Abstract: Multilayer films and adhesive tapes that include such films, wherein the multilayer films include plasticized polyvinyl chloride and optionally one or more fillers.

Abstract: A mammalian cell comprising at least four distinct recombination target sites (RTS), an adenovirus (Ad) gene comprising E1A, E1B or a combination thereof, and a promoter operatively linked to the Ad gene, wherein the RTS, the Ad gene, and the promoter are chromosomally-integrated; methods for using the cell for generating a recombinant adeno-associated virus (rAAV) producer host cell; and methods for using the AAV producer host cell to produce, package and purify rAAV.

Abstract: The current disclosure provides methods for reprogramming mammalian somatic cells by regulating the expression of endogenous cellular genes. Cellular reprogramming of somatic cells can be induced by activating the transcription of embryonic stem cell-associated genes (e.g., oct3/4) and suppressing the transcription of somatic cell-specific and/or cell death-associated genes. The endogenous transcription machinery can be modulated using synthetic transcription factors (activators and suppressors), to allow for faster, and more efficient nuclear reprogramming under conditions amenable for clinical and commercial applications. The current disclosure further provides cells obtained from such methods, along with therapeutic methods for using such cells for the treatment of diseases amendable to stem cell therapy, as well as kits for such uses.

Abstract: The current disclosure provides methods for reprogramming mammalian somatic cells by regulating the expression of endogenous cellular genes. Cellular reprogramming of somatic cells can be induced by activating the transcription of embryonic stem cell-associated genes (e.g., oct3/4) and suppressing the transcription of somatic cell-specific and/or cell death-associated genes. The endogenous transcription machinery can be modulated using synthetic transcription factors (activators and suppressors), to allow for faster, and more efficient nuclear reprogramming under conditions amenable for clinical and commercial applications. The current disclosure further provides cells obtained from such methods, along with therapeutic methods for using such cells for the treatment of diseases amendable to stem cell therapy, as well as kits for such uses.

Abstract: A method, apparatus and computer program product are provided for validating electronic distribution transactions and reducing non-compliant electronic distribution transactions. A distribution application enables users to enter details relating to a retirement account distribution. A tax service integrated with the distribution application provides scenario-specific tax withholding information, and enforces relevant tax withholding rules. A user provides withholding information and the system ensures compliance by validating the transaction against the withholding rules. The system displays to the user any errors that need to be corrected, and a breakdown of the proceeds from the transaction. The tax service is implemented remotely from the distribution application so that changing tax regulations may be implemented into the tax service without impacting the distribution application.

Abstract: The current disclosure provides methods for reprogramming mammalian somatic cells by regulating the expression of endogenous cellular genes. Cellular reprogramming of somatic cells can be induced by activating the transcription of embryonic stem cell-associated genes (e.g., oct3/4) and suppressing the transcription of somatic cell-specific and/or cell death-associated genes. The endogenous transcription machinery can be modulated using synthetic transcription factors (activators and suppressors), to allow for faster, and more efficient nuclear reprogramming under conditions amenable for clinical and commercial applications. The current disclosure further provides cells obtained from such methods, along with therapeutic methods for using such cells for the treatment of diseases amendable to stem cell therapy, as well as kits for such uses.

Abstract: The present disclosure relates to a site-specific integration (SSI) mammalian cell that comprises at least two distinct recombination target sites (RTS) wherein two RTS are chromosomally-integrated within the NL1 locus or the NL2 locus. The disclosure also relates to a SSI mammalian cell comprising at least four distinct RTS wherein two RTS are chromosomally-integrated within the NL1 or the NL2 locus and two RTS are chromosomally-integrated within a separate locus. The disclosure also relates to methods for using the SSI mammalian cell to produce recombinant protein expression cell lines that can express difficult to express proteins.

Abstract: A mammalian cell comprising at least four distinct recombination target sites (RTS), an adenovirus (Ad) gene comprising E1A, E1B or a combination thereof, and a promoter operatively linked to the Ad gene, wherein the RTS, the Ad gene, and the promoter are chromosomally-integrated; methods for using the cell for generating a recombinant adeno-associated virus (rAAV) producer host cell; and methods for using the AAV producer host cell to produce, package and purify rAAV.

Abstract: The invention relates generally to methods of generating induced pluripotent stem cells (iPSCs) that do not contain the reprogramming vector. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing an episomal vector(s) comprising at least one expression cassette containing reprogramming factors and/or synthetic transcription factors and a suicide gene. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing episomal vector(s) comprising expression cassettes containing reprogramming factors and/or synthetic transcription factors and a transcriptionally regulated EBNA-1 gene. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing episomal vector(s) comprising expression cassettes containing reprogramming factors and/or synthetic transcription factors and both a suicide gene and a transcriptionally regulated EBNA-1 gene.

