted to mesh tissue repair implant devices to manipulate the devices into position and provide for secure fixation about the periphery of such mesh implant devices by providing guide structures such as grooves for directing and positioning a surgical tacking instrument.

Abstract: An expandable mammary implant including a shell having an anterior face and a posterior face. The anterior has an upper pole portion and a lower pole portion meeting at an apex, and an injection zone for receiving fluid therethrough to inflate the implant. A reinforcement material is coupled to the shell in a reinforcement zone. The reinforcement material is coupled to the shell so as to at least coincide with the upper pole portion and a peripheral rim portion that extends from the posterior face upwardly into said anterior face by a predetermined distance.

Abstract: The present invention is directed to a spray applicator for spraying a tissue treatment medicant onto a tissue that has a container containing the medicant and is positioned at a proximal end of the spray applicator; a spray tip positioned at a distal end of the spray applicator; a cannula connecting the container with the spray tip; an actuatable dispensing mechanism at a proximal end of the applicator to express the medicant from the container through the cannula and through the spray tip toward the tissue; an optional pressurized gas source discharging a gas through the cannula in the vicinity of the spray tip or inside the spray tip; and a distance indicator that provides indicia of the distance between the spray tip and the tissue but does not prevent positioning the spray tip closer to the tissue than a defined distance for the distance indicator.

Abstract: The present invention is directed to a spray applicator for spraying a tissue treatment medicant onto a tissue that has a container containing the medicant and is positioned at a proximal end of the spray applicator; a spray tip positioned at a distal end of the spray applicator; a cannula connecting the container with the spray tip; an actuatable dispensing mechanism at a proximal end of the applicator to express the medicant from the container through the cannula and through the spray tip toward the tissue; an optional pressurized gas source discharging a gas through the cannula in the vicinity of the spray tip or inside the spray tip; and a distance indicator that provides indicia of the distance between the spray tip and the tissue but does not prevent positioning the spray tip closer to the tissue than a defined distance for the distance indicator.

Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to an expandable compression device for application to anastomotically joined tubular tissues, comprising: an upper ring-shaped or disk-shaped flange at a distal end of said device connected to a lower ring-shaped inflatable flange at a proximal end of said device via a hollow cylindrical tubular body, with an opening forming an axial passage through said upper flange, lower flange, and tubular body.

Abstract: Systems and methods for delivering fluid within a lumen may be provided. For example, a device can include an elongated tubular structure having a central opening through which fluid may flow. The central opening can be defined by an open proximal end and an open distal end. The elongated tubular structure can have an elastic section toward the open distal end. The device can also include a blocking device such as a balloon within the central opening of the elongated tubular structure that can help or be configured to prevent the flow of fluid through the central opening between the open proximal end and the open distal end. The device can further include a balloon disposed on an outer surface of the elongated tubular structure. The balloon can be affixed to the outer surface of the elongated tubular structure at a proximal and/or distal attachment site.

Abstract: An expandable mammary implant including a shell having an anterior face and a posterior face. The anterior has an upper pole portion and a lower pole portion meeting at an apex, and an injection zone for receiving fluid therethrough to inflate the implant. A reinforcement material is coupled to the shell in a reinforcement zone. The reinforcement material is coupled to the shell so as to at least coincide with the upper pole portion and a peripheral rim portion that extends from the posterior face upwardly into said anterior face by a predetermined distance.

Abstract: A mammary implant and method of making are provided herein. The implant includes an outer shell configured to retain fluid therein, an injection element coupled to the outer shell and adapted to receive therethrough an injection device for injecting fluid into the outer shell, and an injection marker zone made of a material having ultrasonically detectable markers incorporated therein. The markers are a plurality of microcavities that are located relative to the injection element so that, when ultrasonically detected, such detection indicates a location of the injection element.

Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of the resulting mixture from the device. The mixing device comprises a syringe having an open end and outlet and containing a first component; and a cap with a fixed outer body and an expandable chamber contained therein, wherein said cap is removably attached to the outlet of the syringe and a cross-section of the cap is larger than a syringe cross-section and the cap is shorter than the syringe.

Abstract: A mammary implant and method of making are provided herein. The implant includes an outer shell configured to retain fluid therein, an injection element coupled to the outer shell and adapted to receive therethrough an injection device for injecting fluid into the outer shell, and an injection marker zone made of a material having ultrasonically detectable markers incorporated therein. The markers are a plurality of microcavities that are located relative to the injection element so that, when ultrasonically detected, such detection indicates a location of the injection element.