Abstract: Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Also disclosed are methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.

Abstract: A breech load pistol and conversion kit which may be adapted to the frame of a semi-automatic pistol, such as a Government 0.45 pistol. The present invention may provide a modified reinforced slide which is slidably mounted to the pistol frame and is adapted to include a pivotable barrel assembly mounted thereto. The barrel preferably is suitable for target pistol accuracy. The barrel assembly may be pivoted exposing the breech end for single shot loading for target shooting applications. The conventional semi-automatic pistol magazine or clip may be replaced with a modified clip acting as a breech release actuator having a lever mechanism which is operable to release a latch holding the barrel assembly in engagement with the slide. The present invention also provides a pistol with a gas relief port. The present invention further provides a rim ejector for ejecting spent cartridges using a camming action occurring during pivoting of the barrel assembly to a loading position.

Abstract: A breech load pistol conversion kit which may be adapted to the frame of a semi-automatic pistol. A modified slide is slidably mounted to the pistol frame and is adapted to include a pivotal barrel. A lever actuated breech release mechanism is also provided for unlocking and allowing the barrel to pivot. The present invention relates to a safety interface member slidably disposed with respect to the slide and the pistol frame. The member engages and disengages a disconnector in the frame to provide a safety against hammer release when the pistol the breech release mechanism is activated and the pistol is not in a firing position.

Abstract: A breech load pistol and conversion kit which may be adapted to the frame of a semi-automatic pistol, such as a Government 0.45 pistol. The present invention may provide a modified slide which is slidably mounted to the pistol frame and is adapted to include a pivotable barrel assembly mounted thereto. The barrel preferably is suitable for target pistol accuracy. The barrel assembly may be pivoted exposing the breech end for single shot loading for target shooting applications. The conventional semi-automatic pistol magazine or clip may be replaced with a modified clip acting as a breech release actuator having a lever mechanism which is operable to release a latch holding the barrel assembly in engagement with the slide. The present invention also provides a pistol with a gas relief port. The present invention further provides a rim ejector for ejecting spent cartridges using a camming action occurring during pivoting of the barrel assembly to a loading position.