Abstract: A method of determining premalignant or neoplastic disease state in a tissue sample containing cells of the cervix, the method comprising contacting specific monoclonal antibodies to a cervical tissue sample, determining binding of the antibodies to the sample and comparing the binding with a pattern of binding of the same antibodies to a normal cervical cell sample. Hybridomas which produce suitable antibodies have been deposited at the European Collection of Animal Cell Cultures (ECACC) under the accession numbers ECACC 95020718, 95020716, 95020720, 95020717 and 95020719.

Abstract: A method of determining abnormality in a tissue sample containing cells of the cervix the method comprising determining binding of specific binding substances to the sample and comparing the binding with the pattern of binding of said specific binding substances to a normal cervical cell sample. The specific binding substances may be antibodies. Hybridomas which produce suitable antibodies have been deposited at the European Collection of Animal Cell Cultures (ECACC), Centre for Applied Microbiology & Research, Salisbury, Wiltshire SP4 0JG, United Kingdom on Feb. 6, 1995 under the accession numbers ECACC 95020718, 95020716, 95020720, 95020717 and 95020719.