Abstract: The invention relates generally to a process for isolating subpopulations of EVs to identify biomarkers useful identifying, determining the progression of, and/or prognosing a disease, including a neurological disease. More particularly, the present invention relates to detection technology of various exosomal biomarkers including proteins, protein modifications, sugars, RNA, DNA, lipids, and metabolites, and combinations thereof.

Abstract: The invention relates generally to the use of microvesicle biomarkers such as nucleic acids, including nucleic acid signatures, and/or proteins for assessing a kidney transplant rejection in a patient. The invention further relates to assessing, and/or to monitoring kidney transplant rejection in patients who have received a renal transplant.

Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).

Abstract: The present disclosure relates to methods for treating glioblastoma in a subject in need thereof using gene signatures in exosomal RNA derived from the subject. The gene signatures comprise: at least one of FAM229B, ZNF35, CTD-2647L4.4, CABP5, CYP20A1, CEP126, DTX2P1-UPK3BP1-PMS2P11, RP11-507K12.1, KRBA2, CALD1, LRFN1, RP2, SLC2A13, CDKL3, SLC8A3, ANTXR2, TIGD5, AC074289.1 RP11-932O9.7; at least one of tRNA-Lys-CTT-2-2, tRNA-Pro-AGG-2-7, LAMTOR2, RAD51AP1, DENND2A, A1BG, THSD1, CSF1, RP11-332M2.1, ZNF717, ZNF860, ORC6, Clorf50, PSPH, HIST1H4C, CYP2U1, THAP8, TMEM192, NAA20; or at least one of CREBBP, CXCR2 and S100A9. The treatment methods comprise measuring the expression level of at least one of the aforementioned genes in exosomal RNA from a subject and administering to the subject a glioblastoma treatment based on the expression level(s).

Abstract: The present disclosure relates to methods for detecting and treating bladder cancer in a subject using the gene expression level measurements from exosomes derived from the subject.

Abstract: The invention relates generally to a process for isolating subpopulations of EVs to identify biomarkers useful identifying, determining the progression of, and/or prognosing a disease, including a neurological disease. More particularly, the present invention relates to detection technology of various exosomal biomarkers including proteins, protein modifications, sugars, RNA, DNA, lipids, and metabolites, and combinations thereof.

Abstract: The present disclosure relates to methods for providing a clinical assessment of a subject in need thereof using the gene expression level measurements from exosomes derived from the subject.

Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).

Abstract: The invention relates generally to the use of microvesicle biomarkers such as nucleic acids, including nucleic acid signatures, and/or proteins for assessing a kidney transplant rejection in a patient. The invention further relates to assessing, and/or to monitoring kidney transplant rejection in patients who have received a renal transplant.

Abstract: Methods and apparatus for operating an electronic component, such as an NEC communication device, allow performance of at least one operation based, at least in part, on the relative positions and/or motions of the electronic component over time. Information regarding motion of the electronic component is used to determine one or more actions, or one or more state changes of the electronic component. Such an electronic component is motion-aware. Since this motion-awareness gives the electronic component the ability to take one or more actions, or to make one or more state changes, based, at least in part, on information indicative of its relative position or motions over time, various states and/or functions of the electronic device may be initiated and/or controlled by subjecting it to one or more movements or motions.

Abstract: NFC communication is utilized to provide methods, apparatus and systems for increasing the security of cryptographic keys and cryptographic processes. For the encryption and decryption of a message, public key cryptography requires the use of a pair of keys, i.e., the public key and the private key. Various embodiments of the present invention provide storage of information needed for one or more aspects of encrypting and/or decrypting messages, wherein that information is made available through an NFC communications interface. An NFC-enabled device is brought into physical proximity with a computational platform that is executing, or otherwise providing access to, an email client. Once the NFC-enabled device and the computational platform are within NFC communication range of each other, transfer of information needed to set up an encryption and/or decryption process takes place.

Abstract: Methods and apparatus for operating an electronic component, such as an NEC communication device, allow performance of at least one operation based, at least in part, on the relative positions and/or motions of the electronic component over time. Information regarding motion of the electronic component is used to determine one or more actions, or one or more state changes of the electronic component. Such an electronic component is motion-aware. Since this motion-awareness gives the electronic component the ability to take one or more actions, or to make one or more state changes, based, at least in part, on information indicative of its relative position or motions over time, various states and/or functions of the electronic device may be initiated and/or controlled by subjecting it to one or more movements or motions.

Abstract: A kit for forming a hollow block assembly to be used to construct a wall having a corner, the kit consisting of face panels, right and left corner panels and a plurality of fasteners, each panel comprising a plurality of spaced apart flanges extending perpendicularly from and attached to each panel so that a hollow block structure is assembled when the flanges of the panels are connected together, directly or indirectly, by the fasteners, the right and left corner panels being dimensioned to interconnect at the edges thereof to form a corner section of a wall.

Abstract: A kit for forming a hollow block assembly to be used to construct a wall, the kit consisting of two face panels and a plurality of fasteners, each face panel comprising a plurality of spaced apart flanges extending perpendicularly from and attached to each panel so that a hollow block structure is assembled when the flanges of the face panels are connected together, directly or indirectly, by the fasteners.

Abstract: A kit for forming a hollow block assembly to be used to construct a wall, the kit consisting of two face panels and a plurality of fasteners, each face panel comprising a plurality of spaced apart flanges extending perpendicularly from and attached to each panel so that a hollow block structure is assembled when the flanges of the face panels are connected together, directly or indirectly, by the fasteners.

Abstract: A kit for forming a hollow block assembly to be used to construct a wall, the kit consisting of two face panels and a plurality of fasteners, each face panel comprising a plurality of spaced apart flanges extending perpendicularly from and attached to each panel so that a hollow block structure is assembled when the flanges of the face panels are connected together, directly or indirectly, by the fasteners.

Abstract: There is described a motion control device for preventing free-fall of electronics modules during vertical movement into or out of a supporting structure. The system comprises a rotatable element on the module or structure engageable with surface on the structure or module, respectively, for rolling movement therealong. The rotatable element is provided with a clutch or brake to provide resistance to rotation at least when the module is moving downward relative to the structure. The rotatable element may be a gear engageable with a toothed rack, or a friction roller engageable with a friction surface.

Abstract: A rack mountable shelf supports a plurality of field replaceable units (FRUs) in the form of server cartridges, or blades. The blades are provided with an enclosure that includes a metal portion and a plastics portion. The provision of a blade enclosure for the blade can protect the components of the blade from physical damage and can also isolate them from electrical, static and other effects that could be potentially damaging to the blade components. The use of metal can provide strength and electromagnetic interference shielding with a very thin layer. The use of plastics can provide lightness, flexibilty in design, and the avoidance of metal to metal contact to facilitate insertion and removal of the blades.

Abstract: A system configuration device provides system configuration information to a system unit. The device, for example a card, includes a circuit, circuit contacts, and a notch in one edge of thereof. The notch is configured to cooperate with a restraint when located in a card reading station for securing the card in the card reading station. A system configuration card reading station comprises a card receiver defining a slot for receiving the card, and a card reader including card reader contacts for contacting the circuit contacts on the card. The card reader contacts are located so as to contact the circuit contacts on the card when the card is received within the slot. The card receiver is configured to enable a restraint to engage the notch in the card for securing the card in the card reading station when the card is received within the slot.