Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: Techniques are described for debugging node devices. A node device may be connected to a host device for debugging purposes. A debugger, providing debug functionality, such as a debugging web application, may run on a remote server and be accessed via a web browser running at the host device, to debug the node device. Alternatively, the debugging web application may execute in the web browser running at the host device to debug the node device. In another alternative, the debugging web application may execute at a gateway device provided between the node device and the host device. In all cases the debugging web application is controlled via a debug user interface running at the web browser. Consequently, a user of the host device is not required to install a debugger at the host device in order to debug a node device.

Abstract: Techniques are described for debugging node devices. A node device may be connected to a host device for debugging purposes. A debugger, providing debug functionality, such as a debugging web application, may run on a remote server and be accessed via a web browser running at the host device, to debug the node device. Alternatively, the debugging web application may execute in the web browser running at the host device to debug the node device. In another alternative, the debugging web application may execute at a gateway device provided between the node device and the host device. In all cases the debugging web application is controlled via a debug user interface running at the web browser. Consequently, a user of the host device is not required to install a debugger at the host device in order to debug a node device.

Abstract: An electronic device is provided for managing assignment of peripheral devices in a virtualization environment. The electronic device can include a user interface configured to display one or more representations of virtual desktops. The virtual desktops are associated with corresponding virtual machines. The electronic devices can also include one or more processors configured to provide to the user interface to display one or more representations of the peripheral devices based on detection that the peripheral devices are communicatively coupled to a control virtual machine of the virtualization environment. The one or more processors can be further configured to detect one or more first inputs received with respect to the one or more representations of the virtual desktops and the one or more representations of the peripheral devices; and facilitate to establish one or more associations between the peripheral devices and the virtual machines.

Abstract: An electronic device is provided for managing assignment of peripheral devices in a virtualization environment. The electronic device can include a user interface configured to display one or more representations of virtual desktops. The virtual desktops are associated with corresponding virtual machines. The electronic devices can also include one or more processors configured to provide to the user interface to display one or more representations of the peripheral devices based on detection that the peripheral devices are communicatively coupled to a control virtual machine of the virtualization environment. The one or more processors can be further configured to detect one or more first inputs received with respect to the one or more representations of the virtual desktops and the one or more representations of the peripheral devices; and facilitate to establish one or more associations between the peripheral devices and the virtual machines.

Abstract: An exhaust gas recirculation valve (10) for installation between an air intake (12) and an exhaust of an engine comprising a housing (18) having a first (20), second (22), and third (24) sides, a first bore (26) opening through the first side for connection with the air intake, a second bore (28) opening through the second side for receiving exhaust gas from the exhaust, a third bore (30) opening through the first side for connection with the air intake, and a fourth bore (32) opening through the third side and passing in succession through the first bore, the second bore and the third bore; a valve stem (34) positioned in the fourth bore and extending out of the third side of the housing; a valve seat (36) in the fourth bore at the opening (38) of the second bore to the third bore; an annular seal (40) mounted in the fourth bore at the opening (42) of the first bore to the second bore; a valve head (44) on the valve stem within the second bore and normally in engagement with the valve seat; a sleeve (46) mou

Abstract: An exhaust gas recirculation valve (10) for installation between an air intake and an exhaust of an engine comprising a housing (12) having a first bore (14) for connection with the air intake and a second bore (16) for receiving exhaust gas from the exhaust, the second bore being at an angle to the first bore and opening into the first bore; a valve stem (24) extending from the first bore into the second bore; a valve seat (28) in the second bore at the opening (18) of the second bore into the first bore; a valve head (30) on the valve stem within the second bore and normally in engagement with the valve seat; eccentric drive means (42) rotatably mounted in the first bore and connected to the valve stem; actuating means (34) mounted on the housing and connected to the eccentric drive means, which, on actuation, rotates the eccentric drive means to move the valve stem to disengage the valve head from the valve seat. EGR valve suitable for a diesel engine or other types of engine.