Patents by Inventor Robert L. Hudkins

Robert L. Hudkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused pyrrolocarbazoles
    Patent number: 7514440
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: April 7, 2009
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Dandu R. Reddy, Ming Tao, Theodore L. Underiner, Allison L. Zulli
  • Method of radio-sensitizing tumors using a radio-sensitizing agent
    Publication number: 20080146556
    Abstract: The present invention relates to a method of treating cancer using PARP inhibitors as radio-sensitization agents of tumors. Specifically the present invention relates to a method of radio-sensitization of tumors using a compound of Formula (I) or a pharmaceutically acceptable salt form thereof. The present invention also relates to a pharmaceutical compositions of PARP inhibitors for radiosensitizing tumors.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 19, 2008
    Applicant: Cephalon, Inc.
    Inventors: James L. Diebold, Robert L. Hudkins, Sheila J. Miknyoczki, Bruce Ruggeri
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 7291732
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: November 6, 2007
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Cyclic substituted fused pyrrolocarbazoles and isoindolones
    Patent number: 7288650
    Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: October 30, 2007
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
  • Fused pyrrolocarbazoles
    Patent number: 7241779
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: July 10, 2007
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Ming Tao, Theodore L. Underiner
  • Selected fused pyrrolocarbazoles
    Patent number: 7230026
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: June 12, 2007
    Assignee: Cephalon, Inc.
    Inventors: Diane E. Gingrich, Robert L. Hudkins
  • Fused pyrrolocarbazoles
    Patent number: 7169802
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 30, 2007
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Diane E. Gingrich, Ming Tao, Nadine C. Becknell, James L. Diebold, Theodore L. Underiner
  • Multicyclic compounds and the use thereof
    Patent number: 7122679
    Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: October 17, 2006
    Assignee: Cephalon, Inc.
    Inventors: Mark A. Ator, Ron Bihovsky, Sankar Chatterjee, Derek Dunn, Robert L. Hudkins
  • Selected fused pyrrolocarbazoles
    Patent number: 7115613
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: October 3, 2006
    Assignee: Cephalon, Inc.
    Inventors: Diane E. Gingrich, Robert L. Hudkins
  • Cyclic substituted fused pyrrolocarbazoles and isoindolones
    Patent number: 7074793
    Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: July 11, 2006
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
  • Methods for the treatment and prevention of pain
    Patent number: 7018999
    Abstract: Novel methods for the treatment and/or prevention of pain are presented. The methods may comprise administering to a subject in need thereof an effective amount of a stress-activated protein kinase inhibitor. Preferred compounds for use in the methods include fused pyrrolocarbazole compounds.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: March 28, 2006
    Assignee: Cephalon, Inc.
    Inventors: Lisa D. Aimone, Robert L. Hudkins, Matthew S. Miller
  • Selected derivatives of K-252a
    Patent number: 6875865
    Abstract: Disclosed herein are selected indolocarbazole derivatives which are represented by the general formula: The compounds are useful for enhancing the function and/or survival of a trophic factor responsive cell. They inhibit interleukin-2 production and have immunosuppressive activity.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: April 5, 2005
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, John P. Mallamo, Masami Hamano, Rieko Tanaka, Chikara Murakata
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 6872746
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: March 29, 2005
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Cyclic substituted fused pyrrolocarbazoles and isoindolones
    Patent number: 6841567
    Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: January 11, 2005
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
  • Cyclic substituted fused pyrrolocarbazoles and isoindolones
    Publication number: 20040186157
    Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.
    Type: Application
    Filed: January 12, 2004
    Publication date: September 23, 2004
    Applicant: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Publication number: 20030216419
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Application
    Filed: April 24, 2003
    Publication date: November 20, 2003
    Applicant: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Selected fused pyrrolocarbazoles
    Publication number: 20030203957
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 30, 2003
    Applicant: Cephalon, Inc.
    Inventors: Diane E. Gingrich, Robert L. Hudkins
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 6635669
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: October 21, 2003
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Selected fused pyrrolocarbazoles
    Patent number: 6630500
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: October 7, 2003
    Assignee: Cephalon, Inc.
    Inventors: Diane E. Gingrich, Robert L. Hudkins
  • Selected soluble esters of hydroxyl-containing indolocarbazoles
    Patent number: RE38332
    Abstract: Esters of hydroxyl-containing indolocarbazoles and acids containing selected solubilizing groups are provided. Compositions including the indolocarbazole esters and methods for the use of the indolocarbazole esters are also provided.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: November 25, 2003
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: John P. Mallamo, Robert L. Hudkins