Abstract: The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a polypeptide (e.g., a therapeutic polypeptide). Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness.

Abstract: The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a clarin 1 protein. Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness. Also provided are methods of using disclosed constructs for the treatment of vision loss.

Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

Abstract: A system and method is provided for generating a display, including information from disparate data sources, for presentation on a device. This display takes a user entry in a personal productivity application and augments the data with data gleaned from a variety of additional sources, including local and external datasets. The system first receives a set of ‘values’ and a set of ‘keywords’. The values and keywords may be generated by parsing a user created entry in a personal productivity application. The criteria for what constitutes keywords and values may be configured by the user. The ‘values’ identified are functionally related to the ‘keywords’. This functional relationship is then analyzed in order to generate the types of data to be displayed. Then a search of disparate data sources is performed to compile the needed data. Once all the data is collected it may be aggregated into a single dataset for display on the device.