Patents by Inventor Robert James Miller

Robert James Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12161760
    Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 10, 2024
    Assignee: SIGILON THERAPEUTICS, INC.
    Inventors: Lauren Emily Barney, Michael Beauregard, Guillaume Carmona, Francisco Caballero Gonzalez, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller, Matthias Alexander Oberli, Owen O'Connor, David Peritt, Jared A. Sewell, Devyn McKinley Smith, Omid Veiseh, Paul Kevin Wotton
  • Patent number: 12162994
    Abstract: Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: December 10, 2024
    Assignee: SIGILON THERAPEUTICS, INC.
    Inventors: Lauren Emily Barney, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller
  • Publication number: 20240400544
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: June 3, 2022
    Publication date: December 5, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Elizabeth Mary BECK, Robert PULLIN, Gorka ETXEBARRIA JARDI, Dean STAMOS, Yvonne SCHMIDT, Joseph PONTILLO, Stephen Andrew THOMSON, David Matthew SHAW, Nadia M. AHMAD, Lidio Marx CARVALHO MEIRELES, Sarah SKERRATT, Sara S. HADIDA RUAH, Timothy Donald NEUBERT, Dennis James HURLEY, Alexander KINTZER, Steven John DURRANT, Christopher WRAY, Anisa Nizarali VIRANI, Kiri NORTH, Reece JACQUES, Mark Thomas Miller, Jinglan ZHOU, Ronald Marcellus KNEGTEL, Ewa Iwona CHUDYK, Joanne Louise PINDER, Bruno Artur SOUSA, James DODD, Michael Edward O'DONNELL, Bhairavi GALAN, Rebecca E. STEVENS
  • Publication number: 20240368135
    Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: June 3, 2022
    Publication date: November 7, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Elizabeth Mary BECK, Robert PULLIN, Gorka ETXEBARRIA JARDI, Dean STAMOS, Yvonne SCHMIDT, Joseph PONTILLO, Stephen Andrew THOMSON, David Matthew SHAW, Nadia M. AHMAD, Lidio Marx CARVALHO MEIRELES, Sarah SKERRATT, Sara S. HADIDA RUAH, Mark Thomas Miller, Timothy Donald NEUBERT, Dennis James HURLEY, Jinglan ZHOU, Alexander KINTZER, Steven John DURRANT, Christopher WRAY, Anisa Nizarali VIRANI, Kiri NORTH, James DODD, Reece JACQUES, Stephen Michael GEDDIS, Bhairavi GALAN, Ronald Marcellus KNEGTEL, Ewa Iwona CHUDYK, Joanne Louise PINDER, Bruno Artur SOUSA, Rebecca E. STEVENS, Miranda Adele WRIGHT, Heather Clare TWIN, James Jun Bon MUI
  • Publication number: 20240329321
    Abstract: Optical couplers having a gradient-index (GRIN) lens and methods of their fabrication are disclosed. In one embodiment, a method of fabricating an expanded beam coupler for propagating an optical signal having a wavelength includes attaching a gradient-index lens to an end-face of an optical fiber, the gradient-index lens having a pitch length that is less than one-quarter, and applying optical radiation to the gradient-index lens until the pitch length of the gradient-index lens is one-quarter.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 3, 2024
    Inventors: William James Miller, Robert Adam Modavis
  • Publication number: 20240279187
    Abstract: The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.
    Type: Application
    Filed: December 5, 2023
    Publication date: August 22, 2024
    Inventors: Omid Veiseh, Richard Heidebrecht, Paul Kevin Wotton, Matthias Alexander Oberli, Robert James Miller
  • Publication number: 20240241167
    Abstract: An irrigation system comprises a plurality of towers, a time domain reflectometry (TDR) unit, and a central controller. Each tower includes a successive one of a plurality of safety switches, with each safety switch being either closed or open. The safety switch of each tower is electrically connected to at least one safety switch of another tower. The TDR unit is electrically connected to at least one safety switch and is configured to output data regarding an open safety switch. The central controller is configured to receive data from the TDR unit, and determine, according to the data from the TDR unit, at least one of a location of the open safety switch and an identifier of the tower associated with the open safety switch.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 18, 2024
    Inventors: Derick James Frauendorfer, Bradford L. Ellison, Robert Stamm, Luke Joseph Barker, Mark William Miller, Steve Aikman
  • Patent number: 11945786
    Abstract: The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: April 2, 2024
    Assignee: SIGILON THERAPEUTICS, INC.
    Inventors: Omid Veiseh, Richard Heidebrecht, Paul Kevin Wotton, Matthias Alexander Oberli, Robert James Miller
  • Patent number: 11858219
    Abstract: Adhesive bondlines in a cell-based structural array are thermally cured using tooling blocks inserted into the cells. The tooling blocks have embedded susceptors that are inductively heated by an alternating electromagnetic field generated by an electromagnet.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: January 2, 2024
    Assignee: THE BOEING COMPANY
    Inventors: Joseph Lawrence Hafenrichter, Joseph A. Marshall, Gary Earnest Georgeson, David L. Banks, Robert James Miller, Paul B Mori
  • Publication number: 20230123802
    Abstract: Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.
