Patents by Inventor Robert L. Dow

Robert L. Dow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5843972
    Abstract: The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs thereof, depicted below, which are .beta.-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of .beta..sub.3 -adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals and poultry. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Y and Z are as defined in the specification.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: December 1, 1998
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Stephen W. Wright
  • Patent number: 5767133
    Abstract: The present invention relates to compounds of the formula ##STR1## having utility as hypoglycemic and antiobesity agents, methods for their use and pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving lean meat to fat ratio in edible animals, i.e. ungulate animals and poultry.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: June 16, 1998
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Stephen W. Wright
  • Patent number: 5723844
    Abstract: A system for using a ferrite element to convert RF energy into heat consists only of the ferrite element, an RF generator and a cable connecting the ferrite element to the RF generator. No external impedance matching mechanism is needed, and the preferred form of the ferrite has a Curie temperature in excess of 150.degree. C., and has a lower cutoff frequency of about 10 KHz. The specific best mode ferrite element includes a formulation of MnO.sub.0.45 Zn.sub.0.3 FeO.sub.0.25 Fe.sub.2 O.sub.4. One use of the circuit is in the mining industry.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: March 3, 1998
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 5639757
    Abstract: Certain 4-aminopyrrolo[2,3-d]pyrimidine compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: June 17, 1997
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Kevin Koch
  • Patent number: 5627200
    Abstract: This invention relates to methods for treating intestinal motility disorders, intestinal ulcerations, including inflammatory bowel disease, ulcerative colitis, Crohn's disease and proctitis, and gastrointestinal ulcerations, depression, prostate disease and dyslipidemia by administering a .beta..sub.3 -adrenoceptor antagonist or agonist.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: May 6, 1997
    Assignee: Pfizer Inc
    Inventors: David K. Kreutter, Robert L. Dow
  • Patent number: 5593997
    Abstract: Certain 4-aminopyrazolo[3,4-d]pyrimidine compounds, and their pharmaceutically-acceptable salts and prodrugs, are inhibitors of tyrosine kinase enzymes and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: January 14, 1997
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Kevin Koch, Gary R. Schulte
  • Patent number: 5498621
    Abstract: Compounds of the formulae ##STR1## where R is cycloalkyl or aryl; R.sub.1 is alkyl, X is O or C.dbd.O; A is O or S; and B is N or CH are useful as hypoglycemic agents.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: March 12, 1996
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Bernard Hulin, David A. Clark
  • Patent number: 5457237
    Abstract: Certain dihydroxyindanone compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: October 10, 1995
    Assignee: Pfizer Inc.
    Inventor: Robert L. Dow
  • Patent number: 5355800
    Abstract: The precision ignition device disclosed in U.S. Pat. No. 4,708,060 is combined with the device disclosed in U.S. Pat. No. 5,036,768, and U.S. Ser. No. 07/584,045 to provide accurate control over the ignition of an EED while also protecting that EED from inadvertent firing caused by exposure to extraneous electricity, such as RF energy or electrostatic energy. The combined device can be connected to a source of power and/or to an external sequential timer for further control over the firing process. A method of fabricating the means for protecting the EED from inadvertent extraneous electricity induced firing is also disclosed.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: October 18, 1994
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 5326905
    Abstract: Certain benzylphosphonic acid compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: July 5, 1994
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Steven W. Goldstein
  • Patent number: 5279225
    Abstract: A device for preventing an electroexplosive device from inadvertent RF energy or electrostatic energy induced firing, even if that device is exposed to high RF power levels or high RF frequencies or to high electrostatic potentials, includes an impedance element in the firing input line between a source of dc power and a bridgewire which has an impedance that exceeds an impedance between the input leads and ground. When RF energy levels and frequencies exceed certain values, arcing occurs between one input lead and the other or between the input leads and a conductive case to cause energy to flow to the conductive case instead of to the bridgewire. One form of the device includes a Ferrite element in electrical and thermal contact with both of the firing input leads and with the thermally and electrically conductive case. The Ferrite element has a dc resistance in excess of the dc resistance of the bridgewire so short circuiting the firing current does not occur.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: January 18, 1994
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 5243911
    Abstract: A device for preventing energy associated with nearby lightning strikes, electrostatic energy, and/or RF energy from damaging or inadvertently operating or actuating electronic equipment, such as an EED electrical initiation element, includes a bipartite faraday shield. One wall of the bipartite faraday shield is formed of a ferrite element such as disclosed in U.S. Pat. No. 5,036,768 and application Ser. No. 07/584,045. In some cases, the ferrite element can be doped with calcium oxide. The preferred doping range is between 1 and 20 ppm. A specific embodiment of the bipartite faraday shield includes an open-ended metal case with the ferrite device closing the open end of the case.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: September 14, 1993
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 5197468
    Abstract: An implantable prosthesis, such as an artificial cardiac pacer, or the like, is protected from misoperation caused by RF energy and/or electrostatic energy incident thereon by a protective device attached to the lead wire connecting the device to tissue stimulating electrodes or other such electrodes mounted in a patient. The protective device is the device disclosed in U.S. patent application Ser. Nos. 07/794,125, 07/584,045 and 07/866,512. The protective device includes a Ferrite body electrically and thermally connected to the lead wire and to a ground element, such as the housing for the prosthetic device. The Ferrite body, in conjunction with the lead and the ground element, has an impedance that exceeds the impedance established between the lead wire and ground when the device is exposed to RF energy.
