Patents by Inventor Robert Kotin

Robert Kotin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTOPARVOVIRUS AND TETRAPARVOVIRUS COMPOSITIONS AND METHODS FOR GENE THERAPY
    Publication number: 20240066080
    Abstract: Disclosed are recombinant virions that have a capsid protein, or a variant thereof, of a protoparvovirus or tetraparvovirus, and a nucleic acid that includes a heterologous nucleic acid.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 29, 2024
    Inventors: Robert Kotin, Sebastian Aguirre
  • Compositions and methods for the production of scAAV
    Patent number: 11697825
    Abstract: The present invention is directed to viral vectors and methods of their production and use.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 11, 2023
    Assignee: Voyager Therapeutics, Inc.
    Inventors: James McLaughlin, Robert Kotin
  • CLOSED-ENDED, LINEAR, DUPLEX ADENOASSOCIATED VIRUS DNA, AND USES THEREOF
    Publication number: 20230159953
    Abstract: Closed-ended, linear, duplex (CELiD) DNA molecules, recombinant AAV (rAAV), particles comprising CELiD DNA, methods of making such molecules and particles, and therapeutic applications of such particles.
    Type: Application
    Filed: January 9, 2023
    Publication date: May 25, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Lina Li, Robert Kotin
  • Closed-ended, linear, duplex adenoassociated virus DNA, and uses thereof
    Patent number: 11549125
    Abstract: Closed-ended, linear, duplex (CELID) DNA molecules, recombinant AAV (rAAV), particles comprising CELID DNA, methods of making such molecules and particles, and therapeutic applications of such particles.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: January 10, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Lina Li, Robert Kotin
  • REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)
    Publication number: 20220195459
    Abstract: The present invention relates to viral particles which exhibit self-regulatory or regulatable features.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 23, 2022
    Inventor: Robert KOTIN
  • AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20210338786
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 4, 2021
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • AADC polynucleotides for the treatment of Parkinson's disease
    Patent number: 11027000
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: June 8, 2021
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • Adeno-associated virus polynucleotides, polypeptides and virions
    Patent number: 10882886
    Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: January 5, 2021
    Assignees: CHILDREN'S MEDICAL RESEARCH INSTITUTE, THE SYDNEY CHILDREN'S HOSPITALS NETWORK (RANDWICK AND WESTMEAD) (INCORPORATING THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN), THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (WASHINGTON DC)
    Inventors: Claus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
  • CLOSED-ENDED, LINEAR, DUPLEX ADENOASSOCIATED VIRUS DNA, AND USES THEREOF
    Publication number: 20200270636
    Abstract: Closed-ended, linear, duplex (CELID) DNA molecules, recombinant AAV (rAAV), particles comprising CELID DNA, methods of making such molecules and particles, and therapeutic applications of such particles.
    Type: Application
    Filed: August 9, 2017
    Publication date: August 27, 2020
    Inventors: Lina LI, Robert KOTIN
  • CHIMERIC CAPSIDS
    Publication number: 20200149068
    Abstract: The present invention relates to viral vectors and methods of their production and use.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: Robert Kotin, Jinzhao Hou, James McLaughlin
  • Chimeric capsids
    Patent number: 10577627
    Abstract: The present invention relates to viral vectors and methods of their production and use.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 3, 2020
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Robert Kotin, Jinzhao Hou, James McLaughlin
  • AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20190358306
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Application
    Filed: August 14, 2019
    Publication date: November 28, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • AADC polynucleotides for the treatment of parkinson's disease
    Patent number: 10335466
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 2, 2019
    Assignee: VOYAGER THERAPEUTICS, INC.
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • ADENO-ASSOCIATED VIRUS POLYNUCLEOTIDES, POLYPEPTIDES AND VIRIONS
    Publication number: 20190135870
    Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
    Type: Application
    Filed: May 3, 2017
    Publication date: May 9, 2019
    Applicants: Children's Medical Research Institute, The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexanndra, The United States of America, as represented by the Secretary, Department of Health and Human
    Inventors: Claus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF AADC DEFICIENCY
    Publication number: 20190054158
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment, prophylaxis, palliation or amelioration of diseases, conditions and/or symptoms resulting from AADC deficiency and related inborn errors of neurotransmitter metabolism.
    Type: Application
    Filed: November 2, 2018
    Publication date: February 21, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20190008931
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 10, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20190008932
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 10, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20190008933
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 10, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF AADC DEFICIENCY
    Publication number: 20190000940
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment, prophylaxis, palliation or amelioration of diseases, conditions and/or symptoms resulting from AADC deficiency and related inborn errors of neurotransmitter metabolism.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 3, 2019
    Inventors: Robert Kotin, Adrian Philip Kells, Bernard Ravina
  • REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)
    Publication number: 20180245073
    Abstract: The present invention relates to CRISPR-AAV vectors and viral particles which exhibit self-regulatory or regulatable features.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 30, 2018
    Inventors: Robert Kotin, James McLaughlin, Jinzhao Hou