Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract: A system and method for review and analysis of electrocardiograms includes an application server computer system in communication with a plurality of client computers. In a preferred embodiment, the server computer provides notification and access of a patient cardiac study report to an electrocardiograph technician for review and comment. The technician assigns an academic fellow electrophysiologist to review the study report. The server computer provides notification and access of the study report and the technician's annotation to the assigned fellow for review and comment. The fellow then assigns an attending physician to review the study report. The server computer provides notification and access of the study report and the previous annotations to the attending physician for review and comment. The physician completes the study. The computer system automatically generates and forwards a referral letter to the requesting physician and attends to billing for the cardiac monitoring services.

Abstract: The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG breakdown products retaining antigen binding but having lost effector functions.

Abstract: The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies.

Abstract: A package and lock combination includes a package having an unopened state and including an aperture, and a lock contained within the package. The lock includes a first portion and a second portion moveable relative to the first portion for operating the lock. The first portion is substantially fixed within the package, and the second portion extends through the aperture so that the lock is operable while the lock is contained within the package and the package is in the unopened state.

Abstract: Disclosed is an underwater lighting apparatus securable in the transom drain hole of a vessel. The apparatus is formed from a support structure having a chamber for housing at least LED. An outer surface of the support structure is sized and arranged to sealingly secure to the transom drain hole of a conventional boat to prevent water passage. The apparatus includes electrical connections extending through the end of the support structure for coupling to a power source. Illumination behind the boat is provided by an LED, halogen or other high intensity lighting source.

Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.

Abstract: An insert for receiving a bone screw includes an elongate sleeve having opposed proximal and distal ends and a wall defined by an outer peripheral surface configured for engaging bone and an inner peripheral surface configured for receiving a bone screw extended therethrough. At least one elongate slot is formed in the wall of the sleeve for promoting flexure of the insert. A tool for affixing an orthopedic screw insert within bone tissue includes a socket portion configured and adapted to engage a proximal section of an outer peripheral surface of an orthopedic screw insert. A driver extends distally from the socket portion. The driver is configured and adapted to engage a section of an inner peripheral surface of the orthopedic screw insert distal from the socket portion.

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract: The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies.

Abstract: Transgenic mice expressing human tissue factor which are useful for evaluating pharmacologic agents which interact with human tissue factor and for investigating diseases associated with human tissue factor.

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract: A combination prepared food container and eating tray comprising a bottom panel, a rear panel extending from the bottom panel, a first opposing side panel extending from the bottom panel, a second opposing side panel extending from the bottom panel, a hinged closable top panel extending from the rear panel, and a hinged closable front panel with rim on three sides extending from the bottom panel and providing the eating tray area, all panels suitably dimensioned to accommodate typical prepared meals.

Abstract: One or more pluggable install components may be used with a modular install configuration engine. Each install component carries instructions that allow an install components to be used with the configuration engine. Each install component also carries payload files for deployment onto a user's end system. Each install component may be created and updated by a plurality of vendors or programming groups. Upon installation, the install component and the modular install configuration engine are integrated to create a unique install program tailored to the needs of a particular customer.

Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.