Patents by Inventor Robert L. Arslanian

Robert L. Arslanian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of polyketides
    Patent number: 7323573
    Abstract: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: January 29, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventor: Robert L. Arslanian
  • Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
    Patent number: 6998256
    Abstract: Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example, Sorangium cellulosum and Myxococcus xanthus (recombinant). Epothilone can be purified from fermentation broth, for example by using resins, chromatography, and crystallization. Epothilone D can be crystallized from a binary solvent system in which water is the forcing solvent.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: February 14, 2006
    Assignee: Kosan Biosciences, Inc.
    Inventor: Robert L. Arslanian
  • Epothilone derivatives and methods for making and using the same
    Patent number: 6893859
    Abstract: This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: May 17, 2005
    Assignee: KOSAN Biosciences, Inc.
    Inventors: Gary Ashley, Robert L. Arslanian, John Carney, Brian Metcalf, Li Tang
  • Epothilone compounds and methods for making and using the same
    Patent number: 6589968
    Abstract: This present invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: July 8, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Robert L. Arslanian, John R. Carney, Brian Metcalf
  • Production of polyketides
    Publication number: 20030073205
    Abstract: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
    Type: Application
    Filed: September 19, 2001
    Publication date: April 17, 2003
    Inventors: Robert L. Arslanian, Gary Ashley, Scott Frykman, Bryan Julien, Leonard Katz, Chaitan Khosla, Janice Lau, Peter J. Licari, Rika Regentin, Daniel Santi, Li Tang
  • Epothilone derivatives and methods for making and using the same
    Publication number: 20030045711
    Abstract: This invention relates to compounds of formula (I) 1
    Type: Application
    Filed: April 2, 2002
    Publication date: March 6, 2003
    Inventors: Gary Ashley, Robert L. Arslanian, John Carney, Brian Metcalf, Li Tang
  • Epothilone compounds and methods for making and using the same
    Publication number: 20020156110
    Abstract: The present invention relates to compounds of the formula: 1
    Type: Application
    Filed: April 3, 2001
    Publication date: October 24, 2002
    Inventors: Robert L. Arslanian, John R. Carney, Brian Metcalf