Abstract: A composition for use in a method of providing sustained energy release over time in a subject is described. The composition comprises or consists of microparticles comprising high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, GLP-1 stimulative, non-porous carrier configured for release of the high GI carbohydrate in the ileum, wherein the composition is administered orally to the subject.

Abstract: A method of producing a denatured pea protein solution comprises the steps of mixing pea protein with an alkali solvent to provide a 1-10% pea protein solution (w/v) having a pH of at least 10, resting the pea protein solution for at least 15 minutes, heating the pea protein solution under conditions sufficient to heat-denature the pea protein without causing gelation of the pea protein solution, and rapidly cooling the denatured pea protein solution to prevent gelation, wherein at least 90% of the pea protein in the denatured pea protein solution is soluble. Also described is a method of producing microparticles having a denatured pea protein matrix, the method comprising the steps of providing a denatured pea protein solution according to the invention, treating the denatured pea protein solution to form microdroplets; and cross-linking and chelating the droplets to form microparticles.

Abstract: A method of producing coated microcapsules comprises the steps of producing microcapsules by cold gelation having a denatured or hydrolysed protein matrix and an active agent contained within the matrix, and drying the microcapsules. A meltable coating composition comprising wax and oil and configured to have a melting point of about 70° C. to about 100° C.

Abstract: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.

Abstract: “Microcapsules containing curcumin, and methods for the production thereof” A microcapsule suitable for delivery intact to the mammalian lower intestine via an oral route and having curcumin homogenously distributed in pockets within a crosslinked functional matrix, in which the microcapsule comprises at least 30% curcumin (w/w). Matrices formed of pea protein or Shellac have been proposed, using both spray-drying and cold gelation methods. Microcapsules of the invention are resistant to degradation in the stomach and release curcumin slowly in the ileum, and exhibit improved resistance of encapsulated curcumin to thermal and high/low pH environments.

Abstract: The method for predictive corruption risk assessment includes identifying a target for assessing corruption risk. A set of misconduct data requests are provided. Misconduct input associated with each misconduct data request in the set of misconduct data requests is received. A set of predictive factors data requests are provided. Predictive factors input associated with each predictive factors data request in the set of predictive factors data requests is received. The misconduct input and the predictive factors input are aggregated. The set of predictive factors data requests statistically correlate with the set of misconduct data requests. Each predictive factors data request of the set of predictive factors data requests is from at least one or more categories. The aggregated misconduct and predictive factors inputs are analyzed. A report based on the analysis is generated and the report reflects the aggregated misconduct and predictive factors inputs.

Abstract: A composition for use in a method of providing sustained energy release over time in a subject is described. The composition comprises or consists of microparticles comprising high glycaemic index (Gl) carbohydrate contained within a gastric-resistant, ileal-sensitive, GLP-1 stimulative, non-porous carrier configured for release of the high Gl carbohydrate in the ileum, wherein the composition is administered orally to the subject.

Abstract: A therapeutic or non-therapeutic method of inducing satiety in a mammal is described. The method comprises administering to the mammal a composition comprising microparticles, in which the microparticles comprise lipid contained within a gastric-resistant, ileal-sensitive, carrier configured for release of the lipid in the ileum, wherein the composition is administered 1-3 hours prior to a meal. The carrier is a protein, typically denatured or hydrolysed plant or dairy protein, that is polymerised to form a lipid containing shell or matrix.

Abstract: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.

Abstract: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce micro-particles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.

Abstract: A method of producing a denatured pea protein solution comprises the steps of mixing pea protein with an alkali solvent to provide a 1-10% pea protein solution (w/v) having a pH of at least 10, resting the pea protein solution for at least 15 minutes, heating the pea protein solution under conditions sufficient to heat-denature the pea protein without causing gelation of the pea protein solution, and rapidly cooling the denatured pea protein solution to prevent gelation, wherein at least 90% of the pea protein in the denatured pea protein solution is soluble. Also described is a method of producing microparticles having a denatured pea protein matrix, the method comprising the steps of providing a denatured pea protein solution according to the invention, treating the denatured pea protein solution to form microdroplets; and cross-linking and chelating the droplets to form microparticles.

Abstract: Disclosed herein are ketamine derivatives that have been modified to reduce or prevent transference across the blood brain barrier. The ketamine derivatives will allow the reduction of pain in the patients without complications associated with psychotropic effects typically associated with unmodified ketamine.

Abstract: The cup holder for a drinking game is a triangular multi-cup beverage tray and freezer pack insert that holds and chills multiple cups in a “billiard ball rack” formation for use in the drinking game “Beer-Pong,” “Beirut,” or variations thereof. The cup holder for a drinking game includes cup pockets, indentations or channels in a triangular row formation (front to back) of one cup, two cups, three cups, etc., which are formed in the freezer pack The cup holding freezer pack fits into the triangular tray for added stability. Rubber or neoprene feet are disposed symmetrically on an underside of the bottom of the tray to provide traction during use. Preferably, the placement and depth of the cup pockets provide for the correct orientation of the cups for optimal playing of the drinking game with standard 16-ounce party cups.