    Type: Application
    Filed: March 27, 2020
    Publication date: April 20, 2023
    Inventors: Lauren Emily Barney, Michael Beauregard, Guillaume Carmona, Francisco Caballero Gonzalez, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller, Owen O'Connor, Matthias Alexander Oberli, David Peritt, Jared A. Sewell, Devyn McKinley Smith, Omid Veiseh, Paul Kevin Wotton, Zoe Yin
  • Publication number: 20230008121
    Abstract: Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 12, 2023
    Inventors: Michael Beauregard, Faith C. David-Hegerich, John Patrick Golden, Joseph Gordon, Erika Ellen Johnston, Robert James Miller, Justin David Morse, Peter Calvin Costello
  • Publication number: 20220267794
    Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.
    Type: Application
    Filed: March 27, 2020
    Publication date: August 25, 2022
    Inventors: Lauren Emily Barney, Michael Beauregard, Guillaume Carmona, Francisco Caballero Gonzalez, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller, Owen O'Connor, Matthias Alexander Oberli, David Peritt, Jared A. Sewell, Devyn McKinley Smith, Omid Veiseh, Jeffrey Charles Way, Paul Kevin Wotton, Zoe Yin, Elina Makino, Brian Richard Fluharty, Marianthi Papakosta
  • Publication number: 20220072803
    Abstract: Adhesive bondlines in a cell-based structural array are thermally cured using tooling blocks inserted into the cells. The tooling blocks have embedded susceptors that are inductively heated by an alternating electromagnetic field generated by an electromagnet.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 10, 2022
    Inventors: Joseph Lawrence Hafenrichter, Joseph A. Marshall, Gary Earnest Georgeson, David L. Banks, Robert James Miller, Paul B. Mori
  • Patent number: 11272582
    Abstract: A coaxially arranged smart susceptor conductor, comprising a smart susceptor core comprising an alloy having a first Curie temperature point and a first smart susceptor shell coaxially arranged around the smart susceptor core. The first smart susceptor shell comprising a second Curie temperature point that is different than the first Curie temperature point of the smart susceptor core. In one arrangement, the second Curie temperature point of the first smart susceptor shell is lower than the first Curie temperature point of the smart susceptor core. In another arrangement, the smart susceptor conductor further comprises a second smart susceptor shell disposed about the first smart susceptor shell. The second smart susceptor shell comprising a third Curie temperature point.
    Type: Grant
    Filed: October 19, 2019
    Date of Patent: March 8, 2022
    Assignee: The Boeing Company
    Inventors: Robert James Miller, Marc Rollo Matsen, Cameron Kai-Ming Chen, Leah Gillian Glauber, James M. Kestner, Christopher John Hottes
  • Publication number: 20220000789
    Abstract: Described herein are implantable devices comprising means for mitigating the foreign body response (FBR) and at least one cell-containing compartment which comprises a plurality of cells (e.g., live cells) encapsulated in a polymer composition comprising a cell-binding substance (CBS), as well as compositions and methods of making and using the same. The cells are capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 6, 2022
    Inventors: Lauren Emily Barney, Michael Beauregard, Guillaume Carmona, Francisco Caballero Gonzalez, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller, Owen O'Connor, Matthias Alexander Oberli, David Peritt, Jared A. Sewell, Devyn McKinley Smith, Omid Veiseh, Paul Kevin Wotton, Zoe Yin
  • Patent number: 11186046
    Abstract: Adhesive bondlines in a cell-based structural array are thermally cured using tooling blocks inserted into the cells. The tooling blocks have embedded susceptors that are inductively heated by an alternating electromagnetic field generated by an electromagnet.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 30, 2021
    Assignee: The Boeing Company
    Inventors: Joseph Lawrence Hafenrichter, Joseph A. Marshall, Gary Earnest Georgeson, David L. Banks, Robert James Miller, Paul B. Mori
  • Publication number: 20210145889
    Abstract: Described herein are cell compositions comprising a mesenchymal stem function cell (MSFC), e.g., an engineered MSFC or derivatives thereof, as well as compositions, pharmaceutical products, and implantable elements comprising an MSFC, and methods of making and using the same. The cells and compositions may express a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
    Type: Application
    Filed: March 27, 2019
    Publication date: May 20, 2021
    Inventors: Devyn McKinley Smith, David Peritt, Omid Veiseh, Richard Heidebrecht, Robert James Miller
  • Publication number: 20210145759
    Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.
    Type: Application
    Filed: March 27, 2019
    Publication date: May 20, 2021
    Inventors: Lauren Emily Barney, Michael Beauregard, Guillaume Carmona, Francisco Caballero Gonzalez, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller, Matthias Alexander Oberli, Owen O'Connor, David Peritt, Jared A. Sewell, Devyn McKinley Smith, Omid Veiseh, Paul Kevin Wotton
  • Publication number: 20210060205
    Abstract: Described herein are compounds of Formula (I), modified polymers and implantable elements comprising compounds of Formula (II), as well as compositions and methods of use thereof. In particular, the compounds, modified polymers, implantable elements and related compositions may be used in methods for the prevention and treatment of a disease, disorder or condition in a subject.
    Type: Application
    Filed: March 1, 2019
    Publication date: March 4, 2021
    Inventors: Richard Heidebrecht, Robert James Miller, Omid Veiseh
  • Publication number: 20210002433
    Abstract: Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules.
    Type: Application
    Filed: March 1, 2019
    Publication date: January 7, 2021
    Inventors: Lauren Emily Barney, Richard Heidebrecht, Erika Ellen Johnston, Robert James Miller