Patents by Inventor Robert Kain
Robert Kain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9816929Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: September 18, 2014Date of Patent: November 14, 2017Assignee: ILLUMINA, INC.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Publication number: 20150069267Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: ApplicationFiled: September 18, 2014Publication date: March 12, 2015Applicant: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 8884211Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: March 12, 2012Date of Patent: November 11, 2014Assignee: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 8753584Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.Type: GrantFiled: November 20, 2013Date of Patent: June 17, 2014Assignees: Illumina, Inc., The Arizona Board of Regents for and on behalf of Arizona State UniveristyInventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain, Michael Schroeder
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Publication number: 20140080205Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.Type: ApplicationFiled: November 20, 2013Publication date: March 20, 2014Applicants: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY, ILLUMINA, INC.Inventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain, Michael Schroeder
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Patent number: 8597594Abstract: An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.Type: GrantFiled: July 18, 2012Date of Patent: December 3, 2013Assignee: Illumina, Inc.Inventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain, Michael Schroeder
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Publication number: 20120292190Abstract: An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.Type: ApplicationFiled: July 18, 2012Publication date: November 22, 2012Applicants: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY, ILLUMINA, INC.Inventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain
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Patent number: 8252250Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.Type: GrantFiled: November 25, 2009Date of Patent: August 28, 2012Assignees: Illumina, Inc., The Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain
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Publication number: 20120168644Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: ApplicationFiled: March 12, 2012Publication date: July 5, 2012Applicant: ILLUMINA, INC.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 8158926Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: May 2, 2011Date of Patent: April 17, 2012Assignee: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 8023162Abstract: A scanning technique for imaging sites in an array includes illuminating or irradiating sites in lines of the array, and collecting returned radiation from the sites for imaging. The sites are sequentially scanned by means of confocally directed radiation lines from source optics. The orientation of the radiation lines with respect to the lines of sites in the array is such that the distance between nearest edges of sites in adjacent lines is greater than lines through those edges in a direction parallel to the radiation lines used for scanning. The resulting system experiences less crosstalk and a greater ability to distinguish between neighboring sites in resulting images.Type: GrantFiled: September 3, 2010Date of Patent: September 20, 2011Assignee: Illumina, Inc.Inventor: Robert Kain
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Publication number: 20110204212Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: ApplicationFiled: May 2, 2011Publication date: August 25, 2011Applicant: ILLUMINA, INC.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Publication number: 20110172118Abstract: The present disclosure relates to composite arrays of various formats for simultaneous processing of multiple samples. Methods of making and using such arrays are also disclosed.Type: ApplicationFiled: March 24, 2011Publication date: July 14, 2011Inventors: Robert Kain, Todd Dickinson
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Patent number: 7960685Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: August 6, 2009Date of Patent: June 14, 2011Assignee: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Publication number: 20100328732Abstract: A scanning technique for imaging sites in an array includes illuminating or irradiating sites in lines of the array, and collecting returned radiation from the sites for imaging. The sites are sequentially scanned by means of confocally directed radiation lines from source optics. The orientation of the radiation lines with respect to the lines of sites in the array is such that the distance between nearest edges of sites in adjacent lines is greater than lines through those edges in a direction parallel to the radiation lines used for scanning The resulting system experiences less crosstalk and a greater ability to distinguish between neighboring sites in resulting images.Type: ApplicationFiled: September 3, 2010Publication date: December 30, 2010Applicant: ILLUMINA INC.Inventor: Robert Kain
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Patent number: 7813013Abstract: A scanning technique for imaging sites in an array includes illuminating or irradiating sites in lines of the array, and collecting returned radiation from the sites for imaging. The sites are sequentially scanned by means of confocally directed radiation lines from source optics. The orientation of the radiation lines with respect to the lines of sites in the array is such that the distance between nearest edges of sites in adjacent lines is greater than lines through those edges in a direction parallel to the radiation lines used for scanning. The resulting system experiences less crosstalk and a greater ability to distinguish between neighboring sites in resulting images.Type: GrantFiled: November 21, 2006Date of Patent: October 12, 2010Assignee: Illumina, Inc.Inventor: Robert Kain
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Patent number: 7791013Abstract: A line scanning arrangement for imaging microarrays includes a line illuminator that converts output from one or more lasers to a radiation line. The laser output passes through a single mode fiber and a module that converts the laser light to the radiation line. The line is confocally directed to sites on the microarray, and retrobeams returned from the sites are collected on an imaging detector. The microarray is moved in the imaging apparatus so as to progressively illuminate an array or matrix of sites for imaging.Type: GrantFiled: November 21, 2006Date of Patent: September 7, 2010Assignee: Illumina, Inc.Inventors: Mark Wang, Wenyi Feng, Robert Kain
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Publication number: 20100187115Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.Type: ApplicationFiled: November 25, 2009Publication date: July 29, 2010Applicant: ILLUMINA CORPORATIONInventors: Jonathan Posner, Kamil Salloum, Michal Lebl, Mark Reed, Dale Buermann, Matthew Hage, Bryan Crane, David Heiner, Robert Kain
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Publication number: 20100012825Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: ApplicationFiled: August 6, 2009Publication date: January 21, 2010Applicant: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 7589315Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: October 11, 2007Date of Patent: September 15, 2009Assignee: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain