Patents by Inventor Robert Kastelein

Robert Kastelein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL10R?/IL2R? synthetic cytokines
    Patent number: 12540188
    Abstract: Provided herein are IL10R?/IL2R? binding molecules that bind to IL10R? and IL2R? and comprise an anti-IL2R? sdAb and an anti-IL2R? VHH antibody.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: February 3, 2026
    Assignee: SYNTHEKINE, INC.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Mahalakshmi Ramadass, Sandro Vivona
  • COMPOSITIONS AND METHODS RELATED TO RECEPTOR PAIRINGS
    Publication number: 20250376528
    Abstract: Provided herein are receptor binding proteins that bind to either natural cytokine receptor pairs or non-natural cytokine receptor pairs to create signaling diversity beyond natural receptor pairings.
    Type: Application
    Filed: June 18, 2025
    Publication date: December 11, 2025
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • COMPOSITIONS AND METHODS RELATED TO RECEPTOR PAIRINGS
    Publication number: 20250340656
    Abstract: Provided herein are receptor binding proteins that bind to either natural cytokine receptor pairs or non-natural cytokine receptor pairs to create signaling diversity beyond natural receptor pairings.
    Type: Application
    Filed: June 18, 2025
    Publication date: November 6, 2025
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • IL10RB BINDING MOLECULES AND ENCODING NUCLEIC ACIDS
    Publication number: 20250333521
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL10Rb, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: March 31, 2025
    Publication date: October 30, 2025
    Inventors: Robert Kastelein, Sandro Vivona, Deepti Rokkam, Patrick J. Lupardus
  • COMPOSITIONS AND METHODS RELATED TO IL2 RECEPTOR BINDING
    Publication number: 20250333520
    Abstract: Provided herein am IL2R binding proteins that bind to IL2R? and IL2R? and comprise an anti-IL2R? VHH antibody and an anti-IL2R? VHH antibody.
    Type: Application
    Filed: January 11, 2022
    Publication date: October 30, 2025
    Inventors: Robert Kastelein, Rene De Waal Malefyt, Deepti Rokkam, Patrick Lupardus, Sandro Vivona
  • GP130 binding molecules and methods of use
    Patent number: 12448457
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human gp130, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: October 21, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • COMPOSITIONS AND METHODS RELATED TO IL27 RECEPTOR BINDING
    Publication number: 20250179198
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Application
    Filed: November 13, 2024
    Publication date: June 5, 2025
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • IL27RAlpha BINDING MOLECULES AND METHODS OF USE
    Publication number: 20250171548
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL27R?, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: October 21, 2024
    Publication date: May 29, 2025
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • COMPOSITIONS AND METHODS RELATED TO RECEPTOR PAIRING
    Publication number: 20250163162
    Abstract: Provided herein are IL10R?/IL2R? binding proteins that bind to IL10R? and IL2R? and comprise an anti-IL10R? VHH antibody and an anti-IL2R? VHH antibody.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 22, 2025
    Inventors: Robert Kastelein, Sandro Vivona, Deepti Rokkam, Patrick Lupardus, Mahalakshmi Ramadass
  • IL10 RECEPTOR BINDING MOLECULES AND METHODS OF USE
    Publication number: 20250163167
    Abstract: Provided herein are IL10R binding molecules that bind to IL10Ra and IL10Rb and comprise an IL10Rb sdAb and an IL10Rb VHH antibody.
    Type: Application
    Filed: October 2, 2024
    Publication date: May 22, 2025
    Inventors: Robert Kastelein, Mahalakshmi Ramadass, Sandro Vivona, Deepti Rokkam, Patrick J. Lupardus
  • IL10RA binding molecules and methods of use
    Patent number: 12297281
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL10Ra, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: May 13, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IL12 receptor synthetic cytokines and methods of use
    Patent number: 12291572
    Abstract: Provided herein are IL12R binding molecules that bind to IL12Rb1 and IL12Rb2 and comprise an anti-IL12Rb2 sdAb and an anti-IL12Rb2 VHH antibody.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: May 6, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus
  • IL10RB binding molecules and encoding nucleic acids
    Patent number: 12286482
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL10Rb, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: April 29, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Sandro Vivona, Deepti Rokkam, Patrick J. Lupardus
  • IL2RB binding molecules and methods of use
    Patent number: 12234291
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of IL2Rb, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: February 25, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • Compositions and methods related to IL27 receptor binding
    Patent number: 12209132
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Grant
    Filed: September 11, 2023
    Date of Patent: January 28, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • IL2RB/IL2G SYNTHETIC CYTOKINES
    Publication number: 20250019453
    Abstract: Provided herein are IL2R binding molecules that bind to IL2Rb and IL2Rg and comprise an IL2Rg sdAb and an anti-IL2Rg VHH antibody.
    Type: Application
    Filed: August 9, 2024
    Publication date: January 16, 2025
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Rene De Waal Malefyt, Sandro Vivona
  • IL27RAlpha binding molecules and methods of use
    Patent number: 12157773
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL27R?, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: December 3, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IL23R BINDING MOLECULES AND METHODS OF USE
    Publication number: 20240376217
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL23R, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: May 6, 2024
    Publication date: November 14, 2024
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • IL10 receptor binding molecules and methods of use
    Patent number: 12139545
    Abstract: Provided herein are IL10R binding molecules that bind to IL10Ra and IL10Rb and comprise an IL10Rb sdAb and an IL10Rb VHH antibody.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: November 12, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Mahalakshmi Ramadass, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IFNGR binding synthetic cytokines and methods of use
    Patent number: 12122839
    Abstract: Provided herein are IFNGR binding molecules that bind to IFNGR1 and IFNGR2 and comprise an anti-IFNGR2 sdAb and an anti-IFNGR2 VHH antibody.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: October 22, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus