Patents by Inventor Robert L. Shepard

Robert L. Shepard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating resistant tumors
    Patent number: 6124311
    Abstract: The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: September 26, 2000
    Assignee: Eli Lilly and Company
    Inventors: Srinivasan Chandrasekhar, Anne H. Dantzig, Robert L. Shepard, James J. Starling, Mark A. Winter
  • Methods for reversing multidrug resistance
    Patent number: 6121292
    Abstract: The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: September 19, 2000
    Assignee: Eli Lilly and Company
    Inventors: Srinivasan Chandrasekhar, Anne H. Dantzig, Robert L. Shepard, James J. Starling, Mark A. Winter
  • Dual-mode self-validating resistance/Johnson noise thermometer system
    Patent number: 5228780
    Abstract: A dual-mode Johnson noise and DC resistance thermometer capable of use in control systems where prompt indications of temperature changes and long term accuracy are needed. A resistance-inductance-capacitance (RLC) tuned circuit produces a continuous voltage signal for Johnson noise temperature measurement. The RLC circuit provides a mean-squared noise voltage that depends only on the capacitance used and the temperature of the sensor. The sensor has four leads for simultaneous coupling to a noise signal processor and to a DC resistance signal processor.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: July 20, 1993
    Assignee: Martin Marietta Energy Systems, Inc.
    Inventors: Robert L. Shepard, Theron V. Blalock, Michael J. Roberts
  • Optical Johnson noise thermometry
    Patent number: 5098197
    Abstract: Method and device for direct, non-contact temperature measure of a body. A laser beam is reflected from the surface of the body and detected along with the Planck radiation. The detected signal is analyzed using signal correlation technique to generate an output signal proportional to the Johnson noise introduced into the reflected laser beam as a direct measure of the absolute temperature of the body.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: March 24, 1992
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Robert L. Shepard, Theron V. Blalock, Michael J. Roberts, Lonnie C. Maxey