Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: A transportation rack includes a frame having a base configured for resting on a surface and first and second track members and positioned parallel to each other and extending upwardly away from the base between respective lower ends and upper ends, a first support member extending between the track members and respectively slidably connected with each of the first and second track members at opposite lateral ends of the first support member, and a second support member extending between the first and second track members and respectively slidably connected with each of the first and second track members at opposite lateral ends of the second support member, the second support member being coupled with the first support member by a flexible connection.

Abstract: An adjustable pillow includes an inner cover defining a pocket and removable stuffing within the pocket. A related method of manufacture includes forming the inner cover having a pocket from a sheet and placing stuffing within the pocket.

Abstract: An adjustable pillow includes an inner cover defining a pocket and removable stuffing within the pocket. A related method of manufacture includes forming the inner cover having a pocket from a sheet and placing stuffing within the pocket.

Abstract: A handbag accessory device that removably attaches to the strap of a purse, handbag or similar article, and enables the user to hang hangers from the strap, as well as articles such as clothing, etc. that may be hung from the hangers, all without damaging the user's purse or handbag. The device is generally comprised of an elongated strap and a fastener, and enables a user to free up his or her hands to perform other tasks such as answering the phone, browsing other clothing racks, checking price tags, etc. Finally, the device can be removed from the purse or handbag when not in use to as to not detract from the overall appearance of the purse or handbag.

Abstract: Data for a transaction is modeled by receiving a source set of data. The source set of data comprises data representing a plurality of transactions stored in a source transaction database. An estimation model for modeling data for a transaction is received. A mapping between the source set of data and a model parameter database is received. The model parameter database comprises a plurality of model parameters for the estimation model. The parameters extracted from the model parameter database and the source set of data in a Bayesian framework are combined using a parameter estimation engine to obtain an updated set of model parameters. The updated set of model parameters is stored in the model parameter database.

Abstract: A price sensitivity score is calculated for a prospect by obtaining data associated with a prospect. A scoring function is determined (which is a function of one or more scoreable variables) based at least in part on training data set. A price sensitivity score is calculated by evaluating the scoring function using the data associated with the prospect.

Abstract: The present invention provides a dynamic pricing system that generates pricing recommendations for each product in each market. In particular, the system normalizes historic pricing and sales data, and then analyzes this historic data using parameters describing the user's business objectives to produce a pricing list to achieve these objectives. The system uses historical market data to forecast expected sales according to a market segment, product type, and a range of future dates and to determine the effects of price changes on the forecasted future sales. The system further calculates unit costs for the product. The system then estimates profits from sales at different prices by using the sales forecasts, adjusting these sales forecasts for changes in prices, and the costs determinations. The system optionally optimizes prices given current and projected inventory constraints and generates alerts notices according to pre-set conditions.

Abstract: The present invention provides an event revenue management system that calculates event pricing to manage revenue and to maximize profit from the event. In particular, the system uses event parameters, including timing, resource, and discount categories, and initializes forecasting parameters. The system aggregates historical data using the forecasting parameters to generate initial forecast statistics, taking into account the event parameters. It then forecasts demand by updating the initial forecast statistics based on current data and optimizes pricing and availability of the event based on the forecasted demand.

Abstract: The present invention provides an event revenue management system that calculates event pricing to manage revenue and to maximize profit from the event. In particular, the system uses event parameters, including timing, resource, and discount categories, and initializes forecasting parameters. The system aggregates historical data using the forecasting parameters to generate initial forecast statistics, taking into account the event parameters. It then forecasts demand by updating the initial forecast statistics based on current data and optimizes pricing and availability of the event based on the forecasted demand.

Abstract: The present invention provides a dynamic pricing system that generates pricing recommendations for each product in each market. In particular, the system normalizes historic pricing and sales data, and then analyzes this historic data using parameters describing the user's business objectives to produce a pricing list to achieve these objectives. The system uses historical market data to forecast expected sales according to a market segment, product type, and a range of future dates and to determine the effects of price changes on the forecasted future sales. The system further calculates unit costs for the product. The system then estimates profits from sales at different prices by using the sales forecasts, adjusting these sales forecasts for changes in prices, and the costs determinations. The system optionally optimizes prices given current and projected inventory constraints and generates alerts notices according to pre-set conditions.

Abstract: A method and system for determining marginal values for perishable resources expiring at a future time, for example, an airline seat, hotel room night, rental car day or the like, for use in a perishable resource revenue management system. Data for the perishable resources and composite resources is loaded from the perishable resource revenue management system into the marginal value system. Internal data structures are constructed for linking each of the perishable resources to their associated composite resources and for linking each of the composite resources to their associated perishable resources. The marginal values for the perishable resources are determined using a continuous optimization function using interdependencies among the perishable resources and the composite resources in the internal data structures. The marginal values are stored from the marginal value system into the perishable resource revenue management system.

Abstract: An entangled fibre nonwoven fabric containing irregular sized apertures in a random irregular nonrepeating pattern in disclosed. In the method of the invention, a fibrous web is caused to be displaced out of registry with the forming member between fluid impacts by columnar jets of water.

Abstract: Apparatus for applying rotational pressure to one or more selected parts of the body of a patient includes at least two separate casts placed about portions of the patient's body so as to hold such portions against substantial rotation relative to such casts and interconnections between the separate casts adapted to hold the casts at selected angles of rotation to one another to thereby put rotational pressure on the selected parts of the body. A method for applying rotational pressure to one or more selected parts of the body includes the steps of casting portions of the body, rotating the casts with respect to one another, and locking the casts together in rotated position to thereby place rotational pressure on the selected portion of the body.

Abstract: A printing machine for applying marks at specified locations on a moving web. The machine has specific utility in check or document signing applications where a number of forms are successively signed by a signature stamp. In accordance with a preferred embodiment of the invention the machine has one motor for driving a web of paper to a print station and a second motor for activating a stamp by rotating the stamp into contact with the web. The motors are individually energizable under control of a programmable controller. By coordinating the times and duration of motor energization the spacing between successive marks can be varied over a wide range of values. The flexibility in print spacing allows the printing machine to be used in conjunction with the processing stations such as word processing and the like.

Abstract: A combination instrument, for use in making biomechanical measurements of the limbs, joints, and appendages of a human body, comprises a scaled straightedge adapted to slidably receive thereon a set of mutually cooperative caliper arms which, themselves, slidably carry body-contacting pads for adjustable placement relative to each other longitudinally of the caliper arms and relative to body irregularities, one of which arms carries a gravity meter for indicating angle measurements, the straightedge being further adapted to pivotally receive at one end thereof a protractor device for rotational movement relative to the straightedge and the caliper arms.