Patents by Inventor Robert KLVANA

Robert KLVANA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing vortioxetine
    Patent number: 9920021
    Abstract: The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)phenyl)piperazine of formula (I) or its salt comprises a reaction of 2-(2,4-dimethylphenyl-sulphanyl)benzeneamine of formula (XI), wherein Me is methyl, with a suitable precursor of formation of piperazine ring of formula (XII), wherein LG is a leaving group and R is hydrogen or a protective group, in a suitable organic solvent, wherein the reaction is carried out without presence of a base in a neutral or acidic environment.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: March 20, 2018
    Assignee: Zentiva k.s.
    Inventors: Robert Klvana, Stanislav Radl, Jindrich Richter
  • METHOD OF PREPARING VORTIOXETINE
    Publication number: 20170204074
    Abstract: The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)pheny!)piperazine of formula (I) or its salt comprises a reaction of 2-(2,4-dimethylphenyl-sulphanyl)benzeneamine of formula (XI), wherein Me is methyl, with a suitable precursor of formation of piperazine ring of formula (X11), wherein LG is a leaving group and R is hydrogen or a protective group, in a suitable organic solvent, wherein the reaction is carried out without presence of a base in a neutral or acidic environment.
    Type: Application
    Filed: July 8, 2015
    Publication date: July 20, 2017
    Inventors: Robert KLVANA, Stanislav RADL, Jindrich RICHTER