Abstract: Methods and devices for controlling motorized surgical devices are provided. In general, the methods and devices can allow a surgical device to grasp and cut tissue. In some embodiments, the device's motor can begin providing power for grasping and/or cutting tissue in response to an output from the device's sensor, the device can adjust power provided by the motor based on whether the device is clamping tissue or is being fired, the device can adjust an amount of power provided by the motor based on an amount of user-applied force to the device's actuator and/or can control drive direction of the motor based on the amount of the force, the device can maintain a force applied to the device, the device can self-shift the motor, and/or the device can adjust an amount of power provided to the device's end effector based on a degree of the end effector's closure.

Abstract: A managed container may be configured to manage enterprise applications, manage enterprise information stored on a device, manage a protected storage area used by the managed container to store and reference the enterprise applications during execution, and manage a database storing enterprise rules related to management of the enterprise applications and the enterprise information. The managed container may communicate with an application gateway server to control download and update of the enterprise applications, the enterprise information, and the enterprise rules. The application gateway server may be coupled to a backend enterprise application. At least one of the enterprise applications may be configured to execute in conjunction with the backend enterprise application according to at least one of the enterprise rules, and is configured to, according to another one of the enterprise rules, manage the enterprise information associated with the backend enterprise application.

Abstract: A hosted application gateway server node may be communicatively coupled to backend systems, client devices, and database shards associated with database servers. Through the gateway server node, various services may be provided to managed containers running on client devices such that enterprise applications can be centrally managed. A sharding manager may manage relationships of database items across database shards. Each shard stores a copy of a table representing a split of a relationship. A shard ID mask is included in each item's ID. At query time, the shard ID can be extracted and used to query the correct database. This query routing mechanism allows navigation from one shard to another when multiple items are in a relationship (e.g., share the same resource such as a document). As such, embodiments can eliminate the need for APIs to join in data that span multiple shards.

Abstract: A managed container may have a managed cache storing content managed by or through an application gateway server computer. The managed container may receive a request for content from an application running in a secure shell provided by the managed container on a client device. The managed container may determine whether the client device is within a specified geographical location. If not, the managed container may deny or restrict the application access to the requested content. The access denial or restriction may continue until a connection is made to the application gateway server computer or until the client device has returned to within the specified geographical location. If the client device is within the specified geographical location, the managed container may provide or restore access to requested content. Embodiments of the managed container can therefore perform geofencing by disabling or limiting access to content based on predetermined secure/insecure designations.

Abstract: A remote wipe message or notification may be sent from a server computer to one or more target client devices associated with a user. A managed container running on a target client device associated with the user and having a managed cache storing content managed by or through the server computer may, in response to the remote wipe message or notification, deleting the managed content or a portion thereof from its managed cache. The managed container may send back an acknowledgement or message to the server computer that it had completed the remote wipe. The remote wipe functionality can avoid having to deal with individual applications running on the client device and therefore can eliminate the complexity of having to deal with individual applications. Furthermore, the remote wipe can be done independently of the local operating system and without affecting non-managed information/applications on the client device.

Abstract: Embodiments of an application gateway architecture may include an application gateway server computer communicatively connected to backend systems and client devices operating on different platforms. The application gateway server computer may include application programming interfaces and services configured for communicating with the backend systems and managed containers operating on the client devices. The application gateway server computer may provide applications that can be centrally managed and may extend the capabilities of the client devices, including the ability to authenticate across backend systems. A managed container may include a managed cache and may provide a secure shell for applications received from the application gateway server computer. The managed container may store the applications in the managed cache and control access to the managed cache according to rules propagated from at least one of the backend systems via the application gateway server computer.

Abstract: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.

Abstract: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.

Abstract: A method of authenticating a polymer film comprises measuring the thickness of a layer therein by white light interferometry and/or measuring the birefringence of a layer therein. The method, and devices to carry out the method, may be used in security applications, for example to test for counterfeit bank notes.

