Patents by Inventor Robert James Pearce

Robert James Pearce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acid derivatives
    Patent number: 5981531
    Abstract: The invention concerns acid derivatives of formula IR.sup.1 --CON(R.sup.2)--N(R.sup.3)CO--X.sup.1 --Q--X.sup.2 --Gand pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, X.sup.1, Q, X.sup.2 and G have the meanings given in the specification. The invention also concerns processes for the preparation of the acid derivatives of formula I, pharmaceutical compositions containing them and their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: November 9, 1999
    Assignee: Zeneca Limited
    Inventors: Andrew George Brewster, Peter William Rodney Caulkett, Alan Wellington Faull, Robert James Pearce, Richard Eden Shute
  • Certain?(piperidin-4-yl-alkanoyl)carbazoyl!-carboxy-phenoxy derivatives
    Patent number: 5760057
    Abstract: The invention concerns acid derivatives of formula IR.sup.1 --CON(R.sup.2)--N(R.sup.3)CO--X.sup.1 --Q--X.sup.2 --G(I)and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, X.sup.1, Q, X.sup.2 and G have the meanings given in the specification. The invention also concerns processes for the preparation of the acid derivatives of formula I, pharmaceutical compositions containing them their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: June 2, 1998
    Assignee: Zeneca Limited
    Inventors: Andrew George Brewster, Peter William Rodney Caulkett, Alan Wellington Faull, Robert James Pearce, Richard Eden Shute
  • Heterocyclic derivatives
    Patent number: 5728701
    Abstract: Compounds of formula I ##STR1## and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.13, M.sup.2, X.sup.1, Z.sup.1, Z.sup.1a, X.sup.2 and A.sup.1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Novel intermediates are also disclosed.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: March 17, 1998
    Assignee: Zeneca Limited
    Inventors: Michael Garth Wayne, Michael James Smithers, John Wall Rayner, Alan Wellington Faull, Robert James Pearce, Andrew George Brewster, Richard Eden Shute, Stuart Dennett Mills, Peter William Rodney Caulkett
  • Heterocyclic derivatives
    Patent number: 5652242
    Abstract: Compounds of formula I ##STR1## and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.13, M.sup.2, X.sup.1, Z.sup.1, Z.sup.1a, X.sup.2 and A.sup.1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Novel intermediates are also disclosed.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 29, 1997
    Assignee: Zeneca Limited
    Inventors: Michael Garth Wayne, Michael James Smithers, John Wall Rayner, Alan Wellington Faull, Robert James Pearce, Andrew George Brewster, Richard Eden Shute, Stuart Dennett Mills, Peter William Rodney Caulkett
  • 1'-Substituted xanthene-9-spiro-4'-piperidine derivatives
    Patent number: 4001419
    Abstract: The disclosure relates to xanthene derivatives which possess analgesic activity, to processes for the manufacture of said derivatives and to pharmaceutical compositions containing them. Typical of the xanthene derivatives disclosed is 6-chloro-4-hydroxy-1'-methylxanthene-9-spiro-4'-piperidine.
    Type: Grant
    Filed: January 9, 1975
    Date of Patent: January 4, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventors: Ronald Hilson Begg Galt, Robert James Pearce