Patents by Inventor Robert L. Moritz

Robert L. Moritz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to obtain unbiased identification of interaction of test compounds with the proteome
    Patent number: 11024492
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: June 1, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • Method to obtain unbiased identification of interaction of test compounds with the proteome
    Patent number: 10978281
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: April 13, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME
    Publication number: 20200251319
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 6, 2020
    Applicant: Institute for Systems Biology
    Inventors: Robert L. MORITZ, Samuel BADER, Ulrike KUSEBAUCH
  • Point of care assays to detect the status of tuberculosis infection
    Patent number: 9726667
    Abstract: Point of care methods to detect the probability or status of tuberculosis infection in individuals by determining presence or absence of one or more peptide of SEQ ID NOS:1-22 in a biological fluid of a subject are described. These methods may be assays based on affinity reagents specifically reactive with these peptides.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: August 8, 2017
    Assignee: INSTITUTE FOR SYSTEMS BIOLOGY
    Inventors: Robert L. Moritz, Mark Sartain, Zdenek Spacil, Ulrike Kusebauch, David Campbell
  • METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME
    Publication number: 20170010229
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 12, 2017
    Applicant: Institute for Systems Biology
    Inventors: Robert L. MORITZ, Samuel BADER, Ulrike KUSEBAUCH
  • POINT OF CARE ASSAYS TO DETECT THE STATUS OF TUBERCULOSIS INFECTION
    Publication number: 20150253324
    Abstract: Point of care methods to detect the probability or status of tuberculosis infection in individuals by determining presence or absence of one or more peptide of SEQ ID NOS:1-22 in a biological fluid of a subject are described. These methods may be assays based on affinity reagents specifically reactive with these peptides.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Inventors: Robert L. MORITZ, Mark SARTAIN, Zdenek SPACIL, Ulrike KUSEBAUCH, David CAMPBELL
  • Methods and apparatus for use in sequential chemical reactions
    Patent number: 5605839
    Abstract: This invention relates to methods and apparatus for carrying out chemical reactions between a plurality of reactants and in particular it is amenable to micro or nano scale operation and to the sequential chemical reactions required during such processes as construction or sequencing of proteins, oligonucleotides and polysaccharides. The present invention further relates to a capillary liquid chromatography system for high-sensitivity component separation and microsequencing for use in association with the methods and apparatus herein described.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: February 25, 1997
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Richard J. Simpson, Antony W. Burgess, Robert L. Moritz