Patents by Inventor Robert J. Ternansky

Robert J. Ternansky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ring-closure method for 1-carbacephalosporin six-membered ring
    Patent number: 5089610
    Abstract: The invention provides a process for preparing 7-protected amino-4-protected carboxy-1-carbacephalosporins which includes subjecting a 3-protected-amino-4-(1-propylene oxide)-methyl(protected carboxy)-azetidin-2-one to a strong base to form a 2-hydroxycepham and thereafter dehydrating the 2-hydroxycepham to form the desired 1-carbacephalosporin.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: February 18, 1992
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • C-3 phosphine oxide substituted carbacephalosporins
    Patent number: 5084447
    Abstract: This invention provides novel 3-phosphine oxide substituted 1-carba(1-dethia)cephalosporins useful as anti-microbial agents, and formulations and methods of use thereof.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: January 28, 1992
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • 3-thiazolylthio carbacephem antibacterial agents
    Patent number: 5077287
    Abstract: The present invention provides compounds of the formula ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.6 haloalkyl;A and A' are independently hydrogen, C.sub.1 -C.sub.6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2 or 3 hetero atoms selected from nitrogen or sulfur, C.sub.1 -C.sub.6 alkoxy, or phenyl; or A and A' taken together form a group of the formulae ##STR2## wherein X is hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods of treatment using the above compounds.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: December 31, 1991
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • 7-substituted bicyclic pyrazolidinones
    Patent number: 5011938
    Abstract: 7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: April 30, 1991
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Richard E. Holmes, Louis N. Jungheim, Sandra K. Sigmund, Robert J. Ternansky
  • Process for preparing 4-substituted azetidinones
    Patent number: 4992545
    Abstract: A process for preparing 3-4-cis-.beta.,.beta.-(4)-substituted and 3-4-trans,.beta.,.alpha.- (4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: February 12, 1991
    Assignee: Eli Lilly and Company
    Inventors: David A. Hall, deceased, John M. Morin, Jr., Robert J. Ternansky
  • 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
    Patent number: 4940718
    Abstract: 7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: July 10, 1990
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Richard E. Holmes, Louis N. Jungheim, Sandra K. Sigmund, Robert J. Ternansky
  • 1,2,4-trisubstituted diazolidinones
    Patent number: 4795815
    Abstract: 1,2,4-Trisubstituted diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: January 3, 1989
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • 1-(vinyl phosphonate adduct) pyrazolidinones
    Patent number: 4716232
    Abstract: 1-(Vinyl phosphonate adduct) pyrazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: December 29, 1987
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky