Patents by Inventor Robert L. Jilka

Robert L. Jilka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 10676718
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 9, 2020
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS
    Publication number: 20180127720
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 10, 2018
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 9873862
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: January 23, 2018
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS
    Publication number: 20150210983
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated stale in the absence of feeder cells and applications of the same.
    Type: Application
    Filed: January 14, 2015
    Publication date: July 30, 2015
    Inventors: Xiao-Dong CHEN, Robert L. Jilka
  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 8961955
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: February 24, 2015
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as Represented by the Department of Veterans Affair
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 8388947
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 5, 2013
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS
    Publication number: 20120064046
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Application
    Filed: November 16, 2011
    Publication date: March 15, 2012
    Applicants: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • Maintenance and propagation of mesenchymal stem cells
    Patent number: 8084023
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: December 27, 2011
    Assignees: The Board of Trustees of The University of Arkansas, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • Maintenance and Propagation of Mesenchymal Stem Cells
    Publication number: 20080175816
    Abstract: Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 24, 2008
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Xiao-Dong Chen, Robert L. Jilka
  • In vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
    Publication number: 20040248078
    Abstract: The present invention demonstrates that glucocorticoid-induced bone disease is due to changes in the birth and death rate of bone cells using a murine model of glucocorticoid excess as well as bone biopsy specimens obtained from patients with glucocorticoid-induced osteoporosis. This invention demonstrates that glucocorticoid administration increases apoptosis of mature osteoblasts and osteocytes and decreases bone formation rate and bone mineral density accompanied by defective osteoblastogenesis and osteoclastogenesis in the bone marrow.
    Type: Application
    Filed: December 8, 2003
    Publication date: December 9, 2004
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Stavros C. Manolagas, Robert L. Jilka, Robert S. Weinstein, Teresita Bellido
  • Methods of screening for apoptosis-controlling agents for bone anabolic therapies and uses thereof
    Publication number: 20040224884
    Abstract: The invention as disclosed provides a method to increase bone mass without compromising bone strength or quality, through the administration to a host of a compound that binds to the estrogen or androgen receptor without causing hormonal transcriptional activation.
    Type: Application
    Filed: December 22, 2003
    Publication date: November 11, 2004
    Inventors: Stavros C. Manolagas, Robert L. Jilka, Robert S. Weinstein, Teresita Bellido
  • Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
    Patent number: 6660468
    Abstract: The present invention demonstrates that glucocorticoid-induced bone disease is due to changes in the birth and death rate of bone cells using a murine model of glucocorticoid excess as well as bone biopsy specimens obtained from patients with glucocorticoid-induced osteoporosis. This invention demonstrates that glucocorticoid administration increases apoptosis of mature osteoblasts and osteocytes and decreases bone formation rate and bone mineral density accompanied by defective osteoblastogenesis and osteoclastogenesis in the bone marrow.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: December 9, 2003
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Stavros C. Manolagas, Robert L. Jilka, Robert S. Weinstein, Teresita Bellido