Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A microscope for examining a specimen configured to receive a first light source or a second light source. The first light source being configured to emit a first output light through a first pupil, and the second light source being configured to emit a second output light through a second pupil that is different than the first pupil. The microscope comprises a frame, a source objective, and first and second optical assemblies. The first and second optical assemblies are removably connectable to the frame. The first optical assembly comprises a first set of optical elements that are configured to pass the first output light to an imaging pupil of the source objective, and the second optical assembly comprises a second set of optical elements configured to pass the second output light to the imaging pupil.

Abstract: An optical measurement system measurement system for examining a sample. The measurement system comprises an internally reflective element, a stage, an optical assembly, a chassis, and a sensor. The internally reflective element has a contact surface. The stage is positioned below the internally reflective element. The stage and the internally reflective element are configured to apply a force to the sample. The optical assembly comprises a light source and a light detector. The optical assembly is configured to scan the sample by directing source light from the light source towards the contact surface and detecting source light optically interacting with the contact surface by the light detector. The chassis is configured to support the optical assembly and the internally reflective element. The sensor is mounted to the chassis and configured to detect the force applied to the sample by the internally reflective element and the stage.

Abstract: An embodiment of a calibration element for an analytical microscope is described that comprises a substantially non-periodic pattern of features that exhibit contrast when illuminated by a light beam.

Abstract: An embodiment of a calibration element for an analytical microscope is described that comprises a substantially non-periodic pattern of features that exhibit contrast when illuminated by a light beam.

Abstract: A system and method for managing the distributed generation of power from a plurality of vehicles is provided. In one embodiment, the method includes determining location information for the plurality of vehicles, determining that a demand for power in a first portion of the power grid has reached a power threshold, determining that the location information associated with a set of the plurality of vehicles satisfies a similarity threshold with the first portion of the power grid, and transmitting a request to a first group of vehicles in the set of vehicles to discharge power. In addition, the method may include receiving a response from at least some of the electric vehicles to which a request was transmitted, and determining whether to request the discharge of power from additional vehicles in the set of the plurality of vehicles based, at least in part, on the number of responses containing a confirmation of the discharge of power.

Abstract: A system, method and device for controlling the voltage supplied to a customer premises that is supplied power from a substation via a power distribution network is provided and wherein a resident of the customer premises obtains internet access service via an internet access network. In one embodiment, the method includes measuring a voltage at an electrical outlet of the customer premises to provide voltage data with the device, determining whether the measured voltage is beyond a threshold voltage with the device or a remote computer, transmitting the voltage data over the internet access network of the customer premises to the remote computer from the device, and adjusting a voltage supplied to the power distribution network by the substation if the voltage is beyond a threshold voltage.

Abstract: A system and method for managing the stored power of a plurality of vehicles connected to the power grid is provided. In one embodiment the method includes determining location information of each of the plurality of vehicles connected to the power grid, determining that a demand for power in a portion of the power grid has reached a power threshold, determining that the location information associated with a set of the plurality of vehicles satisfies a similarity threshold with the portion of the power grid, determining that a subset of the set of vehicles has stored power that satisfies a power availability threshold, and transmitting a command to at least one vehicle of the subset of vehicles to discharge power onto the power grid. The portion of the power grid may comprise a medium voltage power line or a substation.

Abstract: A system and method for managing the distributed generation of power from a plurality of vehicles is provided. In one embodiment, the method includes determining location information for the plurality of vehicles, determining that a demand for power in a first portion of the power grid has reached a power threshold, determining that the location information associated with a set of the plurality of vehicles satisfies a similarity threshold with the first portion of the power grid, and transmitting a request to a first group of vehicles in the set of vehicles to discharge power. In addition, the method may include receiving a response from at least some of the electric vehicles to which a request was transmitted, and determining whether to request the discharge of power from additional vehicles in the set of the plurality of vehicles based, at least in part, on the number of responses containing a confirmation of the discharge of power.

Abstract: A system and method for distributing content to a plurality of digital photo frames disposed in a plurality of customer premises is provided. In one embodiment, the method includes receiving a plurality of content and storing the content in memory. The method may include converting at least some of the content from a first format to a second format suitable for display by a digital photo frame and transmitting at least some of the content via the Internet to each of the plurality of digital photo frames for display. The content may include photos, emails, text messages, faxes, utility data, and/or other content. The method may also include storing information of a user in association with each of the plurality of digital photo frames, storing content configuration information in memory for each user, and selecting the content for transmission based on the content configuration information of the user associated with each digital photo frame.

Abstract: A system, device, and method of using a power line communication device that is communicatively connected to a low voltage power line to establish communications with one or more electronic utility meters is provided. In one embodiment the method includes setting an encryption key parameter to a first encryption key used by the one or more electronic utility meters, establishing communications via one or more low voltage power lines with at least some of the utility meters using the first encryption key, assessing the quality of communications with at least some of the utility meters, transmitting communications quality data to a remote computer system; receiving information of one or more assigned meters from the remote computer system; and storing information of the assigned meters in memory.

Abstract: The present invention is a tool or apparatus relating to the safety of an individual using a ladder. The apparatus is simple in design and use being crafted of a single piece of metal shaped into a three sided open ended box. The middle side being extended into a point to be inserted into the ground. In the preferred form, it is used in a pair or set of two, positioned at the base of a ladder, one at each foot. The apparatus need not be attached to the ladder by any means, merely inserted into the ground surrounding the foot so as to prevent the foot from slipping or “kicking” out and causing the ladder to slip.

Abstract: A nanocomposite material suitable for electrical insulation includes a polymer compounded with a substantially homogeneously distributed functionalized nanoparticle filler. The nanocomposite material is produced by compounding the polymer with the functionalized nanoparticle filler by imparting a shear force to a mixture of the polymer and filler capable of preventing agglomeration of the filler whereby the filler is substantially homogeneously distributed in the nanocomposite material. The electrical insulation may be adapted for AC or DC high voltage, and may also be adapted for low or medium voltage to prevent formation of water tree structures.