Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.

Abstract: A garment for detecting radiation washout (e.g., radioactivity concentrations) in organs includes a covering that wraps around and is secured to the body. The covering permits positron emission tomography-computed tomography (PET/CT) imaging of the body through the covering. The garment includes guides formed from a material that is visible in a computed tomography (CT) image of the garment, such that the guides are visible in CT images of user organs that the garment overlies. A plurality of radiation detectors are attached to the covering in a configuration customized for the body. A wiring system connects the plurality of radiation detectors to a power and data control system that is configured to transmit data from the garment to a remote service provider.

Abstract: A harness has a harness body, a belt strap, two leg straps, a small opening to slidably accommodate an aeration tube, and a larger opening to accommodate a catheter sleeve. The catheter sleeve has a length of cylindrical body which has a tapered end and a flexible end that extends though the harness body about a half inch. The one end of the aeration tube extends into the catheter sleeve cylindrical body through the small opening to provide aeration into the catheter sleeve, and the other end extends slidably through the small opening in the harness body.

Abstract: A mobile device is provided. The mobile device includes an activity sensor for generating data, a channel controller configured to determine the user presence based on the data obtained through the activity sensor, and a communication interface for communicating with an external network. The channel controller is configured to block or disable the communication between a source on the mobile device and the external network when the channel controller determines a lack of the user presence for a predetermined time.

Abstract: A mobile device is provided. The mobile device includes an activity sensor for generating data, a channel controller configured to determine the user presence based on the data obtained through the activity sensor, and a communication interface for communicating with an external network. The channel controller is configured to block or disable the communication between a source on the mobile device and the external network when the channel controller determines a lack of the user presence for a predetermined time.

Abstract: Novel viruses capable of infecting fall armyworms (Spodoptera frugiperda) were isolated and sequences of the viruses were determined. The viruses were shown to be capable of being used as a biopesticide to control populations of fall armyworm.

Abstract: Novel insect toxins are disclosed for use in pesticidal compositions and methods. According to the invention basement membrane degrading proteases are identified which are capable of acting as insecticidal agents. Polynucleotides are provided which include expression constructs for the expression of the recombinant insecticidal proteases of the invention as recombinant insect pathogens, as well as transgenic plants with a substantial degree of insect resistance.

Abstract: Novel insect toxins are disclosed for use in pesticidal compositions and methods. According to the invention basement membrane degrading proteases are identified which are capable of acting as insecticidal agents. Polynucleotides are provided which include expression constructs for the expression of the recombinant insecticidal proteases of the invention as recombinant insect pathogens, as well as transgenic plants with a substantial degree of insect resistance.

Abstract: A magnetic tape head actuator assembly has a stepper motor having a threaded output shaft and a bracket for supporting a tape head assembly. The bracket includes a pair of outwardly extending flanges. The flanges each have a bore, whereby the bores are axially aligned and dimensioned to accept the output shaft therethrough. The bracket further has an integral platform portion oriented normal to the threaded output shaft for mounting a tape head assembly. A threaded split nut positioned intermediate the bores is rigidly attached to the bracket and engages the threaded output shaft for movement of the bracket back and forth along the shaft. The nut further has an annular groove encircling its outer perimeter, wherein a circular spring positioned therein provides an inwardly directed compressive force on the nut.