Patents by Inventor Robert J. Wojciechowski

Robert J. Wojciechowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11345882
    Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: May 31, 2022
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
  • Patent number: 10723993
    Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 28, 2020
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl Patrick Bongers, Scott Waniger, Beverly Norris, Mark Hirschel, Thiem Chan Duong Wong, Grant Adams, Martin Peder Crep, Michael J. Gramer
  • Patent number: 10662401
    Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: May 26, 2020
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Mark Hirschel, Robert J. Wojciechowski, Kim Arneson
  • Patent number: 10570434
    Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: February 25, 2020
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Mark Hirschel, Robert J. Wojciechowski, Grant Adams, Darrell P. Page, Kimberly Arneson, Jeff Jorgensen, Scott Waniger
  • Patent number: 10093956
    Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: October 9, 2018
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Mark Hirschel, Robert J. Wojciechowski, Grant Adams, Darrell P. Page, Kimberly Arneson, Jeff Jorgensen, Scott Waniger
  • Publication number: 20180155668
    Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
    Type: Application
    Filed: January 31, 2018
    Publication date: June 7, 2018
    Inventors: MARK HIRSCHEL, ROBERT J. WOJCIECHOWSKI, KIM ARNESON
  • Publication number: 20180155752
    Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
    Type: Application
    Filed: January 31, 2018
    Publication date: June 7, 2018
    Inventors: MARK HIRSCHEL, ROBERT J. WOJCIECHOWSKI, GRANT ADAMS, DARRELL P. PAGE, KIMBERLY ARNESON, JEFF JORGENSEN, SCOTT WANIGER
  • Patent number: 9902928
    Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: February 27, 2018
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Mark Hirschel, Robert J. Wojciechowski, Kim Arneson
  • Patent number: 9534198
    Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: January 3, 2017
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
  • Publication number: 20160362650
    Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: ROBERT J. WOJCIECHOWSKI, DARRELL P. PAGE, KARL PATRICK BONGERS, SCOTT WANIGER, BEVERLY NORRIS, MARK HIRSCHEL, THIEM CHAN DUONG WONG, GRANT ADAMS, MARTIN PEDER CREP, MICHAEL J. GRAMER
  • Publication number: 20160362652
    Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: DARRELL PAUL PAGE, ROBERT J. WOJCIECHOWSKI, MARTIN PEDER CREP
  • Patent number: 9441195
    Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: September 13, 2016
    Assignee: BIOVEST INTERNATIONAL, INC.
    Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl Patrick Bongers, Scott Waniger, Beverly Norris, Mark Hirschel, Thiem Chan Duong Wong, Grant Adams, Martin Peder Crep, Michael J. Gramer
  • Publication number: 20150225685
    Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
    Type: Application
    Filed: August 28, 2013
    Publication date: August 13, 2015
    Inventors: Mark Hirschel, Robert J. Wojciechowski, Kimberly Arneson
  • Publication number: 20150175950
    Abstract: The invention concerns a bioreactor for production of virus and virus-like particles (VLPs), methods for production of virus and VLPs, methods for regulating the concentration of molecules inhibitory to viral and VLP yield in a cell culture chamber of a bioreactor, such as the extracapillary space of a hollow fiber bioreactor.
    Type: Application
    Filed: October 30, 2014
    Publication date: June 25, 2015
    Inventors: MARK HIRSCHEL, ROBERT J. WOJCIECHOWSKI, JOSEPH DAVID GANGEMI, SCOTT WANIGER, KEVIN TACHENY, CHAD SINKLER, DARRELL P. PAGE, JEFF JORGENSEN, MICHAEL J. GRAMER, KIMBERLY ARNESON, GRANT ADAMS
  • Publication number: 20150111252
    Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: MARK HIRSCHEL, ROBERT J. WOJCIECHOWSKI, MICHAEL J. GRAMER, GRANT ADAMS, DARRELL P. PAGE, CHAD SINKLER, KEVIN TACHENY, KIMBERLY ARNESON, JEFF JORGENSEN, SCOTT WANIGER
  • Publication number: 20140024012
    Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 23, 2014
    Inventors: DARRELL PAUL PAGE, ROBERT J. WOJCIECHOWSKI, MARTIN PEDER CREP
  • Patent number: 8540499
    Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: September 24, 2013
    Assignee: Biovest International, Inc.
    Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
  • Patent number: 8383397
    Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: February 26, 2013
    Assignee: Biovest International, Inc.
    Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl P. Bongers, Scott T. Waniger, Beverly Norris, Mark D. Hirschel, Thiem Chan Duong Wong, Martin P. Crep, Michael J. Gramer, Grant Adams
  • Publication number: 20110212493
    Abstract: The present invention includes perfusion bioreactors, automated cell culture systems, and methods for production of cells and cell-derived products.
    Type: Application
    Filed: April 22, 2011
    Publication date: September 1, 2011
    Applicant: BIOVEST INTERNATIONAL, INC.
    Inventors: Mark HIRSCHEL, Darrell P. PAGE, Robert J. WOJCIECHOWSKI
  • Publication number: 20090269841
    Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
    Type: Application
    Filed: November 20, 2008
    Publication date: October 29, 2009
    Applicant: Biovest International, Inc.
    Inventors: Robert J. Wojciechowski, Darrell Paul Page, Karl Patrick Bongers, Scott Thomas Waniger, Beverly Norris, Mark D. Hirschel, Thiem Chan Duong Wong, Martin Peder Crep, Michael J. Gramer, Grant Adams