Abstract: Disclosed herein are continuous flow systems having bifurcated fluidic flow mixers. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). DVBMs utilize Dean vortexing and bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device, The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: A facility readiness inspection system and method are disclosed. Embodiments comprise an asset database comprising inspection task definition for assets. An inspection coordination application program interface (API) can create at least one periodic inspection task list. Each periodic inspection task list can include a number of tasks and assets, chosen based on the total time allotted for completion of the periodic inspection task list and the complexity of the inspection task definitions of each physical asset. Mobile electronic device can be configured to present the periodic inspection task list as a series of discrete tasks and to receive task list response data in response to each discrete task. Response data can be compared to benchmarks and standards, and issues can be escalated to external systems. An analytics engine can automatically produce inspection compliance documentation for each of the physical assets related to the periodic inspection task list.

Abstract: A technique for monitoring objects in a cart is disclosed. A cart is configured to receive an object and includes a plurality of sensors configured to detect a location of the cart and a characteristic of an object in the cart. The cart also includes a docking station that can receive an electronic device and operatively and electrically couple the sensors to the electronic device. A computing system is in communication with the electronic device and configured to access a database containing a stored list generated by the user. The computing can identify the object in the cart based, at least in part, on data received from the plurality of sensors and the location of the cart. The computing system can also determine whether the object in the cart is included on the stored list.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: A method is for providing a uniform resource locator. In an embodiment, the method includes receiving a medical data record via an interface, the medical data record being related to a patient; determining the uniform resource locater related to the medical data record via a computation unit, the uniform resource locator including an authorization token based on the medical data record, the medical data record being accessible by following the uniform resource locator; and providing the uniform resource locator with the interface to the patient. By providing a uniform resource locator of an embodiment including an authorization token, access to the medical data record can be granted fast and efficient, e.g. by a patient forwarding the uniform resource locator to another entity (e.g. a physician), while at the same time non-authorized entities cannot access the medical data record due to their lack of the suitable authorization token.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: Shipment receiving systems and methods are disclosed. Invoice and store inventory management data is provided to an invoice processor for assigning expected destinations to lanes of a material transporter having and a plurality of outlet lanes that each have an indicator. A scanner determines a case identifier for each case which is routed accordingly. One or more notifications is provided to the indicator of one or more of the plurality of outlet lanes. Received shipment data enables reconciliation of upstream supply change management systems and downstream store inventory systems.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device, The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device. The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: A facility readiness inspection system and method are disclosed. Embodiments comprise an asset database comprising inspection task definition for assets. An inspection coordination application program interface (API) can create at least one periodic inspection task list. Each periodic inspection task list can include a number of tasks and assets, chosen based on the total time allotted for completion of the periodic inspection task list and the complexity of the inspection task definitions of each physical asset. Mobile electronic device can be configured to present the periodic inspection task list as a series of discrete tasks and to receive task list response data in response to each discrete task. Response data can be compared to benchmarks and standards, and issues can be escalated to external systems. An analytics engine can automatically produce inspection compliance documentation for each of the physical assets related to the periodic inspection task list.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: A facility readiness inspection system and method are disclosed. Embodiments comprise an asset database comprising inspection task definition for assets. An inspection coordination application program interface (API) can create at least one periodic inspection task list. Each periodic inspection task list can include a number of tasks and assets, chosen based on the total time allotted for completion of the periodic inspection task list and the complexity of the inspection task definitions of each physical asset. Mobile electronic device can be configured to present the periodic inspection task list as a series of discrete tasks and to receive task list response data in response to each discrete task. Response data can be compared to benchmarks and standards, and issues can be escalated to external systems. An analytics engine can automatically produce inspection compliance documentation for each of the physical assets related to the periodic inspection task list.

Abstract: Shipment receiving systems and methods are disclosed. Invoice and store inventory management data is provided to an invoice processor for assigning expected destinations to lanes of a material transporter having and a plurality of outlet lanes that each have an indicator. A scanner determines a case identifier for each case which is routed accordingly. One or more notifications is provided to the indicator of one or more of the plurality of outlet lanes. Received shipment data enables reconciliation of upstream supply change management systems and downstream store inventory systems.

Abstract: A method is for providing a uniform resource locator. In an embodiment, the method includes receiving a medical data record via an interface, the medical data record being related to a patient; determining the uniform resource locater related to the medical data record via a computation unit, the uniform resource locator including an authorization token based on the medical data record, the medical data record being accessible by following the uniform resource locator; and providing the uniform resource locator with the interface to the patient. By providing a uniform resource locator of an embodiment including an authorization token, access to the medical data record can be granted fast and efficient, e.g. by a patient forwarding the uniform resource locator to another entity (e.g. a physician), while at the same time non-authorized entities cannot access the medical data record due to their lack of the suitable authorization token.

Abstract: A “smart ” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.