Patents by Inventor Robert L. White

Robert L. White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180128822
    Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.
    Type: Application
    Filed: December 4, 2017
    Publication date: May 10, 2018
    Inventors: Shan Xiang Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
  • Patent number: 9863939
    Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 9, 2018
    Assignees: MagArray, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shan X. Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
  • Patent number: 8318093
    Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: November 27, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
  • Publication number: 20120122732
    Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
    Type: Application
    Filed: May 17, 2007
    Publication date: May 17, 2012
    Inventors: Shan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
  • Patent number: 7984638
    Abstract: A gas chromatograph oven including a housing, a capillary tube and a thermal control assembly. The housing defining a capillary tube receiving space and having at least one outlet port to permit the passage of a fluid from the capillary tube receiving space of the housing. The capillary tube is positioned in the capillary tube receiving space of the housing and has a gas inlet end connectable to a gas injector and a gas detector end connectable to a gas detector. The thermal control assembly is in fluid communication with the capillary tube receiving space of the housing and is connectable to a source of a temperature regulating fluid.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: July 26, 2011
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Robert L. White
  • Patent number: 7906345
    Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: March 15, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shan X Wang, Robert L White, Chris D Webb, Guanxiong Li
  • Patent number: 7682838
    Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: March 23, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
  • Patent number: 7682837
    Abstract: The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: March 23, 2010
    Assignee: Board of Trustees of Leland Stanford Junior University
    Inventors: Maneesh Jain, Robert L. White, Lester A. Roberts
  • Publication number: 20100000291
    Abstract: A gas chromatograph oven including a housing, a capillary tube and a thermal control assembly. The housing defining a capillary tube receiving space and having at least one outlet port to permit the passage of a fluid from the capillary tube receiving space of the housing. The capillary tube is positioned in the capillary tube receiving space of the housing and has a gas inlet end connectable to a gas injector and a gas detector end connectable to a gas detector. The thermal control assembly is in fluid communication with the capillary tube receiving space of the housing and is connectable to a source of a temperature regulating fluid.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 7, 2010
    Inventor: Robert L. White
  • Patent number: 7642830
    Abstract: A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock signal and the data synchronization signal and produces a delay control signal. A first delay circuit produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 5, 2010
    Assignee: Texas Instruments Incorporated
    Inventor: Robert L White
  • Patent number: 7615382
    Abstract: The present invention provides a magnetic sifter that is small in scale, enables three-dimensional flow in a direction normal to the substrate, allows relatively higher capture rates and higher flow rates, and provides a relatively easy method of releasing captured biomolecules. The magnetic sifter includes at least one substrate. Each substrate contains a plurality of slits, each of which extends through the substrate. The sifter also includes a plurality of magnets attached to the bottom surface of the substrate. These magnets are located proximal to the openings of the slits. An electromagnetic source controls the magnitude and direction of magnetic field gradient generated by the magnets. Either one device may be used, or multiple devices may be used in series. In addition, the magnetic sifter may be used in connection with a detection chamber.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: November 10, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shan X. Wang, Nader Pourmand, Robert L. White
  • Publication number: 20090104707
    Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 23, 2009
    Inventors: Shan X. Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
  • Publication number: 20090051398
    Abstract: A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock signal and the data synchronization signal and produces a delay control signal. A first delay circuit produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
    Type: Application
    Filed: October 30, 2008
    Publication date: February 26, 2009
    Applicant: TEXAS INSTRUMENTS INCORPORATED
    Inventor: Robert L. White
  • Patent number: 7463075
    Abstract: A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock signal and the data synchronization signal and produces a delay control signal. A first delay circuit produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: December 9, 2008
    Assignee: Texas Instruments Incorporated
    Inventor: Robert L. White
  • Publication number: 20080255006
    Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
    Type: Application
    Filed: November 9, 2007
    Publication date: October 16, 2008
    Inventors: Shan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
  • Publication number: 20070296477
    Abstract: A delay locked loop includes a storage element coupled to a data bus and produces a data synchronization signal. A phase detector receives a data clock signal and the data synchronization signal and produces a delay control signal. A first delay circuit produces a signal which is delayed relative to the data clock signal according to the delay control signal. A second delay circuit receiving the delayed signal produces a control signal coupled to a control input of the storage element by delaying the delayed signal an amount which causes the control signal to have a predetermined duty cycle.
    Type: Application
    Filed: June 23, 2006
    Publication date: December 27, 2007
    Inventor: Robert L. White
  • Patent number: 6885007
    Abstract: A radiation detection system has a linear array of radiation detectors, which are preferably ionization chambers. The detectors are connected, preferably permanently, to a multi-channel signal processor through a flexible multi-conductor shielded cable. The multi-channel signal processor is connected to a controller, such as a personal computer, through a multi-conductor cable and a communication interface device. Multiple detector arrays and multi-channel electrometers may be connected to a single personal computer and used simultaneously.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: April 26, 2005
    Assignee: Cardinal Health 419, L.L.C.
    Inventors: David M. Donaghue, Robert L. White, Leonard W. Zimmermann
  • Publication number: 20020081714
    Abstract: The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.
    Type: Application
    Filed: August 7, 2001
    Publication date: June 27, 2002
    Inventors: Maneesh Jain, Robert L. White, Lester A. Roberts
  • Patent number: 6073648
    Abstract: A laminated coating protects a metal substrate in a highly corrosive and highly erosive environment. A coating of a noble metal, such as gold, is bonded to the metal substrate, such as by electroplating or by flame spray. The noble-metal coating protects the metal substrate from the corrosive effects of a process fluid. A ceramic material, such as chromium oxide or titanium dioxide, is bonded to the noble-metal coating. Ceramic materials resist abrasion very well, which protects the underlying noble-metal coating from the erosive/abrasive effects of the process solution, which may contain suspended solids that are highly abrasive. However, the ceramic material is somewhat porous, which allows some seepage of the process fluid. The metal substrate is protected from the corrosive effects of the process fluid by the noble-metal coating.
    Type: Grant
    Filed: April 26, 1999
    Date of Patent: June 13, 2000
    Assignee: Watson Grinding and Manufacturing Company
    Inventors: James L. Watson, John M. Watson, Robert L. White, William P. Ferree
  • Patent number: 5587223
    Abstract: Magnetic recording media comprising an ordered, ultra-high density array of 500 .ANG. diameter circular magnetic thin film islands on a substrate. The magnetic material supports magnetization perpendicular to the film plan, and each circular island comprises a single magnetic domain and a single information storage bit. An areal bit density of 10.sup.11 bits/in.sup.2 can be achieved by such an array. The magnetic array is generated using a single level mask comprised of a self-ordering polymer array, either an array of polymer spheres or a regular array of polymeric blocks in a phase-separating polymer film.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: December 24, 1996
    Assignee: Board of Trustees Leland Stanford, Jr. University
    Inventor: Robert L. White