Patent number: 4659727
Abstract: Ethene derivatives of the formula:[R.sup.5 (R.sup.1 CR.sup.4 .dbd.CR.sup.2 R.sup.3).sub.m ].sub.n Iwherein R.sup.5 represents optionally substituted heterocyclyl or a group --CR.sup.4 .dbd.CR.sup.2 R.sup.3, or optionally substituted aryl, heterocyclylalkyl or arylalkyl and R.sup.1 represents --NR.sup.6 -- wherein R.sup.6 represents hydrogen or optionally substituted alkyl or aryl, or R.sup.5 represents a quinonoidal group, and R.sup.1 represents .dbd.N--, R.sup.4 represents hydrogen, alkoxy, alkylthio, trifluoromethyl or optionally substituted alkyl or aryl, R.sup.2 represents cyano, formyl, alkoxycarbonyl, alkylsulphonyl, dialkylcarbamoyl, dialkylthiocarbamoyl, aryloxycarbonyl, arylsulphinyl or arylsulphonyl, R.sup.3 represents a group R.sup.2 or hydrogen, nitro or optionally substituted aryl or aroyl or alkanoyl, and m and n are 1 or 2, and pharmaceutically acceptable salts thereof, with the exclusion of certain compounds in which R.sup.
Type:
Grant
Filed:
September 10, 1985
Date of Patent:
April 21, 1987
Assignee:
May & Baker Limited
Inventors:
Adnan H. Al-Shaar, Barbara J. Broughton, Robert K. Chambers, David W. Gilmour, Diane M. Kelsey, Peter Lowden, Edward Lunt, David J. Lythgoe, Ian McClenaghan, Duncan C. McDougall, Libert C. Saunders, Keith A. J. Stuttle, Peter J. Warne