Patents by Inventor Robert Koralewski

Robert Koralewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Pyrrolotriazines
    Publication number: 20240150362
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Jacek Chrzanowski, Anna Gzik, Joanna Brzezinska, Robert Koralewski, Lukasz Joachimiak, Karolina Rozga, Szymon Kapuscinski, Bartlomiej Borek, Mateusz Urban, Sylwia Ciastek-Iskrzycka, Julita Nowicka, Kamil Lisiecki, Roman Blaszczyk, Adam Golebiowski, Jacek Olczak
  • YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20230278996
    Abstract: Disclosed are novel assays for screening active compounds interfering with interaction between chitinase-like protein YKL-40 and chitin oligomers, as well as interfering with interaction between chitinase-like protein YKL-40 and heparan sulfate. Moreover, disclosed are novel active compounds identified by these assays as inhibitors of chitinase-like protein YKL-40, their therapeutic applications, and their use in biosensors measuring the level of chitinase-like protein YKL-40 in biological samples.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 7, 2023
    Inventors: Lukasz Krzeminski, Wojciech Czestkowski, Marzena Mazur, Gleb Andryianau, Sylwia Olejniczak, Michal Czeslaw Piotrowicz, Robert Koralewski, Elzbieta Pluta, Krzysztof Matyszewski, Michal Kowalski, Barbara Dymek, Rafal Koziel, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz, Katarzyna Krysztofiak
  • DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230219973
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: December 22, 2022
    Publication date: July 13, 2023
    Inventors: Jacek CHRZANOWSKI, Julita NOWICKA, Lukasz JOACHIMIAK, Robert KORALEWSKI, Sylwia OLEJNICZAK, Marzena MAZUR, BartlomieJ BOREK, Anna GZIK, Krzysztof MATYSZEWSKI, Sylwia CIASTEK-ISKRZYCKA, Piotr NIEDZIEJKO, Angelika MUCHOWICZ, Zbigniew ZASLONA, Roman BLASZCZYK, Jacek OLCZAK, Adam GOLEBIOWSKI
  • Substituted amino triazoles useful as chitinase inhibitors
    Patent number: 11638707
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 2, 2023
    Assignee: Molecure S.A.
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS
    Publication number: 20210015822
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: July 15, 2020
    Publication date: January 21, 2021
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal L. Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz
  • Substituted amino triazoles useful as human chitinase inhibitors
    Patent number: 10538508
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 21, 2020
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
    Publication number: 20190345137
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: February 15, 2019
    Publication date: November 14, 2019
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
  • Substituted amino triazoles useful as human chitinase inhibitors
    Patent number: 10208020
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: February 19, 2019
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elżbieta Maziarz, Michal Łukasz Kowalski
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
    Publication number: 20180258071
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: February 28, 2018
    Publication date: September 13, 2018
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal Lukasz Kowalski
  • Substituted amino triazoles useful as human chitinase inhibitors
    Patent number: 9944624
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: April 17, 2018
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michał C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elżbieta Maziarz, Michał Łukasz Kowalski
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
    Publication number: 20170066743
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 9, 2017
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal Lukasz Kowalski
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS
    Publication number: 20160368894
    Abstract: Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens.
    Type: Application
    Filed: September 1, 2016
    Publication date: December 22, 2016
    Inventors: Adam A. Golebiowski, Robert Koralewski, Wojciech J. Czestkowski, Krzysztof Matyszewski, Sylwia Olejniczak, Jacek P. Olczak, R. Paul Beckett
  • Substituted amino triazoles useful as acidic mammalian chitinase inhibitors
    Patent number: 9440953
    Abstract: Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 13, 2016
    Assignee: OncoArendi Therapeutics Sp. z o.o.
    Inventors: Adam Golebiowski, Robert Koralewski, Wojciech J. Czestkowski, Krzysztof Matyszewski, Sylwia Olejniczak, Jacek Olczak, Paul Beckett
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS
    Publication number: 20160176843
    Abstract: Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens.
    Type: Application
    Filed: December 4, 2015
    Publication date: June 23, 2016
    Inventors: Adam Golebiowski, Robert Koralewski, Wojciech J. Czestkowski, Krzysztof Matyszewski, Sylwia Olejniczak, Jacek Olczak, Paul Beckett