Patents by Inventor Robert K. Hickman

Robert K. Hickman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180230210
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: April 6, 2018
    Publication date: August 16, 2018
    Applicant: AbbVie Inc.
    Inventor: Robert K. Hickman
  • Patent number: 9975948
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: May 22, 2018
    Assignee: Abbvie, Inc.
    Inventor: Robert K. Hickman
  • Publication number: 20170158760
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: February 3, 2017
    Publication date: June 8, 2017
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Publication number: 20160272673
    Abstract: Chromatographic methods for isolating and purifying DVD-lgs™ from a sample, wherein the purified DVD-lgs™ have reduced host cell proteins, aggregates, and viruses compared to the sample.
    Type: Application
    Filed: November 7, 2014
    Publication date: September 22, 2016
    Inventors: Heidi Althouse, Shilpa Ananthakrishnan, Germano Coppola, Scott T. Ennis, Robert K. Hickman, Chen Wang, Joe Yakamavich
  • Publication number: 20160272674
    Abstract: Embodiments of the present invention are directed to high throughput flow through purification of antibodies using mixed mode chromatography.
    Type: Application
    Filed: November 7, 2014
    Publication date: September 22, 2016
    Inventors: Heidi Althouse, Shilpa Ananthakrishnan, Germano Coppola, Scott T. Ennis, Robert K. Hickman, Chen Wang, Joe Yakamavich
  • Publication number: 20160130339
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 12, 2016
    Inventor: Robert K. HICKMAN
  • Publication number: 20160083452
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: April 27, 2015
    Publication date: March 24, 2016
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Patent number: 9266950
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: February 23, 2016
    Assignee: AbbVie Inc.
    Inventor: Robert K. Hickman
  • Publication number: 20150344564
    Abstract: Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 3, 2015
    Inventors: Robert K. Hickman, Ivan R. Correia
  • Patent number: 9109010
    Abstract: Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: August 18, 2015
    Assignee: AbbVie Inc.
    Inventors: Robert K. Hickman, Ivan R. Correia
  • Publication number: 20150210735
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: April 13, 2015
    Publication date: July 30, 2015
    Applicant: AbbVie Inc.
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Patent number: 9018361
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: April 28, 2015
    Assignee: AbbVie Inc.
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Publication number: 20150065696
    Abstract: The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column.
    Type: Application
    Filed: June 4, 2014
    Publication date: March 5, 2015
    Inventors: Chen Wang, Robert K. Hickman, I, Edwin O. Lundell, Roy D. Hegedus
  • Patent number: 8895709
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: November 25, 2014
    Assignee: AbbVie Inc.
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Publication number: 20140255423
    Abstract: Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Application
    Filed: March 26, 2014
    Publication date: September 11, 2014
    Applicant: AbbVie Inc.
    Inventors: Robert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
  • Patent number: 8785596
    Abstract: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: July 22, 2014
    Assignee: Abbott Laboratories
    Inventors: John R. Hackett, Jr., Julie Yamaguchi, Alan M. Golden, Catherine A. Brennan, Robert K. Hickman, Sushil G. Devare
  • Publication number: 20130195888
    Abstract: Disclosed herein are methods of purifying proteins using ultrafiltration and diafiltration processes.
    Type: Application
    Filed: March 12, 2013
    Publication date: August 1, 2013
    Applicant: AbbVie
    Inventors: Chen WANG, Germano COPPOLA, Johanna GERVAIS, Robert K. HICKMAN, Roy D. HEGEDUS, Gregory J. BUNK
  • Patent number: 8491904
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: July 23, 2013
    Assignee: Abbvie Inc.
    Inventor: Robert K. Hickman
  • Publication number: 20120264920
    Abstract: The invention is directed to a method for purifying a protein. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, inactivating viruses in the sample, and processing through at least one depth filter and ion-exchange membrane.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 18, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Chen Wang, Robert K. Hickman
  • Publication number: 20110301342
    Abstract: The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column.
    Type: Application
    Filed: April 13, 2011
    Publication date: December 8, 2011
    Applicant: ABBOTT LABORATORIES, INC.
    Inventors: Chen Wang, Robert K. Hickman, Edwin O. Lundell, Roy D. Hegedus