Patents by Inventor Robert James Weikert

Robert James Weikert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF OPHTHALMOLOGIC DISEASES
    Publication number: 20230416353
    Abstract: The current invention relates to the use of antibodies which bind to VEGF and ANG2 for the treatment of ophthalmologic diseases.
    Type: Application
    Filed: February 9, 2023
    Publication date: December 28, 2023
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Aaron Osborne, Jayashree Sahni, Robert James Weikert
  • PERSONALIZED TREATMENT OF OPHTHALMOLOGIC DISEASES
    Publication number: 20220162296
    Abstract: The current invention relates to antibodies which bind to VEGF and ANG2 for use in the treatment of ocular vascular diseases such as neovascular AMD (nAMD) (also known as choroidal neovascularization [CNV] secondary to age-related macular degeneration [AMD] or wet AMD), diabetic retinopathy in particular diabetic macular edema (DME) or macular edema secondary to retinal vein occlusion (RVO).
    Type: Application
    Filed: February 4, 2022
    Publication date: May 26, 2022
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Hugh Lin, Aaron Osborne, David Andrew Silverman, Robert James Weikert, Jeffery R. Willis
  • TREATMENT OF OPHTHALMOLOGIC DISEASES
    Publication number: 20210139576
    Abstract: The current invention relates to the use of antibodies which bind to VEGF and ANG2 for the treatment of ophthalmologic diseases.
    Type: Application
    Filed: August 5, 2020
    Publication date: May 13, 2021
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Aaron Osborne, Jayashree Sahni, Robert James Weikert
  • Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9949966
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: April 24, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • Antiviral compounds
    Patent number: 9896433
    Abstract: The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: February 20, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Zhi Chen, Elbert Chin, Shawn David Erickson, Stephen Deems Gabriel, Eric Mertz, Robert James Weikert
  • Inhibitors of bruton's tyrosine kinase
    Patent number: 9617260
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: April 11, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Elbert Chin, Robert James Weikert, Weiya Yun, Jing Zhang
  • Antiviral compounds
    Patent number: 9511059
    Abstract: The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: December 6, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Joseph Anthony Bilotta, Zhi Chen, Qingjie Ding, Shawn David Erickson, Eric Mertz, Robert James Weikert
  • NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160296515
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 21, 2016
    Publication date: October 13, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9458153
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: October 4, 2016
    Assignee: Hoffmann-La Roche INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20160280706
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: March 31, 2014
    Publication date: September 29, 2016
    Inventors: Elbert Chin, Robert James Weikert, Weiya Yun, Jing Zhang
  • Antiviral compounds
    Patent number: 9428469
    Abstract: The present invention discloses compounds of Formula (I): wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: August 30, 2016
    Assignee: HOFFMANN-LA ROCHE
    Inventors: Qingjie Ding, Nan Jiang, Robert James Weikert
  • Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20160207914
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 30, 2015
    Publication date: July 21, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • N-heteroaryl substituted aniline derivatives as HCV-antivirals
    Patent number: 9382218
    Abstract: The present invention discloses compounds of Formula (I): wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: July 5, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Marc Plancher, Robert James Weikert
  • ANTIVIRAL COMPOUNDS
    Publication number: 20160009666
    Abstract: The present invention discloses compounds of Formula (I): wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 14, 2016
    Inventors: Qingjie Ding, Nan Jiang, Robert James Weikert
  • N-HETEROARYL SUBSTITUTED ANILINE DERIVATIVES AS HCV-ANTIVIRALS
    Publication number: 20160000763
    Abstract: The present invention discloses compounds of Formula (I): wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Inventors: Jean-Marc Plancher, Robert James Weikert
  • ANTIVIRAL COMPOUNDS
    Publication number: 20150376165
    Abstract: The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Application
    Filed: March 3, 2014
    Publication date: December 31, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhi Chen, Elbert Chin, Shawn David Erickson, Stephen Deems Gabriel, Eric Mertz, Robert James Weikert
  • ANTIVIRAL COMPOUNDS
    Publication number: 20150353511
    Abstract: The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 10, 2015
    Inventors: Joseph Anthony Bilotta, Zhi Chen, Qingjie Ding, Shawn David Erickson, Eric Mertz, Robert James Weikert
  • Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150210682
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 30, 2015
    Publication date: July 30, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • ANTIVIRAL COMPOUNDS
    Publication number: 20140242028
    Abstract: The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
    Type: Application
    Filed: January 21, 2014
    Publication date: August 28, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joseph Anthony Bilotta, Zhi Chen, Qingjie Ding, Shawn David Erickson, Eric Mertz, Robert James Weikert
  • Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
    Patent number: 8513425
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: August 20, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Pravin Iyer, Clara Jeou Jen Lin, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Kerem Erol Ozboya, Robert James Weikert, Ryan Craig Schoenfeld