Abstract: There is described a method of tracking an article (30) and protecting it against tampering and counterfeiting, the method comprising the steps of providing an article; providing a film (1c) for wrapping or labelling the article; marking the film with a code (5c); defining an area of interest (35) on the article or the film; wrapping or labelling the article with the film so that the code at least partially overlays the area of interest to define a tracking zone in the region of the at least partial overlay; imaging the tracking zone of the wrapped or labelled article; and storing the imaged date for identifying the article. There is also described, use of a frequency-tripled neodymium-doped yttrium aluminium garnet (nd:YAG) laser in marking a code (5c) on a film (1c), the code comprising an at least partly random pattern of perforations (21, 23, 25).

Abstract: The present invention provides a security document and method of production thereof. The security document (10) comprises: a polymer substrate (12) having first (14) and second (22) surfaces; a security feature (16) formed in a region of at least one of said first and second surfaces of said polymer substrate; an opacifying layer (18, 24) formed on at least a portion of at least one of said first and second surfaces of said polymer substrate; a printed design formed on at least a portion of said opacifying layer; and wherein said security feature is formed at least prior to said printed design being formed.

Abstract: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.

Abstract: A neck-mounted personal eating apparatus designed to facilitate eating by a person away from a table, is herein disclosed. The apparatus comprises a rectangular tray equipped with a raised lip around the entire perimeter to prevent liquid spills or loss of crumbs. The short side edges of the tray are provided with an adjustable padded neck strap which goes up and around the rear neck area of the user and attaches to the opposite sides of the tray. The neck strap comprises a flexible plastic “U”-shape strap having a plurality of holes to allow for adjustment. The holes connect to molded ball-end appendages located on either side of the tray. In such a manner, the neck strap can be easily resized to suit all size users from large adults to small children. Additionally, the apparatus comprises an angled fixed length strap that connects to the neck strap to help keep the tray level and prevent movement during use.

Abstract: A method of authenticating a polymer film comprises measuring the thickness of a layer therein by white light interferometry and/or measuring the birefringence of a layer therein. The method, and devices to carry out the method, may be used in security applications, for example to test for counterfeit bank notes.

Abstract: A method of and apparatus for assembling an aircraft wheel or brake (10) component on an axle (26) of an undercarriage in which a holder (12) is provided for the component along with a lifting device (28). The lifting device is used to lift the holder with the component therein to a position where the component is substantially in axial alignment with the axle. Once in that position, assembly of the component on the axle can take place by moving the component axially on to the axle. The holder can then be lowered away from the assembled component.

Abstract: A tissue-separating catheter assembly comprises a rotatable shaft, having a distal shaft portion, and a tissue separator device extending along the shaft. The tissue separator device has a distal separator part at the distal shaft portion movable between a retracted state, towards the distal shaft portion, and an outwardly extending, operational state, away from the distal shaft portion. A localization device is movable to a radially expanded state. An expandable tubular element is movable so that its outer end is generally axially aligned with the localization device so to capture a separated tissue section therebetween to aid removal of the separated tissue section from the patient.

Abstract: A tissue separator assembly has an elongate tubular member and a tissue separator device located at a distal end of the elongate tubular member. An elongate coupler extends through the lumen of the elongate tubular member and has a distal coupler end. A tissue localization assembly has an elongate member and a localization device located at the distal end of the elongate member. The localization device may be movable from a first, radially-contracted state to a second, radially-expandable state. The distal coupler end of the elongate coupler and the proximal end of the elongate tubular member of the localization assembly are joinable to one another to permit docking of the tissue localization assembly to the tissue separator assembly. Methods of use of this device are also described.

Abstract: The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent-heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia.

Abstract: A method of and apparatus for assembling an aircraft wheel or brake (10) component on an axle (26) of an undercarriage in which a holder (12) is provided for the component along with a lifting device (28). The lifting device is used to lift the holder with the component therein to a position where the component is substantially in axial alignment with the axle. Once in that position, assembly of the component on the axle can take place by moving the component axially on to the axle. The holder can then be lowered away from the assembled component.

Abstract: The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia.