Patents by Inventor Robert L. Webb

Robert L. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-t-butyl-androst-3,5-diene-17.beta.-carboxamide-3-carboxylic acid polymorph A
    Patent number: 5596109
    Abstract: The invention describes a process for the preparation of the polymorph A form of a compound having the structure ##STR1## which involves triturating, crystallizing, or precipitating crude N-t-butyl-androst-3,5-diene-17.beta.-carboxamide-3-carboxylic acid from an ethyl acetate or t-butyl methyl ether solvent, followed by isolation of the polymorph A.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: January 21, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Neil H. Baine, Neville L. Holder, Donald N. Klein, Robert L. Webb, Gary E. Zuber
  • 17-.alpha.-acyl steroids which inhibit 5-.alpha.-reductase
    Patent number: 5561124
    Abstract: The invention relates to substituted 17.alpha.-acyl steroidal 5.alpha.-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for reducing prostate size and treating prostate adenocarcinoma. Further, the invention describes a process for making these compounds by heating the corresponding substituted 17.beta.-acyl steroid in a solvent, such as ethylene glycol or dimethyl sulfoxide (DMSO), in a base, such as sodium or potassium hydroxide.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: October 1, 1996
    Inventor: Robert L. Webb
  • Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles
    Patent number: 4321393
    Abstract: A method of preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles comprising reacting N-cyanodiphenoxyiminocarbonate with an o-amino or o-hydroxy aniline.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventors: Clifford S. Labaw, Robert L. Webb
  • Preparation of 2-thiophenecarbonyl chloride
    Patent number: 4321399
    Abstract: Thiophenecarbonyl chloride is produced in good yields by the direct acylation of thiophene in the presence of aluminum chloride with control of temperature and concentration.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventors: Stella S. Jones, Christine B. Ogston, Robert L. Webb
  • N-Phenyl-N'-cyano-O-phenylisoureas
    Patent number: 4285878
    Abstract: N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benzoxazole compounds having anthelmintic activity.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventors: Clifford S. Labaw, Robert L. Webb
  • Intermediates for preparing hydroxyphenylpyridazinones
    Patent number: 4272440
    Abstract: 5-(5'-Halo-2'-methoxyphenyl)-3,4-dihalo-2(5H)-furanones are prepared by a Friedel-Crafts reaction using a p-haloanisole and a mucohalic acid in the presence of aluminum chloride. They are used as chemical intermediates for preparing hydroxyphenylpyridazinones.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: June 9, 1981
    Assignee: SmithKline Corporation
    Inventors: Angelina J. Duggan, Robert L. Webb
  • Imidazolemethylphosphonium salts
    Patent number: 4267337
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.
    Type: Grant
    Filed: December 12, 1979
    Date of Patent: May 12, 1981
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Process for preparing 4-substituted imidazole compounds
    Patent number: 4215217
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: July 29, 1980
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
    Patent number: 4166061
    Abstract: A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.
    Type: Grant
    Filed: November 2, 1977
    Date of Patent: August 28, 1979
    Assignee: SmithKline Corporation
    Inventors: Antonietta R. Mastrocola, Robert L. Webb
  • Process for preparing new imidazolemethylphosphonium salts
    Patent number: 4163858
    Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: August 7, 1979
    Assignee: SK&F Lab Co.
    Inventors: Clifford S. Labaw, Robert L. Webb, George R. Wellman
  • Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
    Patent number: 4139708
    Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: February 13, 1979
    Assignee: SK&F Lab Co.
    Inventors: Clifford S. Labaw, Robert L. Webb, George R. Wellman
  • Process for preparing 4-substituted imidazole compounds
    Patent number: 4119781
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: October 10, 1978
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Brushless direct current motor
    Patent number: 4025831
    Abstract: A direct current motor is provided by a rotor provided with a plurality of permanent magnets, at least one fixed electromagnet slightly spaced from the rotor periphery and a magnetically operated reversing switch controlled by the permanent rotor magnets to excite an electromagnet to alternately attract and repel the permanent magnets. The switch may be controlled by magnets other than the rotor magnets, rotated synchronously with the rotor.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: May 24, 1977
    Inventor: Robert L. Webb