Abstract: Energy is transmitted to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: There is described a process for producing at least one of mycoprotein and the components thereof, the process comprising: (i) providing a fermentation media suitable for producing mycoprotein; (ii) fermenting the fermentation media to obtain a mixture comprising mycoprotein; (iii) separating the mycoprotein from the mixture to obtain a mycoprotein phase; and (iv) mechanically disrupting the cell walls of the mycoprotein in the mycoprotein phase thereby releasing at least some of the mycoprotein cell contents. There is also described at least one of mycoprotein and the components thereof obtainable, obtained or directly obtained from the process. Further described is a composition comprising at least one of mycoprotein and the components thereof, wherein the composition is non-fibrous. The composition may comprise at least one of: protein obtained from mycoprotein, and amino acids derived from protein obtained from mycoprotein.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device, The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device. The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: A facility readiness inspection system and method are disclosed. Embodiments comprise an asset database comprising inspection task definition for assets. An inspection coordination application program interface (API) can create at least one periodic inspection task list. Each periodic inspection task list can include a number of tasks and assets, chosen based on the total time allotted for completion of the periodic inspection task list and the complexity of the inspection task definitions of each physical asset. Mobile electronic device can be configured to present the periodic inspection task list as a series of discrete tasks and to receive task list response data in response to each discrete task. Response data can be compared to benchmarks and standards, and issues can be escalated to external systems. An analytics engine can automatically produce inspection compliance documentation for each of the physical assets related to the periodic inspection task list.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: A facility readiness inspection system and method are disclosed. Embodiments comprise an asset database comprising inspection task definition for assets. An inspection coordination application program interface (API) can create at least one periodic inspection task list. Each periodic inspection task list can include a number of tasks and assets, chosen based on the total time allotted for completion of the periodic inspection task list and the complexity of the inspection task definitions of each physical asset. Mobile electronic device can be configured to present the periodic inspection task list as a series of discrete tasks and to receive task list response data in response to each discrete task. Response data can be compared to benchmarks and standards, and issues can be escalated to external systems. An analytics engine can automatically produce inspection compliance documentation for each of the physical assets related to the periodic inspection task list.

Abstract: There is described a continuous process for producing and isolating mycoprotein. The process may comprise the steps of: providing a fermentation media suitable for producing mycoprotein; introducing the fermentation media to a first fermentation vessel; fermenting the fermentation media to obtain a mixture comprising mycoprotein and partially spent fermentation media; isolating at least part of the partially spent fermentation media from the mixture comprising mycoprotein and partially spent fermentation media; and reintroducing at least a portion of the isolated partially spent fermentation media into the first fermentation vessel. Also described is mycoprotein obtained from the process.

Abstract: Shipment receiving systems and methods are disclosed. Invoice and store inventory management data is provided to an invoice processor for assigning expected destinations to lanes of a material transporter having and a plurality of outlet lanes that each have an indicator. A scanner determines a case identifier for each case which is routed accordingly. One or more notifications is provided to the indicator of one or more of the plurality of outlet lanes. Received shipment data enables reconciliation of upstream supply change management systems and downstream store inventory systems.

Abstract: A method is for providing a uniform resource locator. In an embodiment, the method includes receiving a medical data record via an interface, the medical data record being related to a patient; determining the uniform resource locater related to the medical data record via a computation unit, the uniform resource locator including an authorization token based on the medical data record, the medical data record being accessible by following the uniform resource locator; and providing the uniform resource locator with the interface to the patient. By providing a uniform resource locator of an embodiment including an authorization token, access to the medical data record can be granted fast and efficient, e.g. by a patient forwarding the uniform resource locator to another entity (e.g. a physician), while at the same time non-authorized entities cannot access the medical data record due to their lack of the suitable authorization token.

Abstract: A “smart ” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.

Abstract: A “smart” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: A technique for monitoring the quality of objects is disclosed. A container includes a multiple sensors and is configured to receive an object. The sensors monitor various metrics associated with the quality of the object, and a display is affixed to the container for displaying a visual indication of the quality of the object. The visual indication is based on data collected from the sensors. A quality monitoring module is executed by a processor to control the sensors to switch operation between a first mode of operation and a second mode of operation based on a detected change in one of the metrics monitored by the sensors.

Abstract: Exploiting FPGAs for acceleration may be performed by transforming concurrent programs. One example method of operation may provide creating synchronous hardware accelerators from concurrent asynchronous programs at software level, by obtaining input as software instructions describing concurrent behavior via a model of communicating sequential processes (CSP) of message exchange between concurrent processes performed via channels, mapping, on a computing device, each of the concurrent processes to synchronous dataflow primitives, comprising at least one of join, fork, merge, steer, variable, and arbiter, producing a clocked digital logic description for upload to one or more field programmable gate array (FPGA) devices, performing primitive remapping of the output design for throughput, clock rate and resource usage via retiming, and creating an annotated graph of the input software description for debugging of concurrent code for the field FPGA devices.

Abstract: Shipment receiving systems and methods are disclosed. Invoice and store inventory management data is provided to an invoice processor for assigning expected destinations to lanes of a material transporter having and a plurality of outlet lanes that each have an indicator. A scanner determines a case identifier for each case which is routed accordingly. One or more notifications is provided to the indicator of one or more of the plurality of outlet lanes. Received shipment data enables reconciliation of upstream supply change management systems and downstream store inventory systems.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.