Abstract: This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.

Abstract: A computer tablet includes a wireless receiver, and a pen is configured to be manipulated by a person to ride against the computer tablet and thereby provide input to the computer tablet. The pen includes a wireless transmitter. A processor associated with the computer tablet outputs an alarm when a signal from the transmitter of the pen is not sensed by the computer tablet within a time period.

Abstract: Compounds of formula I: wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

Abstract: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit ? secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.

Abstract: Acetylcholine receptor ligands of formula (I), wherein D, Ar1, E and Ar2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Abstract: Acetylcholine receptor ligands of formula I wherein D, E and G are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Abstract: A single piece body foldable along hinges between a three-dimensional generally closed configuration and a generally rectangular two-dimensional configuration. The body includes a plurality of components. The components are foldably interconnected through lateral and longitudinal hinges. A display face is provided on one side of body. A number of separate permanent magnets are embedded within the body Some of permanent magnets are positioned to magnetically interengage one another when the body is in the three-dimensional generally closed configuration. Some or all of the permanent magnets serve to retain objects in various predetermined locations on the display face when the body is in the generally rectangular two-dimensional configuration. An object collector is provided for collecting magnet containing playing pieces from the display face. The object collector is designed to be grasped by a user and dragged across the display face to magnetically collect the playing pieces.

Abstract: Compounds of formula (I), wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

Abstract: Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Abstract: A method for utilizing a graphical user interface for concurrent programming of multiple feature operations to a single production job in a controller for a production system includes presenting options on the user interface for the selection of job properties or queue properties, with queue properties defined as default values for the virtual device to which the job will be submitted and job properties defined as job feature selection options. The job feature selection options may be hidden or displayed to enable the selection of valid job feature combinations only. Toggle controls are utilized for job feature options whose operation is limited by previously selected job feature options. The application of any valid combination of selected job feature options on the completed production job is illustrated on a dynamic graphic.

Abstract: Source script (250, 260, 270) on multiple user portals is collaboratively manipulated by exchanging metadata (210) among the plurality of user portals to represent chosen segments of the source script. The metadata (210) contains properties (230-241) for the chosen segments of the source script. A common copy (250, 260, 270) of source script possessed among the plurality of user portals is initially identified. The source script, therefore, does not need to be transmitted among user portals during the collaboration because only the metadata for the common source script needs to be exchanged.

Abstract: Compounds according to Formula (I) below: wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Abstract: Apparatus and systems, as well as methods and articles, may operate to receive an indication that a housing having an integrated auxiliary display and a memory forming a portion of a redundant array disk storage has been inserted into a recessed housing compartment of a portable computer having an integrated primary display, and to execute a storage operation using the redundant array disk storage.

Abstract: A method (and system) for guaranteeing authenticity of an object, includes providing a sample of material obtainable only by at least one of chemical and physical processes such that the sample is random and not reproducible, associating a number reproducibly to the sample by using a specific reader, and forming at least one coded version of the number, the at least one coded version being obtained by a key signature, and the version being recorded into an area of the object.

Abstract: Provided herein is a compound of the formula (I), wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

Abstract: According to some embodiments, systems and apparatus for enhanced mobile computing platforms are provided. For example, an apparatus or system may comprise a universal computational package, comprising a processor, a memory coupled to the processor, a plurality of instructions stored in the memory directed to at least one specific use of the universal computational package, and a plurality of interface controllers coupled to the processor, wherein each of the plurality of interface controllers is operable to cause the processor to execute the plurality of stored instructions in accordance with the presence of a use-specific user interface cover associated with the at least one specific use of the universal computational package.

Abstract: A transponder has a resonant RLC circuit with one or more electromagnetic energy storage components that vary in response to an externally applied modulating energy field. In addition to the externally modulating energy field, a base station transmits a carrier signal with a frequency essentially the same as the quiescent resonant frequency of the RLC circuit. As the component(s) vary, the resonant frequency of the RLC circuit changes, modulating the carrier signal with the external modulating energy field. Effects of the modulation are detected by the base station. Information (e.g., the presence of a tag) is obtained by receiving and demodulating the modulated signal at the base station. One or more or the circuit elements (e.g, different preferred embodiments of one or more capacitors, inductors, and resistors) can be varied (e.g. mechanically) to modulate the carrier signal.

Abstract: This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid ?-protein production such as Alzheimer's disease.

Abstract: A computer program for estimating underground piping systems operates as a condensed spreadsheet having predetermined user-defined default values. A rough cost estimate is produced by the user making an original selection and then entering as few as two data columns, an item name and an item quantity. A single six-page report is generated having the first two pages displaying costs, the following three pages displaying backup data and the sixth page providing user comments. Eight items common to the field are categorized and appear in data sheets. Estimation formulas are substituted for large data tables. The program stores data input and/or updated by the user, interpolates or extrapolates for items not provided with specific criteria and provides user designated rounding factors and tax factors for calculating costs.

Abstract: A new cultivar of Heliconia plant named ‘Lars’ that is characterized by a compact habit and small orange flowers that bloom throughout the entire year.