Patents by Inventor Robert L. Coffman

Robert L. Coffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intrapulmonary administration of polynucleotide toll-like receptor 9 agonists for treating cancer of the lung
    Patent number: 9993495
    Abstract: The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 12, 2018
    Assignee: Dynavax Technologies Corporation
    Inventors: Cristiana Guiducci, Robert L. Coffman
  • Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof
    Patent number: 9950064
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: April 24, 2018
    Assignee: Dynavax Technologies Corporation
    Inventors: Gary S. Ott, Robert J. Milley, Robert L. Coffman, Radwan R Kiwan, Holger Kanzler
  • INTRAPULMONARY ADMINISTRATION OF POLYNUCLEOTIDE TOLL-LIKE RECEPTOR 9 AGONISTS FOR TREATING CANCER OF THE LUNG
    Publication number: 20160346312
    Abstract: The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
    Type: Application
    Filed: May 23, 2016
    Publication date: December 1, 2016
    Inventors: Cristiana GUIDUCCI, Robert L. COFFMAN
  • Methods and compositions for inhibition of immune responses and autoimmunity
    Patent number: 9476053
    Abstract: The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: October 25, 2016
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Tracy Matray, Cristiana Guiducci
  • BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF
    Publication number: 20160213774
    Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 28, 2016
    Inventors: Gary S. Ott, Robert J. Milley, Robert L. Coffman, Radwan Kiwan, Holger Kanzler
  • Methods of treatment using TLR7 and/or TLR9 inhibitors
    Patent number: 9347064
    Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: May 24, 2016
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Cristiana Guiducci
  • Long term disease modification using immunostimulatory oligonucleotides
    Patent number: 9333254
    Abstract: The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 10, 2016
    Assignee: Dynavax Technologies Corporation
    Inventors: Edith M. Hessel, Robert L. Coffman
  • TLR8 TRANSGENIC ANIMALS
    Publication number: 20160003807
    Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.
    Type: Application
    Filed: April 23, 2015
    Publication date: January 7, 2016
    Applicant: DYNAVAX TECHNOLOGIES CORPORATION
    Inventors: Franck BARRAT, Robert L. COFFMAN, Cristiana GUIDUCCI
  • METHODS AND COMPOSITIONS FOR INHIBITION OF IMMUNE RESPONSES AND AUTOIMMUNITY
    Publication number: 20150275216
    Abstract: The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
    Type: Application
    Filed: February 3, 2015
    Publication date: October 1, 2015
    Inventors: Franck BARRAT, Robert L. COFFMAN, Tracy MATRAY, Cristiana GUIDUCCI
  • METHODS OF TREATMENT USING TLR7 AND/OR TLR9 INHIBITORS
    Publication number: 20150203850
    Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
    Type: Application
    Filed: November 25, 2014
    Publication date: July 23, 2015
    Inventors: Franck BARRAT, Robert L. COFFMAN, Cristiana GUIDUCCI
  • Transgenic mice expressing human toll-like receptor 8
    Patent number: 9063123
    Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic s and methods of use thereof.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: June 23, 2015
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Cristiana Guiducci
  • Methods and compositions for inhibition of immune responses and autoimmunity
    Patent number: 8962579
    Abstract: The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: February 24, 2015
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Tracy Matray, Cristiana Guiducci
  • METHODS AND COMPOSITIONS FOR INHIBITION OF INNATE IMMUNE RESPONSES AND AUTOIMMUNITY
    Publication number: 20150050296
    Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.
    Type: Application
    Filed: June 23, 2014
    Publication date: February 19, 2015
    Inventors: Franck BARRAT, Robert L. COFFMAN
  • Methods of treatment using TLR7 and/or TLR9 inhibitors
    Patent number: 8940310
    Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: January 27, 2015
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Cristiana Guiducci
  • LONG TERM DISEASE MODIFICATION USING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
    Publication number: 20150024007
    Abstract: The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
    Type: Application
    Filed: July 18, 2014
    Publication date: January 22, 2015
    Inventors: Edith M. HESSEL, Robert L. Coffman
  • Long term disease modification using immunostimulatory oligonucleotides
    Patent number: 8815817
    Abstract: The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: August 26, 2014
    Assignee: Dynavax Technologies Corporation
    Inventors: Edith M. Hessel, Robert L. Coffman
  • Methods and compositions for inhibition of innate immune responses and autoimmunity
    Patent number: 8759305
    Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: June 24, 2014
    Assignee: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman
  • METHODS OF TREATMENT USING TLR7 AND/OR TLR9 INHIBITORS
    Publication number: 20130156814
    Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
    Type: Application
    Filed: June 16, 2011
    Publication date: June 20, 2013
    Applicant: Dynavax Technologies Corporation
    Inventors: Franck Barrat, Robert L. Coffman, Cristiana Guiducci
  • TLR8 TRANSGENIC ANIMALS
    Publication number: 20120252051
    Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.
    Type: Application
    Filed: March 29, 2012
    Publication date: October 4, 2012
    Applicant: DYNAVAX TECHNOLOGIES CORPORATION
    Inventors: Franck Barrat, Robert L. Coffman, Cristiana Guiducci
  • Long term disease modification using immunostimulatory oligonucleotides
    Patent number: 8252757
    Abstract: The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: August 28, 2012
    Assignee: Dynavax Technologies Corporation
    Inventors: Edith M. Hessel, Robert L. Coffman