    Type: Grant
    Filed: May 27, 1992
    Date of Patent: March 30, 1993
    Inventors: Paul W. Proctor, Robert L. Dow
  • Patent number: 5139283
    Abstract: This invention discloses an adjustable and foldable ski pole which comprises two pole sections hinged together to be foldable into a uniquely convenient compact structure that can be carried safely and easily and can be easily stored in a car, boot bag or its own nylon bag while being adjustable for users of different heights. The ski pole has an especially robust construction to be durable and suitable for professional use. Further benefits are provided for retailers and ski rental agencies.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: August 18, 1992
    Inventors: Robert L. Dow, Philip S. Kornblum, Jay S. Lief
  • Patent number: 5115633
    Abstract: A low-cost, lightweight mobile gas turbine capable of rotating in excess of ne hundred thousand RPM is coupled to a centrifugal air compressor which supplies high volume airflow to a diesel fueled combustion chamber for supplying hot gas to the turbine. Three energy outputs are obtained in the form of pressurized airflow, hot gas flow and large volumes of directed ambient air. The hardware components are essentially state-of-the-art, but their combination for use in multi-purpose military combat operations has not heretofore been known. Such uses include smoke generation, dissemination of infre-red and radar absorbant clouds, decontamination of large masses, hot water supply and air pressure source for mechanics tool operation.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: May 26, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: David B. Priser, Robert L. Dow
  • Patent number: 5036768
    Abstract: An attenuator for dissipating electromagnetic energy and equalizing electrostatic energy is formed of a lossy ferrite material having an electrical resistance in a range of about 3,000 to 50,000 ohms. A conductor passes through the material and thence to a bridgewire to supply a firing charge to heat the bridgewire. In one embodiment of the invention, the attenuator is mounted within an electrically and thermally conductive housing, which will dissipate heat and equalize electromagnetic energy which may be induced in the conductor. A capacitive effect may be imparted by the orientation of the conductor as it passes through the ferrite. The capacitive effect is produced in winding the conductor parallel to the metal housing, and parallel to any other conductor passing through the ferrite. In the preferred form, the conductors are wound through the ferrite in a spiral pattern parallel to the conductor housing.
    Type: Grant
    Filed: February 13, 1990
    Date of Patent: August 6, 1991
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 4848233
    Abstract: An RF attenuator for attenuating RF signals in a lead particularly for prcting against unintentional detonation of electrically initiated ammunition is presented. A firing lead is embedded in a body of ferrite material. The firing lead is formed in a planar spiral configuration with reversals of direction.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: July 18, 1989
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Robert L. Dow, Paul W. Proctor
  • Patent number: 4779511
    Abstract: A disposable EOD dearmer (10) includes an propellant charge (36) permanen affixed to a tubular body (14) for propelling a dearmer slug (40) against a dud casing (12). The pressure versus time characteristic (60, 70) of the charge can be selected to provide a preselected velocity for the slug at impact with the casing, and the initial position (60', 70") of the slug can be selected to provide a preselected delay between ignition of the charge and impact between the slug and the casing.
    Type: Grant
    Filed: July 9, 1985
    Date of Patent: October 25, 1988
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul W. Proctor, Robert L. Dow
  • Patent number: 4601761
    Abstract: A self contained jet perforator torch (10) for defining large holes (H) in workpiece (W) such as a large bomb, includes a plurality of ports (68) fluidically connecting a combustion chamber with a slot-like chamber (62). The ports and the slot-like chamber extend at an angle with respect to the longitudinal centerline of the torch whereby fluid exiting the torch contacts a workpiece at an angle (I) with a normal (N) extending from the workpiece.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: July 22, 1986
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul W. Proctor, Robert L. Dow
  • Patent number: 4432816
    Abstract: A composition for a cutting touch for quickly breaching a munition casing d burning out the energetic material therein consists essentially from about 15 to about 20 weight percent of aluminum, from about 5 to about 10 weight percent of the copolymer of vinylidene fluoride and hexafluoropropylene, up to about 0.6 weight percent of graphite and the remainder of ferric oxide.
    Type: Grant
    Filed: November 9, 1982
    Date of Patent: February 21, 1984
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Katherine L. Kennedy, Paul W. Proctor, Robert L. Dow