Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: The field of invention relates to ice auger that connects a standard battery operated drill to an adapter that connects a standard battery operated drill to an ice auger. Description of the prior art—Ice augers are known in the prior art and have been extensively utilized by fisherman during winter. To the best of my knowledge, there are no other patents comparable to the Easy Auger Adapter.

Abstract: In one aspect of the invention, a locking assembly for a wellbore valve is provided comprising a cylindrical sleeve insertable into an interior of the valve. After insertion into the valve, the body is expanded into interference with a closing mechanism of the valve, thereby locking the valve in an open position.

Abstract: This invention relates to Interleukin-12 fusion proteins and nucleic acid constructs encoding them, and to the use of such fusion proteins and constructs in tumour therapy, especially therapy of leukaemia. More particularly it relates to carrying out such therapy by means of cell therapy.