Abstract: Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. The functional description of the endogenous immunoglobulin loci yields an animal whose antibody repertoire in response to antigen is fully human. In the preferred embodiment, the human immunoglobulin locus is at least as large as the native human locus and exhibits functional class switching to yield IgG isotype antibodies. In addition to monoclonal antibodies secreted from immortalized B cell populations, polyclonal antibodies may be obtained from eggs laid by the transgenic chickens of the invention.

Abstract: A multi-pass friction stir weld joint and method for forming such joints are provided. The multi-pass weld joint is formed of at least first-pass and second-pass friction stir weld joints that are disposed in the workpiece in a substantially parallel configuration. The first- and second-pass joints define transversely opposite advancing and retreating sides, and the second-pass joint is disposed to at least partially overlap the retreating side of the first-pass joint. Thus, at least some of the material of the workpiece in the first-pass joint is processed during the formation of the second-pass joint.

Abstract: The present invention is an orally administered pharmaceutical composition that provides for the controlled release of magnesium. The composition has an interactive agent component and a magnesium component which has an enteric coating that controls the release of the magnesium until the composition is in the small intestine or colon. The other component is released in the stomach and is substantially absorbed prior to the release of the magnesium component. Normally, the interactive agent component decreases the absorption of magnesium when the two components are released simultaneously in the gastrointestinal tract.

Abstract: A method and apparatus wherein a software scheduling agent resides on a communication network and/or client device, such as location-aware wireless communication appliances, television set top boxes, or other end user client devices is disclosed. The software scheduling agent is part of a probabilistic modeling system in which the scheduler operates to perform constrained random variation with selection. Digital content is generated, organized, and stored on the communication network and/or the client devices. An electronic digital content wrapper, which holds information in the form of data and metadata related to the digital content is associated with each item of digital content. Contextual profiles for each user and each item of digital content are established by the users and the network and maintained by a service provider on the communication network.

Abstract: A floor cleaner is provided for cleaning a floor, where the floor cleaner has a front and a rear and includes: a sweeper for sweeping the floor; a scrubber, connected to the sweeper and located in the rear of the sweeper, for wetting and cleaning the floor; and a burnisher, connected to the scrubber and located in the rear of the scrubber, for burnishing the floor.

Abstract: A floor cleaner is provided for cleaning a floor, where the floor cleaner has a front and a rear and includes: a sweeper for sweeping the floor; a scrubber, connected to the sweeper and located in the rear of the sweeper, for wetting and cleaning the floor; and a burnisher, connected to the scrubber and located in the rear of the scrubber, for burnishing the floor.

Abstract: A floor cleaner is provided for cleaning a floor, where the floor cleaner has a front and a rear and includes: a sweeper for sweeping the floor; a scrubber, connected to the sweeper and located in the rear of the sweeper, for wetting and cleaning the floor; and a burnisher, connected to the scrubber and located in the rear of the scrubber, for burnishing the floor.

Abstract: A procedure and method which use a debit, stored value, or prepaid stored value card, or a similar card or account that has a value but does not extend credit to the card holder, to provide a designated funding amount to a selected non-profit or charitable organization or entity identified by the card where the funding amount is transferred with each transaction, such as a purchase, deposit (load) or cash withdrawal, using that card.

Abstract: Compositions and methods for maintaining healthy mobile joints and cartilage in humans and animals are disclosed. The composition comprises a glucosamine component dispersed in a controlled-release matrix system capable of releasing the glucosamine over a designated time period. In another aspect, the invention provides compositions and methods for maintaining health mobile joints and cartilage in humans and animals without adversely affecting glucose regulation.

Abstract: Compositions and methods of treatment for conditions in humans and animals which have an inflammatory component, are disclosed. The composition comprises a glucosamine component dispersed in a controlled-release matrix system capable of releasing the glucosamine over a designated time period. In another aspect, the invention provides compositions and methods for the treatment of arthritis in humans and animals without adversely effecting glucose regulation.

Abstract: The present invention is an orally administered pharmaceutical composition that provides for the controlled release of magnesium. The composition has an interactive agent component and a magnesium component which has an enteric coating that controls the release of the magnesium until the composition is in the small intestine or colon. The other component is released in the stomach and is substantially absorbed prior to the release of the magnesium component. Normally, the interactive agent component decreases the absorption of magnesium when the two components are released simultaneously in the gastrointestinal tract.

Abstract: A method for creating realistic synchronisation of a sound sample including speech to the motion of a lenticular image is disclosed, together with a device for achieving such synchronisation. The device includes a lenticular image consisting of a number of different individual images spliced together and printed on a substrate which can be moved relative to a lenticular screen to give the appearance of animation that the lenticular image. The sound sample is ideally stored in the memory of a sound chip and the synchronisation is achieved using a processor.

Abstract: A method is provided for obtaining a measure characteristic of a homeopathic preparation that affects the expression of at least one gene, the method comprising contacting the preparation with a gene in a gene expression system; and measuring the level of expression of the gene; wherein the level of expression constitutes the measure characteristic of the contents of the preparation.

Abstract: Novel transcription initiation regions that provide for enhanced transcription of a DNA sequence, particularly a plant sequence, are provided.

Abstract: Novel transcription initiation regions that provide for enhanced transcription of a DNA sequence, particularly a plant sequence, are provided.

Abstract: Novel transcription initiation regions that provide for enhanced transcription or a DNA sequence, particularly a plant sequence, are provided.

Abstract: Novel transcription initiation regions that provide for enhanced transcription of a DNA sequence, particularly a plant sequence, are provided.

Abstract: Novel transcription initiation regions that provide for enhanced transcription of a DNA sequence, particularly a plant sequence, are provided.