Patents by Inventor Robert Karasiewicz

Robert Karasiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peg-interferon conjugates
    Patent number: 5382657
    Abstract: Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: January 17, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Karasiewicz, Carlo Nalin, Perry Rosen