Abstract: FIG. 2A shows an alignment and sealing arrangement for connecting two non-gender opposed conduit parts (20) and (20'). Seal (22) is captured by two opposed seal protrusions (20C) and (20C') residing on conduit part's end. Bore (18A) of alignment element (18) closely receives opposed alignment protrusions located on conduit parts' end. The alignment protrusions are substantially referenced to their respective passageways. Axial force is applied to displace opposed conduit parts toward one another to cause seal protrusions to compress seal, drawing conduit parts' passageways (20E) and (20E') into an aligned relation, and reducing adjacent mating faces into approximate flush relation with one intersection (30). This coupling has one seal removed from direct contact with media, eliminates any appreciable media entrapment space, and desirably reduces flow disturbance along passageways of conduits.