Abstract: The current disclosure provides methods for reprogramming mammalian somatic cells by regulating the expression of endogenous cellular genes. Cellular reprogramming of somatic cells can be induced by activating the transcription of embryonic stem cell-associated genes (e.g., oct3/4) and suppressing the transcription of somatic cell-specific and/or cell death-associated genes. The endogenous transcription machinery can be modulated using synthetic transcription factors (activators and suppressors), to allow for faster, and more efficient nuclear reprogramming under conditions amenable for clinical and commercial applications. The current disclosure further provides cells obtained from such methods, along with therapeutic methods for using such cells for the treatment of diseases amendable to stem cell therapy, as well as kits for such uses.

Abstract: In one implementation, a device for dispensing items includes a plurality of compartments for storing medicines or medical supplies, a respective light source associated with each of the plurality of compartments, and a computerized controller coupled to the light sources. The computerized controller maintains an inventory of the contents of the plurality of compartments and receives requests to dispense medicines or medical supplies from the plurality of compartments. In response to a request to dispense a particular medicine or medical supply item, the computerized controller illuminates the light source associated with the compartment holding the particular medicine or medical supply item, the light source being illuminated with a brightness controlled by the computerized controller. The brightness of the light source may be controlled in accordance with a detected brightness of the ambient environment. The light source may be a multi-colored light source.

Abstract: A condensate trap for a condensing boiler has a generally hollow body for receiving condensate from a heat exchanger of the condensing boiler and for providing a path of flow for condensate out of the side of the boiler. The body of the condensate trap includes a condensate receiving end having an inlet, a condensate discharging end having an outlet, and an intermediate reversely-turned trap portion interconnecting the condensate receiving and discharging ends. The hollow body can be one-piece and molded of plastic. A level sensor can be mounted on or within the condensate receiving end of the body. In a preferred embodiment, the condensate receiving end includes a chamber with an opening, and the level sensor extends within the chamber and seals the opening. The condensate trap can also include an air vent located above the level sensor in communication with an air pressure sensor.

Abstract: Embodiments of the invention address deficiencies of the art in respect to content delivery over a telephone call and provide a method, system and computer program product for delivering targeted content to a caller during call processing of an inbound telephone call. In an embodiment of the invention, a method for delivering targeted content to a caller during call processing of an inbound telephone call can include receiving a telephone call from a caller in a call handling system and identifying a telephone number for the telephone call from information contained in the telephone call. The method also can include determining a location corresponding to the telephone number and matching the determined location to content stored in a data store of content. Finally, the method can include retrieving the matched content from the data store of content, and delivering the matched content to the caller.

Abstract: There is disclosed a modular power distribution center that utilizes connectors for interconnectivity, as opposed to hard wiring and allows for the integration of electronics modules onto printed circuit board architecture.

Abstract: A condensate trap for a condensing boiler has a generally hollow body for receiving condensate from a heat exchanger of the condensing boiler and for providing a path of flow for condensate out of the side of the boiler. The body of the condensate trap includes a condensate receiving end having an inlet, a condensate discharging end having an outlet, and an intermediate reversely-turned trap portion interconnecting the condensate receiving and discharging ends. The hollow body can be one-piece and molded of plastic. A level sensor can be mounted on or within the condensate receiving end of the body. In a preferred embodiment, the condensate receiving end includes a chamber with an opening, and the level sensor extends within the chamber and seals the opening. The condensate trap can also include an air vent located above the level sensor in communication with an air pressure sensor.

Abstract: The present disclosure provides for affording synchronization in an automated scripting framework. First, script data is received utilizing a language-driven interface. Then, reports having user readable sentences are created based on the received script data. The received script data is then translated into automation code. Finally, automated testing is provided utilizing the automation code.

Abstract: There is disclosed a modular power distribution center that utilizes connectors for interconnectivity, as opposed to hard wiring and allows for the integration of electronics modules onto printed circuit board architecture.

Abstract: The present invention provides a battery module system including a plurality of battery modules in a series electrical connection through a specified sequence, each battery module having a male connector and a female connector, the female connector of each battery module in electrical engagement into the male connector of an adjacent battery module, wherein the male connector and female connector are positioned along the sidewall of each battery module and have insulating structures that protect handlers of the battery modules from high voltage electrocution. The present invention also provides a battery module system in which the male and female connectors are attached to a top surface of each battery module.

Abstract: To test the functionality of a computer system, automated testing may use an automation testing tool that emulates user interactions. A database may store words each having a colloquial meaning that is understood by a general population. For each of these words, the database may store associated computer instructions that can be executed to cause a computer to perform the function that is related to the meaning of the word. During testing, a word may be received having a colloquial meaning that is understood by a general population. The database may be queried for the received word and the set of computer instructions may be returned by the database. The automated testing tool may then perform the function returned to the colloquial meaning of the word. The words stored in the database may be in English or another language.

Abstract: A system, method and article of manufacture are provided for affording test maintenance in an automated scripting framework. First, a plurality of test scripts are developed. Then, the plurality of test scripts are stored in a centrally located database. A user is then allowed to edit a specific test script located on the centrally located database. Finally, the user edits to the specific test script are propagated to each of the plurality of test scripts.