Abstract: A method and a radio network node for managing a request for a radio access bearer. The radio network node determines a first value relating to utilization of radio resources in a first set of subframes. The first set of subframes includes a second set of subframes, dedicated for transmission by the radio network node to multiple radio communication devices, and a third set of subframes. The radio network node determines a second value relating to utilization of radio resources in the third set of subframes. The radio network node receives the request and obtains an indication relating to a capability of a radio communication device to receive transmission in one or more of the second set of subframes. The radio network node determines a response to the request based on the first value, the second value and the indication, and sends the response to the network node.

Abstract: A method and apparatus for dynamically allocating a time delay indicator value and/or random access parameters for sending to a mobile terminal during a Random Access procedure. The time delay indicator value indicates a time delay during which the mobile terminal is restricted from attempting a further Random Access procedure. At least one factor relating to monitored network conditions is determined. The time delay indicator value and/or other random access parameters are allocated on the basis of the factor. The time delay indicator value and/or random access parameters are then sent to the mobile terminal. This ensures that time delay indicator values can be dynamically adjusted depending on network conditions.

Abstract: Network node (110) and method (600) in a network node (110), for admission control of an additional radio access bearer based on load of control channel elements on a control channel, assigned by a scheduler (700) comprised in the network node (110). The method (600) comprises assigning (601), by the scheduler (700), control channel elements on the control channel for already admitted radio access bearers. Further, a first and a second load of the control channel is computed (606, 607) based on the usage of assigned control channel elements subframes on which both downlink assignments and uplink grants are enabled, and on which downlink assignments are enabled, respectively. If any of the first or second loads exceeds a respective threshold value, the radio access bearer to be admitted is rejected (609A).

Abstract: The invention relates to handover of a mobile station (12) from a source cell (C1) to a target cell (C2) in a wireless communication network (10, 11). According to the invention communication improving data in relation to communication between the source cell and the mobile station (12) is collected by a communication improving node (14) prior to handover and communication improving physical layer data being at least based on said collected communication improving data is transferred to a device (41) handling communication between the target cell and the mobile station. The communication handling device then uses the communication improving physical layer data to improve the quality of the initial communication between the mobile station and the target cell after handover to the target cell.

Abstract: A method of determining active concentration of an analyte in a sample comprises the steps of: (a) contacting a laminar flow of the sample with a plurality of solid phase surfaces or surface area supporting a ligand capable of specifically binding the analyte, each surface or surface area having a different ligand density, (b) determining the initial binding rate (dR/dt) of analyte to the ligand at each ligand-supporting surface or surface area, (c) from the determined initial binding rates determining the initial binding rate corresponding to transport-limited interaction at the surfaces or surface areas, and (d) from the initial binding rate determined in step (c) determining the active analyte concentration.

Abstract: A method of determining active concentration of an analyte in a liquid sample, comprises the steps of: (a) contacting a laminar flow of the sample with a solid phase surface or surface area supporting a ligand capable of specifically binding the analyte at at least two different flow rates and under partially or completely mass transport limited conditions; (b) determining the initial binding rate dR/dt of analyte to the ligand at the ligand-supporting surface or surface area, and (c) fitting the initial binding rate data obtained in step (b) to a kinetic interaction model that includes a term for mass transport to obtain the active analyte concentration, wherein steps (a) and (b) are performed at a plurality of different dilutions of the liquid sample, and wherein in step (c) at least several of the plurality of dilutions of the liquid sample are in included in a global fit of initial binding rate data to the kinetic interaction model.

Abstract: A method is provided for determining binding stoichiometry for the interaction between a first molecule and a second molecule forming a complex between them. Either (i) a solution having a fixed initial active concentration of the first molecule is titrated with solutions of varying active concentrations of the second molecule, and the free active concentrations of the second molecule are measured; or (ii) a solution with fixed initial concentrations of the first molecule and the second molecule is incubated, and the free active concentrations of both molecules are measured. In the first case, the binding stoichiometry can be determined from the initial concentration values of both molecules and the free concentration value(s) of the second molecule at saturation; and in the second case from the initial concentration values of both molecules and the free concentration values of both molecules.

Abstract: A charging device (100) and method (600) are described herein that can segment subscribers on a service class level and then can further segment those subscribers on an account level by using a service offerings parameter (105). The subscribers use communication services such as circuit switched voice, SMS, MMS and/or GPRS.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method of characterizing a population of antibodies to an antigen comprises contacting a sensor surface having the antigen immobilized thereto with a sample containing the antibody population to bind antibodies to the surface, and detecting dissociation of antibodies from the sensor surface during a dissociation phase when sample no longer contacts the surface. Based on the dissociation behaviour, the antibody population is characterized in terms of subpopulations of more and less stable antibodies, respectively. The method may be used to determine the immunogenicity of drug by monitoring the appearance of anti-drug antibodies in a patient over time, and determining any shift in proportions between more stable and less stable antibodies.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: The present invention relates to a method for analysing a cell sample for cell surface-bound or intracellularly bound analytes by providing an array of immobilised specific binding agents for a set of different ligands, where each ligand is specific to a respective cell surface-bound or intracellularly bound analyte, and using the array and the set of ligands in an inhibition type or a direct type assay format to determine cell surface-bound or intracellularly bound analytes in the cell sample. The invention also relates to assay kits for cell characterization.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: The invention relates to a method of determining the binding site specificity of an analyte to a ligand having at least two different binding sites, which method comprises immobilizing the ligand to a solid support, mixing the analyte with a reversibly binding reference analyte which has a dissociation behaviour that differs significantly from that of the analyte, contacting the mixture with the ligand to determine dissociation characteristics for the mixture, and determining therefrom the binding site specificity of the analyte in relation to the reference analyte. The invention also relates to an analytical system for carrying out the method, and to a computer program, computer program product and computer system for performing the method.