Patents by Inventor Robert LAFYATIS

Robert LAFYATIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of aortic carboxypeptidase-like protein (ACLP)
    Patent number: 12139542
    Abstract: The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compostions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGF? receptor superfamily.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: November 12, 2024
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Matthew D. Layne, Kathleen E. Tumelty, Robert Lafyatis
  • INHIBITORS OF FIBROPROLIFERATIVE DISORDERS AND CANCER
    Publication number: 20170190778
    Abstract: The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGF? receptor superfamily.
    Type: Application
    Filed: May 27, 2015
    Publication date: July 6, 2017
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Matthew D. LAYNE, Kathleen E. TUMELTY, Robert LAFYATIS